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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Carnitine palmitoyltransferase 1A

CPT I, CPT1, carnitine palmitoyltransferase-1
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, PPAR, HAD, CAN
Papers using CPT I antibodies
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Supplier
Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... USA), ABCG2 by Cell Signaling Technology (Boston, MA, USA), OCTN2 by Abcam (Cambridge, MA, USA), CPT1 by Bioss Biotech (Beijing, P ...
Papers on CPT I
Improved diagnosis of idiopathic giant cell myocarditis and cardiac sarcoidosis by myocardial gene expression profiling.
New
Schultheiss et al., Berlin, Germany. In Eur Heart J, 21 Sep 2014
The expression levels of genes coding for cytokines or chemokines (CCL20, IFNB1, IL6, IL17D; P < 0.05), cellular receptors (ADIPOR2, CCR5, CCR6, TLR4, TLR8; P < 0.05), and proteins involved in the mitochondrial energy metabolism (CPT1, CYB, DHODH; P < 0.05) were deregulated in 2- to 300-fold, respectively.
Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring.
New
Torsoni et al., Limeira, Brazil. In Br J Nutr, Jul 2014
Interestingly, mRNA expression levels of the β-oxidation-related genes ACADVL and CPT1 were decreased in HFD-O mice (P< 0·05).
Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats.
New
Takayanagi et al., Fukuoka, Japan. In World J Gastroenterol, Apr 2014
In adipose tissue, exenatide significantly upregulated lipolytic genes, including hormone-sensitive lipase, carnitine palmitoyltransferase-1, long-chain acyl-CoA dehydrogenase, and acyl-CoA oxidase 1 [HFD-Ex(-) vs HFD-Ex(+)].
Foetal life protein provision of mink (Neovison vison) changes the relative mRNA abundance of some hepatic enzymes regulating fat metabolism.
New
Tauson et al., Copenhagen, Denmark. In Arch Anim Nutr, Dec 2013
The relative abundances of acetyl coenzyme A carboxylase (ACC), fatty acid synthase (FAS) and carnitine palmitoyl transferase 1 (CPT1) mRNA were determined by qualitative polymerase chain reaction in the livers of F₀- and F₁-generation dams and in F₁-generation foetuses.
Hepatic β-oxidation and regulation of carnitine palmitoyltransferase (CPT) I in blunt snout bream Megalobrama amblycephala fed a high fat diet.
New
Liu et al., Nanjing, China. In Plos One, Dec 2013
Study of CPT I kinetics showed that CPT I had a low affinity for its substrates and a low catalytic efficiency in fish fed the high-fat diet.
Companion Animals Symposium: nutrigenomics: using gene expression and molecular biology data to understand pet obesity.
Review
New
Swanson et al., Urbana, United States. In J Anim Sci, Jun 2013
Diets including prebiotics, green tea extract, or increased concentrations of protein have been shown to modify the expression of several genes related to glucose and lipid metabolism in adipose [e.g., uncoupling protein-2, carnitine palmitoyltransferase-1, PPARα, lipoprotein lipase (LPL), and glucose transporter 4] and skeletal muscle (e.g., PPARα and LPL) tissues.
The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain.
Review
New
Huang et al., Wollongong, Australia. In Cns Drugs, Jun 2013
During short-term treatment, hypothalamic H1 receptor antagonism by SGAs may activate the AMPK-carnitine palmitoyltransferase 1 signaling to rapidly increase caloric intake and result in weight gain.
Targeting mitochondrial oxidative metabolism as an approach to treat heart failure.
Review
New
Lopaschuk et al., Edmonton, Canada. In Biochim Biophys Acta, Apr 2013
Carnitine palmitoyl transferase I (CPT1), fatty acid β-oxidation enzymes, and pyruvate dehydrogenase kinase (PDK) are examples of metabolic targets for the treatment of heart failure.
Molecular mechanisms of hypolipidemic effects of curcumin.
Review
Meydani et al., Boston, United States. In Biofactors, 2013
At the molecular level, mounting experimental evidence suggests that curcumin may act chemically as scavenger of free radicals and/or influences signal transduction (e.g., Akt, AMPK) and modulates the activity of specific transcription factors (e.g., FOXO1/3a, NRF2, SREBP1/2, CREB, CREBH, PPARγ, and LXRα) that regulate the expression of genes involved in free radicals scavenging (e.g., catalase, MnSOD, and heme oxygenase-1) and lipid homeostasis (e.g., aP2/FABP4, CD36, HMG-CoA reductase, and carnitine palmitoyltransferase-I (CPT-1)).
Targeting myocardial metabolism for the treatment of stable angina.
Review
Stefanadis et al., Athens, Greece. In Curr Pharm Des, 2012
Potential pharmacologic approaches should target i) the suppression of lipolysis and the plasma fatty acid levels and subsequent uptake and oxidation by the heart, ii) direct inhibition of the enzymes of fatty acid beta-oxidation, iii) inhibition of carnitine palmitoyl transferase- I (CPT-1).
Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.
GeneRIF
Casals et al., Sant Cugat del Vallès, Spain. In J Biol Chem, 2012
CPT1C regulates the levels of ceramide in the endoplasmic reticulum of hippocampal neurons
Blood cells as a source of transcriptional biomarkers of childhood obesity and its related metabolic alterations: results of the IDEFICS study.
GeneRIF
IDEFICS Consortium et al., Palma, Spain. In J Clin Endocrinol Metab, 2012
Data suggest that CPT1A, leptin receptor (LEPR), and insulin receptor (INSR) mRNA levels are higher in blood cells/blood from overweight children compared with normal weight children; INSR and CPT1A are increased only in males.
TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
GeneRIF
Mignot et al., Beijing, China. In Sleep Med, 2012
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population.
Exertional rhabdomyolysis: a clinical review with a focus on genetic influences.
GeneRIF
Campbell et al., Bethesda, United States. In J Clin Neuromuscul Dis, 2012
Genetic mutations causative for McArdle disease, carnitine palmitoyl transferase deficiency 2, myoadenylate deaminase deficiency, and malignant hyperthermia have all been associated with Exertional rhabdomyolysis.
Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart.
GeneRIF
Hagen et al., Corvallis, United States. In Mech Ageing Dev, 2012
-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart
Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.
Review
Impact
Jaswal et al., Edmonton, Canada. In Pharmacol Rev, 2010
Malonyl CoA inhibits carnitine palmitoyltransferase-1 (CPT-1), and it has been proposed that the substrate of CPT-1, long-chain acyl CoA(s), may act as a mediator(s) of appetite and energy balance.
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Impact
Diano et al., New York City, United States. In Nature, 2008
The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2.
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Impact
Vidal-Puig et al., A Coruña, Spain. In Cell Metab, 2008
Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis induced by AMP-activated protein kinase (AMPK) resulting in decreased hypothalamic levels of malonyl-CoA and increased carnitine palmitoyltransferase 1 (CPT1) activity.
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Impact
Kunos et al., Bethesda, United States. In Cell Metab, 2008
Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment.
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Impact
Muoio et al., Durham, United States. In Cell Metab, 2008
These results were recapitulated in mice lacking malonyl-CoA decarboxylase (MCD), an enzyme that promotes mitochondrial beta-oxidation by relieving malonyl-CoA-mediated inhibition of carnitine palmitoyltransferase 1.
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