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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Jul 2015.

Carnitine palmitoyltransferase 1A

CPT I, CPT1, carnitine palmitoyltransferase-1
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, PPAR, HAD, AMPK
Papers using CPT I antibodies
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Supplier
Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... USA), ABCG2 by Cell Signaling Technology (Boston, MA, USA), OCTN2 by Abcam (Cambridge, MA, USA), CPT1 by Bioss Biotech (Beijing, P ...
Papers on CPT I
Amelioration of Free Fatty Acid-Induced Fatty Liver by Quercetin-3-O-β-D-Glucuronide Through Modulation of PPARα/SREBP-1c Signaling.
New
Shang et al., China. In Hepatol Res, 17 Aug 2015
Besides, Q3GA decreased the expression of sterol regulatory element binding transcription factor protein-1c (SREBP-1c), fatty acid synthase (FAS) and increased the expression of peroxisome proliferator activated receptor alpha (PPARα), carnitine palmitoyl-transferase 1 (CPT1), and medium-chain acyl-CoA dehydrogenase (MCAD) in vivo and in vitro.
Fermented Rhus verniciflua STOKES extract (FRVE) exerts an anti-hepatic lipogenenic effect in oleic acid induced HepG2 cells via up-regulation of AMP-activaed protein kinase (AMPK).
New
Lee et al., In J Agric Food Chem, 15 Aug 2015
Moreover, FRVE activated low-density lipoproteins receptor (LDLR), AMPK ,as well as, fatty acid oxidation related factors, peroxisome proliferator activated receptor α (PPARα) and carnitine palmitoyltransferase 1 (CPT-1).
Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes expression.
New
de Lima et al., São Paulo, Brazil. In Biochim Biophys Acta, 11 Aug 2015
On the other hand, TLR4 deficiency enhanced the expression of several enzymes involved in the oxidation of fatty acids, as follows: ACOX, CPT-1, MTPa, MTBb, PBE and 3-ketoacyl-CoA thiolase.
Effects of waterborne copper exposure on carnitine composition, kinetics of carnitine palmitoyltransferases I (CPT I) and mRNA levels of CPT I isoforms in yellow catfish Pelteobagrus fulvidraco.
New
Zhuo et al., Wuhan, China. In Chemosphere, 11 Aug 2015
UNASSIGNED: The present study was conducted to determine the effect of waterborne copper (Cu) exposure on carnitine concentration, carnitine palmitoyltransferases I (CPT I) kinetics, and expression levels of four CPT I isoforms in the liver, muscle and heart of yellow catfish Pelteobagrus fulvidraco.
Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
New
Impact
Carmeliet et al., Leuven, Belgium. In Nature, May 2015
Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells.
Rats Prone to Obesity Under a High-Carbohydrate Diet have Increased Post-Meal CCK mRNA Expression and Characteristics of Rats Fed a High-Glycemic Index Diet.
New
Even et al., Paris, France. In Front Nutr, Dec 2014
ITT, GTT, and MTT showed that CS rats were neither insulin resistant nor glucose intolerant, but mRNA expression of cholecystokinin (CCK) in the duodenum was higher and that of CPT1, PPARα, and PGC1α in liver were lower than in CR rats.
Potential role of oxidative protein modification in energy metabolism in exercise.
Review
Yoshikawa et al., Kyoto, Japan. In Subcell Biochem, 2013
We detected the modification of carnitine palmitoyltransferase I (CPT I) by Nε-(hexanoyl)lysine (HEL), one of the lipid peroxides, in exercised muscles, while the antioxidant astaxanthin reduced this oxidative stress-induced modification.
Hypothalamic malonyl-CoA and the control of food intake.
Review
Butler et al., Jupiter, United States. In Physiol Behav, 2013
Malonyl-CoA inhibits the acyltransferase activity of carnitine palmitoyltransferase-1 (CPT-1), and CPT-1 was considered as a downstream effector in hypothalamic malonyl-CoA effect on feeding.
The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain.
Review
Huang et al., Wollongong, Australia. In Cns Drugs, 2013
During short-term treatment, hypothalamic H1 receptor antagonism by SGAs may activate the AMPK-carnitine palmitoyltransferase 1 signaling to rapidly increase caloric intake and result in weight gain.
Companion Animals Symposium: nutrigenomics: using gene expression and molecular biology data to understand pet obesity.
Review
Swanson et al., Urbana, United States. In J Anim Sci, 2013
Diets including prebiotics, green tea extract, or increased concentrations of protein have been shown to modify the expression of several genes related to glucose and lipid metabolism in adipose [e.g., uncoupling protein-2, carnitine palmitoyltransferase-1, PPARα, lipoprotein lipase (LPL), and glucose transporter 4] and skeletal muscle (e.g., PPARα and LPL) tissues.
Molecular mechanisms of hypolipidemic effects of curcumin.
Review
Meydani et al., Boston, United States. In Biofactors, 2013
At the molecular level, mounting experimental evidence suggests that curcumin may act chemically as scavenger of free radicals and/or influences signal transduction (e.g., Akt, AMPK) and modulates the activity of specific transcription factors (e.g., FOXO1/3a, NRF2, SREBP1/2, CREB, CREBH, PPARγ, and LXRα) that regulate the expression of genes involved in free radicals scavenging (e.g., catalase, MnSOD, and heme oxygenase-1) and lipid homeostasis (e.g., aP2/FABP4, CD36, HMG-CoA reductase, and carnitine palmitoyltransferase-I (CPT-1)).
Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.
GeneRIF
Casals et al., Sant Cugat del Vallès, Spain. In J Biol Chem, 2012
CPT1C regulates the levels of ceramide in the endoplasmic reticulum of hippocampal neurons
Blood cells as a source of transcriptional biomarkers of childhood obesity and its related metabolic alterations: results of the IDEFICS study.
GeneRIF
IDEFICS Consortium et al., Palma, Spain. In J Clin Endocrinol Metab, 2012
Data suggest that CPT1A, leptin receptor (LEPR), and insulin receptor (INSR) mRNA levels are higher in blood cells/blood from overweight children compared with normal weight children; INSR and CPT1A are increased only in males.
TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
GeneRIF
Mignot et al., Beijing, China. In Sleep Med, 2012
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population.
Exertional rhabdomyolysis: a clinical review with a focus on genetic influences.
GeneRIF
Campbell et al., Bethesda, United States. In J Clin Neuromuscul Dis, 2012
Genetic mutations causative for McArdle disease, carnitine palmitoyl transferase deficiency 2, myoadenylate deaminase deficiency, and malignant hyperthermia have all been associated with Exertional rhabdomyolysis.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
GeneRIF
Hagen et al., Corvallis, United States. In Mech Ageing Dev, 2012
-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart
Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.
Review
Impact
Jaswal et al., Edmonton, Canada. In Pharmacol Rev, 2010
Malonyl CoA inhibits carnitine palmitoyltransferase-1 (CPT-1), and it has been proposed that the substrate of CPT-1, long-chain acyl CoA(s), may act as a mediator(s) of appetite and energy balance.
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Impact
Diano et al., New York City, United States. In Nature, 2008
The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2.
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Impact
Vidal-Puig et al., A Coruña, Spain. In Cell Metab, 2008
Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis induced by AMP-activated protein kinase (AMPK) resulting in decreased hypothalamic levels of malonyl-CoA and increased carnitine palmitoyltransferase 1 (CPT1) activity.
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Impact
Kunos et al., Bethesda, United States. In Cell Metab, 2008
Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment.
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