GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 17 Jun 2013.
Carnitine palmitoyltransferase 1A
CPT I, CPT1, carnitine palmitoyltransferase-1
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
CPT I
antibodies
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... USA), ABCG2 by Cell Signaling Technology (Boston, MA, USA), OCTN2 by Abcam (Cambridge, MA, USA), CPT1 by Bioss Biotech (Beijing, P ...
Papers on
CPT I
Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.
New
In Am J Physiol Endocrinol Metab, 04 Jul 2013
Carnitine palmitoyltransferase-1 (CPT-1) liver isoform or CPT-1a is implicated in CNS control of food intake.
Mulberry anthocyanins inhibits oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance.
New
In J Agric Food Chem, 03 Jul 2013
In contrast, the lipolytic enzyme expression of peroxisome proliferator activated receptor α (PPARα) and carnitinepalmitol- transferase-1 (CPT1) were increased.
Genetic diagnosis of one family with incomplete clinical data.
New
In J Pediatr Endocrinol Metab, 24 Jun 2013
Direct sequencing of the exons and exon-intron boundaries of GAA, SLC25A5, CPT1, CPT2, SLC25A20 and MUT genes were performed on the parents of the patient.
Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway.
New
Baton Rouge, United States. In Metabolism, 20 Jun 2013
SCO also significantly decreased fatty acid synthase (FAS), HMG-CoA Reductase (HMGR), and Sterol regulatory element-binding protein 1c (SREBP1c), but not Carnitine palmitoyltransferase I (CPT-1) when compared with HFD group.
Targeting mitochondrial oxidative metabolism as an approach to treat heart failure.
Review
New
Edmonton, Canada. In Biochim Biophys Acta, Apr 2013
Carnitine palmitoyl transferase I (CPT1), fatty acid β-oxidation enzymes, and pyruvate dehydrogenase kinase (PDK) are examples of metabolic targets for the treatment of heart failure.
Maternal Dietary Restriction Alters Offspring's Sleep Homeostasis.
New
Tokushima, Japan. In Plos One, Dec 2012
DR adult offspring mice exhibited small but significant increases in the expression of hypothalamic peroxisome proliferator-activated receptor α (Pparα) and brain-specific carnitine palmitoyltransferase 1 (Cpt1c) mRNA, two genes involved in lipid metabolism.
Promoting lipid utilization with l-carnitine to improve oocyte quality.
Review
New
Adelaide, Australia. In Anim Reprod Sci, Sep 2012
Transport of activated fatty acids into mitochondria is catalyzed by carnitine palmitoyl transferase-I (CPTI) which also requires the metabolite carnitine.
MicroRNAs regulating lipid metabolism in atherogenesis.
Review
New
New York City, United States. In Thromb Haemost, Apr 2012
By repressing a variety of genes involved in cholesterol export and fatty acid oxidation, including ABCA1, CROT, CPT1, HADHB and PRKAA1, miR-33a/b act in concert with their host genes to boost cellular sterol levels.
Central mechanisms involved in the orexigenic actions of ghrelin.
Review
Australia. In Peptides, 2011
The downstream signaling involves a novel CaMKK-AMPK-CPT1-UCP2 pathway that enhances mitochondrial efficiency and buffers reactive oxygen species in order to maintain an appropriate firing response in NPY.
Ghrelin-mediated appetite regulation in the central nervous system.
Review
Kraków, Poland. In Peptides, 2011
However, it plays a key role in the metabolic changes of lipids, mainly those involving hypothalamic NOS, AMPK, CaMKK2, CPT1 and UCP2 proteins.
Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly.
GeneRIF
Baltimore, United States. In J Neurochem, 2011
CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet
Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex.
GeneRIF
Cleveland, United States. In J Biol Chem, 2011
strong protein-protein interaction between CPT1a, long chain acyl-CoA synthetase, and voltage-dependent anion channel
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.
GeneRIF
Edmonton, Canada. In Proc Natl Acad Sci U S A, 2011
Data show that the anorectic actions of central leptin or cerulenin are impaired in mice with brain CPT-1c deleted.
[Effects of fatigue and restraint stress on the expression of carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors in aorta of rats].
GeneRIF
Shijiazhuang, China. In Zhonghua Yi Xue Za Zhi, 2011
The protein expressions of CPT-I and PPARdelta decreased in excessive fatigue rats.
Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet.
GeneRIF
Foggia, Italy. In Plos One, 2010
The goal of the present study was to achieve more understanding on the modification/s of carnitinepalmitoyltransferase-I (CPT-I), the rate-limiting enzyme of the mitochondrial fatty acid beta-oxidation, during steatohepatitis.
Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.
Review
Impact
Edmonton, Canada. In Pharmacol Rev, 2010
Malonyl CoA inhibits carnitine palmitoyltransferase-1 (CPT-1), and it has been proposed that the substrate of CPT-1, long-chain acyl CoA(s), may act as a mediator(s) of appetite and energy balance.
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Impact
New York City, United States. In Nature, 2008
The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2.
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Impact
A Coruña, Spain. In Cell Metab, 2008
Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis induced by AMP-activated protein kinase (AMPK) resulting in decreased hypothalamic levels of malonyl-CoA and increased carnitine palmitoyltransferase 1 (CPT1) activity.
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Impact
Bethesda, United States. In Cell Metab, 2008
Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment.
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Impact
Durham, United States. In Cell Metab, 2008
These results were recapitulated in mice lacking malonyl-CoA decarboxylase (MCD), an enzyme that promotes mitochondrial beta-oxidation by relieving malonyl-CoA-mediated inhibition of carnitine palmitoyltransferase 1.
