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Phosphoinositide-3-kinase, class 2, alpha polypeptide

CPK
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, AGE, OUT
Papers on CPK
Hyaluronic acid modified pH-sensitive liposomes for targeted intracellular delivery of doxorubicin.
New
Vyas et al., Bilāspur, India. In J Liposome Res, Feb 2016
The major side-effect of conventional DOX formulation, i.e. cardiotoxicity was also estimated by measuring serum enzyme levels of LDH and CPK and found to be minimized with developed formulation.
Acylcarnitine profiles in HIV-exposed, uninfected neonates in the United States.
New
Summar et al., Boston, United States. In Aids Res Hum Retroviruses, Dec 2015
Mean ALT levels were slightly higher in those with abnormal ACP, but no differences in lactate, glucose or CPK were observed.
Evaluation of Prognostic Values of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Crimean-Congo Hemorrhagic Fever Patients.
New
Altay et al., Ankara, Turkey. In Jundishapur J Microbiol, Oct 2015
The significant differences between recovering patients and the patients who died, regarding Aspartate aminotransferase (AST), Creatine Phosphokinase (CPK), Lactate Dehydrogenase (LDH), Prothrombin Time (PT), activated Partial Thromboplastin time (aPTT), and thrombocyte and fibrinogen levels, were consistent with many clinical studies in the literature.
Bradykinin Impairs and HOE 140 does not Protect Rat Hindlimb Skeletal Muscle Against Tourniquet-induced Reperfusion Injury.
New
Piccinato et al., São Paulo, Brazil. In J Invest Surg, Oct 2015
The methods include analysis of enzymes (lactate dehydrogenase-LDH and creatinine phosphokinase-CPK), cell membrane marker of injury (malondialdeyde-MDA), recruitment of neutrophils (myeloperoxidase-MPO), and apoptosis index (immunohistochemistry TUNEL in situ peroxidase dead end).
Genome-wide survey and expression analysis of the calcium-dependent protein kinase gene family in cassava.
New
Peng et al., Haikou, China. In Mol Genet Genomics, Sep 2015
UNASSIGNED: Calcium-dependent protein kinases (CPKs) play important roles in regulating plant tolerance to abiotic stress and signal transduction; however, no data are currently available regarding the CPK family in cassava.
Daily Oxygen/O₃ Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise.
D'Amico et al., Napoli, Italy. In Oxid Med Cell Longev, 2014
The same doses resulted in decrease of LDH levels, CPK, TnI, and nitrotyrosine concentration in the heart and gastrocnemius tissues, arguing a beneficial effect of the ozone molecule against the fatigue induced by a prolonged high intensity exercise.
A Case of Docetaxel Induced Myositis and Review of the Literature.
Hussain et al., New York City, United States. In Case Report Rheumatol, 2014
Laboratory findings were notable for elevation in creatine phosphokinase (CPK), aldolase, and erythrocyte sedimentation rate (ESR); a magnetic resonance imaging (MRI) of her lower extremities showed evidence of bilateral muscle edema involving the anterior compartment muscles of the thighs.
Genome-Wide Identification of Calcium Dependent Protein Kinase Gene Family in Plant Lineage Shows Presence of Novel D-x-D and D-E-L Motifs in EF-Hand Domain.
Bae et al., Kyŏngsan, South Korea. In Front Plant Sci, 2014
Here, we reported the CPK gene family of 40 different plant species (950 CPK genes) and provided a unified nomenclature system for all of them.
Genome-wide gene phylogeny of CIPK family in cassava and expression analysis of partial drought-induced genes.
Peng et al., Haikou, China. In Front Plant Sci, 2014
However, no data is currently available about the CPK family in cassava.
[Prognostic factors in hantavirus infections].
Review
Kaya, Trabzon, Turkey. In Mikrobiyol Bul, 2014
High serum levels of white blood cells, blood urea nitrogen (BUN), creatinine phophokinase (CPK), C-reactive protein (CRP), prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer and INR (International normalized ratio) are prognostic factors that increase the mortality risk.
Lipid-lowering agents for nephrotic syndrome.
Review
Jiang et al., Chengdu, China. In Cochrane Database Syst Rev, 2012
Four studies reported creatinine phosphokinase (CPK).
Rhabdomyolosis and its pathogenesis.
Review
Zhang, Hangzhou, China. In World J Emerg Med, 2011
Since the necrosis and dissolution of muscle cells, entocytes such as myoglobin, creatine phosphokinase (CPK), electrolytes, proteins and non-protein substances were released into the plasma, the detection of the entocytes may contribute to the early diagnosis of rhabdomyolysis.
Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function.
GeneRIF
Oravecz et al., The Woodlands, United States. In Mol Cell Biol, 2011
PI3KC2alpha-deficient mice developed chronic renal failure and exhibited a range of kidney lesions, including glomerular crescent formation and renal tubule defects in early disease, which progressed to diffuse mesangial sclerosis.
PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways.
GeneRIF
Salcini et al., Copenhagen, Denmark. In J Cell Sci, 2011
These data suggest a general role for PI3KC2alpha in regulating physiologically relevant dynamin-independent internalization pathways.
Calcium and secondary CPK signaling in plants in response to herbivore attack.
Review
Maffei et al., Kyoto, Japan. In Biochem Biophys Res Commun, 2010
Here, we review the sequence of signal transductions triggered by herbivory-evoked Ca(2+) signaling leading to CPK actions for defense responses, and discuss in a comparative way the involvement of CPKs in the signal transduction of a variety of other biotic and abiotic stresses.
Cystin localizes to primary cilia via membrane microdomains and a targeting motif.
GeneRIF
Guay-Woodford et al., Birmingham, United States. In J Am Soc Nephrol, 2009
Analysis of deletion and chimeric constructs identified an AxEGG motif that is necessary to target and retain cystin in the cilium. Derangement of these localization motifs may lead to cystic kidney disease.
[Macroenzymes: macro-ASAT and macro-CPK. Two cases and literature review].
Review
Martinot et al., Colmar, France. In Rev Med Interne, 2009
CASE REPORTS: We report two cases: firstly, a macro-aspartate aminotransferase (macro-ASAT) discovered in an 82-year-old woman who presented with an isolated and persistent elevation of the ASAT activity that was discovered after sepsis, secondly, a macro-creatine-kinase (macro-CPK) diagnosed in a 62-year-old man after several years of investigations for a persistent CPK elevation.
Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation.
GeneRIF
Ren et al., Singapore, Singapore. In Biochem Biophys Res Commun, 2009
Taken together, these data suggest for the first time that in addition to class I PI3Ks in cancer, class II PIK3C2alpha can modulate hepatocellular carcinoma cell growth.
Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death.
GeneRIF
Mackeigan et al., Grand Rapids, United States. In Mol Cancer Res, 2008
Lowering the levels of PI3K-C2alpha in a number of cancer cell lines reduces their proliferation and cell viability.
Manipulation of myogenesis in vitro: reversible inhibition by DMSO.
Impact
Epstein et al., In Cell, 1979
DMSO (2%) inhibits the fusion of myoblasts to form multinucleate myotubes, the normal increases in activity of creatine phosphokinase (CPK) and acetylcholinesterase, and the synthesis of alpha-actin and acetylcholine receptor protein.
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