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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Aug 2015.

Carnitine palmitoyltransferase 1A

CPT I, CPT1, carnitine palmitoyltransferase-1
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, PPAR, HAD, AMPK
Papers using CPT I antibodies
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Supplier
Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... USA), ABCG2 by Cell Signaling Technology (Boston, MA, USA), OCTN2 by Abcam (Cambridge, MA, USA), CPT1 by Bioss Biotech (Beijing, P ...
Papers on CPT I
Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate.
New
Muller et al., Portugal. In Mol Nutr Food Res, 27 Sep 2015
Peroxisome proliferator-activated receptor alpha and gamma (PPARα and γ), and carnitine palmitoyltransferase one (CPT1) expression were increased by ASP alone.
Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes.
New
Zheng et al., Nanjing, China. In Iubmb Life, 25 Sep 2015
Moreover, curcumin alleviated the symptom of hyperlipidemia and hepatic steatosis via modulating the expression of sterol regulatory element-binding protein-1c, fatty acid synthase, and peroxisome proliferator-activated receptor-alpha as well as the activity of carnitine palmitoyltransferase 1.
Effects of water management practices on residue decomposition and degradation of Cry1Ac protein from crop-wild Bt rice hybrids and parental lines during winter fallow season.
New
Song et al., Shanghai, China. In Ecotoxicol Environ Saf, 18 Sep 2015
We used litter bags to assess the residue (leaves, stems and roots) decomposition dynamics of two transgenic rice lines (Kefeng6 and Kefeng8) containing stacked genes from Bt and sck (a modified CpTI gene encoding a cowpea trypsin inhibitor) (Bt/CpTI), a non-transgenic rice near-isoline (Minghui86), wild rice (Oryza rufipogon) and crop-wild Bt rice hybrid under contrasting conditions (drainage or continuous flooding) in the field.
Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis.
New
Andrews et al., Australia. In Mol Cell Endocrinol, 07 Sep 2015
In terms of nutrient regulation, carnitine metabolism regulates hypothalamic fatty acid sensing through the actions of CPT1 and has an underappreciated role in glucose sensing since carnitine metabolism also buffers mitochondrial matrix levels of acetyl-CoA, an allosteric inhibitor of pyruvate dehydrogenase and hence glucose metabolism.
Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
New
Impact
Carmeliet et al., Leuven, Belgium. In Nature, May 2015
Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells.
FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes.
New
Sun et al., China. In Sci Rep, Dec 2014
In this study, we found that FABP4 reduced the expression of leptin, CPT-1 and AOX1 in mice adipocytes.
Potential role of oxidative protein modification in energy metabolism in exercise.
Review
Yoshikawa et al., Kyoto, Japan. In Subcell Biochem, 2013
We detected the modification of carnitine palmitoyltransferase I (CPT I) by Nε-(hexanoyl)lysine (HEL), one of the lipid peroxides, in exercised muscles, while the antioxidant astaxanthin reduced this oxidative stress-induced modification.
Hypothalamic malonyl-CoA and the control of food intake.
Review
Butler et al., Jupiter, United States. In Physiol Behav, 2013
Malonyl-CoA inhibits the acyltransferase activity of carnitine palmitoyltransferase-1 (CPT-1), and CPT-1 was considered as a downstream effector in hypothalamic malonyl-CoA effect on feeding.
The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain.
Review
Huang et al., Wollongong, Australia. In Cns Drugs, 2013
During short-term treatment, hypothalamic H1 receptor antagonism by SGAs may activate the AMPK-carnitine palmitoyltransferase 1 signaling to rapidly increase caloric intake and result in weight gain.
Companion Animals Symposium: nutrigenomics: using gene expression and molecular biology data to understand pet obesity.
Review
Swanson et al., Urbana, United States. In J Anim Sci, 2013
Diets including prebiotics, green tea extract, or increased concentrations of protein have been shown to modify the expression of several genes related to glucose and lipid metabolism in adipose [e.g., uncoupling protein-2, carnitine palmitoyltransferase-1, PPARα, lipoprotein lipase (LPL), and glucose transporter 4] and skeletal muscle (e.g., PPARα and LPL) tissues.
Molecular mechanisms of hypolipidemic effects of curcumin.
Review
Meydani et al., Boston, United States. In Biofactors, 2013
At the molecular level, mounting experimental evidence suggests that curcumin may act chemically as scavenger of free radicals and/or influences signal transduction (e.g., Akt, AMPK) and modulates the activity of specific transcription factors (e.g., FOXO1/3a, NRF2, SREBP1/2, CREB, CREBH, PPARγ, and LXRα) that regulate the expression of genes involved in free radicals scavenging (e.g., catalase, MnSOD, and heme oxygenase-1) and lipid homeostasis (e.g., aP2/FABP4, CD36, HMG-CoA reductase, and carnitine palmitoyltransferase-I (CPT-1)).
Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.
GeneRIF
Casals et al., Sant Cugat del Vallès, Spain. In J Biol Chem, 2012
CPT1C regulates the levels of ceramide in the endoplasmic reticulum of hippocampal neurons
Blood cells as a source of transcriptional biomarkers of childhood obesity and its related metabolic alterations: results of the IDEFICS study.
GeneRIF
IDEFICS Consortium et al., Palma, Spain. In J Clin Endocrinol Metab, 2012
Data suggest that CPT1A, leptin receptor (LEPR), and insulin receptor (INSR) mRNA levels are higher in blood cells/blood from overweight children compared with normal weight children; INSR and CPT1A are increased only in males.
TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
GeneRIF
Mignot et al., Beijing, China. In Sleep Med, 2012
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population.
Exertional rhabdomyolysis: a clinical review with a focus on genetic influences.
GeneRIF
Campbell et al., Bethesda, United States. In J Clin Neuromuscul Dis, 2012
Genetic mutations causative for McArdle disease, carnitine palmitoyl transferase deficiency 2, myoadenylate deaminase deficiency, and malignant hyperthermia have all been associated with Exertional rhabdomyolysis.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
GeneRIF
Hagen et al., Corvallis, United States. In Mech Ageing Dev, 2012
-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart
Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.
Review
Impact
Jaswal et al., Edmonton, Canada. In Pharmacol Rev, 2010
Malonyl CoA inhibits carnitine palmitoyltransferase-1 (CPT-1), and it has been proposed that the substrate of CPT-1, long-chain acyl CoA(s), may act as a mediator(s) of appetite and energy balance.
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Impact
Diano et al., New York City, United States. In Nature, 2008
The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2.
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Impact
Vidal-Puig et al., A Coruña, Spain. In Cell Metab, 2008
Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis induced by AMP-activated protein kinase (AMPK) resulting in decreased hypothalamic levels of malonyl-CoA and increased carnitine palmitoyltransferase 1 (CPT1) activity.
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Impact
Kunos et al., Bethesda, United States. In Cell Metab, 2008
Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment.
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