GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Carnitine palmitoyltransferase 1A
CPT I, CPT1, carnitine palmitoyltransferase-1
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
CPT I
antibodies
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... USA), ABCG2 by Cell Signaling Technology (Boston, MA, USA), OCTN2 by Abcam (Cambridge, MA, USA), CPT1 by Bioss Biotech (Beijing, P ...
Papers on
CPT I
Dietary L-arginine supplementation reduces abdominal fat content by modulating lipid metabolism in broiler chickens.
New
China. In Animal, 11 Apr 2013
However, chickens supplemented with L-Arg had lower abdominal fat content, plasma triglyceride (TG), total cholesterol (TC) concentrations, hepatic FAS mRNA expression and increased heart carnitine palmitoyl transferase1 (CPT1) and 3-hydroxyacyl-CoA dehydrogenase (3HADH) mRNA expression.
Endothelial Lipase Modulates Pressure Overload-Induced Heart Failure Through Alternative Pathway for Fatty Acid Uptake.
New
Kōbe, Japan. In Hypertension, 04 Apr 2013
The expression of mitochondrial fatty acid oxidation-related genes, such as carnitine palmitoyltransferase-1 and medium-chain acyl coenzyme A dehydrogenase, was significantly lower in the heart of endothelial lipase-/- mice than in wild-type mice.
Erratum to: 4 INFLUENCE OF A MATERNAL DIABETES MELLITUS TYPE 1 ON LIPID AND CHOLESTEROL METABOLISM IN RABBIT PRE-IMPLANTATION EMBRYOS.
New
In Reprod Fertil Dev, 31 Mar 2013
The expression of genes important for lipid metabolism, such as fatty acid transport protein 4 (FATP4), fatty acid-binding protein 4 (FABP4), carnitine palmitoyltransferase 1 (CPT-1), and lipoprotein lipase (LPL), were determined by real-time PCR and showed distinct differences between diabetic and control blastocysts.
Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats.
New
Cincinnati, United States. In J Lipid Res, 22 Mar 2013
Using primary cultured rat hepatic cells, we found that the rate of fatty acid oxidation and the activity of carnitine palmitoyltransferase-1 (CPT1), a key enzyme in fatty acid beta-oxidation, were significantly elevated in Rb1-treated hepatocytes compared to those of vehicle-treated cells.
Promoting lipid utilization with l-carnitine to improve oocyte quality.
Review
New
Adelaide, Australia. In Anim Reprod Sci, Sep 2012
Transport of activated fatty acids into mitochondria is catalyzed by carnitine palmitoyl transferase-I (CPTI) which also requires the metabolite carnitine.
MicroRNAs regulating lipid metabolism in atherogenesis.
Review
New
New York City, United States. In Thromb Haemost, Apr 2012
By repressing a variety of genes involved in cholesterol export and fatty acid oxidation, including ABCA1, CROT, CPT1, HADHB and PRKAA1, miR-33a/b act in concert with their host genes to boost cellular sterol levels.
A Novel Mutation in CPT1A Resulting in Hepatic CPT Deficiency.
Lille, France. In Jimd Rep, 2011
In early childhood, the patient developed a life-threatening episode (hypoketotic hypoglycemia, liver cytolysis, and hepatomegaly) evocative of a mitochondrial fatty acid oxidation disorder, and presented deficient fibroblast carnitine palmitoyltransferase 1 (CPT1) activity and homozygosity for the c.1783 C > T nucleotide substitution on exon 15 of CPT1A (p.R595W mutant).
Central mechanisms involved in the orexigenic actions of ghrelin.
Review
Australia. In Peptides, 2011
The downstream signaling involves a novel CaMKK-AMPK-CPT1-UCP2 pathway that enhances mitochondrial efficiency and buffers reactive oxygen species in order to maintain an appropriate firing response in NPY.
Ghrelin-mediated appetite regulation in the central nervous system.
Review
Kraków, Poland. In Peptides, 2011
However, it plays a key role in the metabolic changes of lipids, mainly those involving hypothalamic NOS, AMPK, CaMKK2, CPT1 and UCP2 proteins.
Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly.
GeneRIF
Baltimore, United States. In J Neurochem, 2011
CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet
Prospects for using proteinase inhibitors to protect transgenic plants against attack by herbivorous insects.
Review
Durham, United Kingdom. In Curr Protein Pept Sci, 2011
In Chinese genetically engineered cotton varieties which express Bt toxins as an insecticidal protein against lepidopteran larvae, the CpTI (cowpea trypsin inhibitor) gene has been employed as a second transgene to improve protection.
Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex.
GeneRIF
Cleveland, United States. In J Biol Chem, 2011
strong protein-protein interaction between CPT1a, long chain acyl-CoA synthetase, and voltage-dependent anion channel
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.
GeneRIF
Edmonton, Canada. In Proc Natl Acad Sci U S A, 2011
Data show that the anorectic actions of central leptin or cerulenin are impaired in mice with brain CPT-1c deleted.
[Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].
GeneRIF
Shijiazhuang, China. In Zhonghua Yi Xue Za Zhi, 2011
The protein expressions of CPT-I and PPARdelta decreased in excessive fatigue rats.
Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet.
GeneRIF
Foggia, Italy. In Plos One, 2010
The goal of the present study was to achieve more understanding on the modification/s of carnitinepalmitoyltransferase-I (CPT-I), the rate-limiting enzyme of the mitochondrial fatty acid beta-oxidation, during steatohepatitis.
Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.
Review
Impact
Edmonton, Canada. In Pharmacol Rev, 2010
Malonyl CoA inhibits carnitine palmitoyltransferase-1 (CPT-1), and it has been proposed that the substrate of CPT-1, long-chain acyl CoA(s), may act as a mediator(s) of appetite and energy balance.
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Impact
New York City, United States. In Nature, 2008
The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2.
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Impact
A Coruña, Spain. In Cell Metab, 2008
Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis induced by AMP-activated protein kinase (AMPK) resulting in decreased hypothalamic levels of malonyl-CoA and increased carnitine palmitoyltransferase 1 (CPT1) activity.
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Impact
Bethesda, United States. In Cell Metab, 2008
Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment.
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Impact
Durham, United States. In Cell Metab, 2008
These results were recapitulated in mice lacking malonyl-CoA decarboxylase (MCD), an enzyme that promotes mitochondrial beta-oxidation by relieving malonyl-CoA-mediated inhibition of carnitine palmitoyltransferase 1.
