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Carboxypeptidase A6

CPAH, carboxypeptidase B
The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome.[provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: carboxypeptidase, ACID, Trypsin, HAD, CAN
Papers on CPAH
Evaluation of employing poly-lysine tags versus poly-histidine tags for purification and characterization of recombinant copper-binding proteins.
New
Xiao et al., Melbourne, Australia. In J Inorg Biochem, Jan 2016
The tag may be removed readily by the enzyme carboxypeptidase B to generate the native protein with no extra residues.
Active Compounds Against Anopheles minimus Carboxypeptidase B for Malaria Transmission-Blocking Strategy.
New
Kubera et al., Bangkok, Thailand. In J Med Entomol, Nov 2015
Carboxypeptidase B (CPB) in the midgut of Anopheline mosquitoes has been demonstrated to be essential for the sexual development of Plasmodium in the mosquito.
Selective modulation of thrombin-activatable fibrinolysis inhibitor (TAFI) activation by thrombin or the thrombin-thrombomodulin complex using TAFI-derived peptides.
New
Meijers et al., Amsterdam, Netherlands. In J Thromb Haemost, Nov 2015
The inhibition was TAFIa specific, because no effect on the homologous enzyme carboxypeptidase B was observed.
Structure of the complex of carboxypeptidase B and N-sulfamoyl-L-arginine.
New
Kuranova et al., Moscow, Russia. In Acta Crystallogr Sect F Struct Biol Commun, Oct 2015
Porcine pancreatic carboxypeptidase B (EC 3.4.23.6) was complexed with a stable transition-state analogue, N-sulfamoyl-L-arginine, in which an S atom imitates the sp(3)-hybridized carbon in the scissile-bond surrogate.
PI3-Kinase Inhibitor LY294002 Repressed the Expression of Thrombin-Activatable Fibrinolysis Inhibitor in Human Hepatoma HepG2 Cells.
Takada et al., In Biol Pharm Bull, 2014
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme biosynthesized in the liver and released into the blood circulation.
Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy.
GeneRIF
Malafosse et al., Genève, Switzerland. In Hum Mutat, 2012
CPA6 mutatins are genetically linked to an autosomal recessive familial form of febrile seizures and temporal lobe epilepsy (TLE), and are associated with sporadic TLE cases.
Laboratory diagnosis of acute pancreatitis: in search of the Holy Grail.
Review
Cervellin et al., Parma, Italy. In Crit Rev Clin Lab Sci, 2012
Some interesting biomarkers have been also suggested (e.g., serum and urinary trypsinogen-1, -2 and -3, phospholipase A2, pancreatic elastase, procalcitonin, trypsinogen activated protein, activation peptide of carboxypeptidase B, trypsin-2-alpha1 antitrypsin complex and circulating DNA), but none of them has found widespread application for a variety of reasons, including the inferior diagnostic accuracy when compared with the traditional enzymes, the use of cumbersome techniques, or their recent discovery.
The plasminogen receptor, Plg-R(KT), and macrophage function.
Review
Parmer et al., Los Angeles, United States. In J Biomed Biotechnol, 2011
We have used a proteomics approach combining targeted proteolysis with carboxypeptidase B and multidimensional protein identification technology, MudPIT, and a monocyte progenitor cell line to identify a novel transmembrane protein, the plasminogen receptor, Plg-R(KT).
Substrate specificity of human carboxypeptidase A6.
GeneRIF
Fricker et al., New York City, United States. In J Biol Chem, 2011
Substrate specificity of human carboxypeptidase A6
On the discovery of precursor processing.
Review
Steiner, Chicago, United States. In Methods Mol Biol, 2010
The subsequent discovery of a similar biosynthetic pathway in yeast led to the identification of eukaryotic families of specialized processing subtilisin-like endopeptidases coupled with carboxypeptidase B-like exopeptidases.
Progress in metallocarboxypeptidases and their small molecular weight inhibitors.
Review
Avilés et al., Barcelona, Spain. In Biochimie, 2010
Plasma carboxypeptidase B is a biological target for therapy because of its involvement in the coagulation/fibrinolysis processes.
Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.
GeneRIF
Leung et al., Stanford, United States. In Arthritis Rheum, 2009
Thrombin activation of osteopontin (OPN) (resulting in OPN-R) and its subsequent inactivation by thrombin-activatable carboxypeptidase B (generating OPN-L) occurs locally within inflamed joints in rheumatoid arthritis.
Characterization of carboxypeptidase A6, an extracellular matrix peptidase.
GeneRIF
Fricker et al., New York City, United States. In J Biol Chem, 2008
CPA6 may have a role in the regulation of neuropeptides in the extracellular environment within the olfactory bulb and other parts of the brain
[Role of carboxypeptidase in regulation of fibrinolysis].
Review
Kudinov et al., In Ukr Biokhim Zh (1999), 2004
Data are cited about carboxypeptidase B level changes under different physiological conditions and possible methods of fibrinolysis reactions strengthening by means of influence on activity of that carboxypeptidase.
A peptidase gene in chromosome 8q is disrupted by a balanced translocation in a duane syndrome patient.
GeneRIF
Dallapiccola et al., Roma, Italy. In Invest Ophthalmol Vis Sci, 2002
The CPAH gene was interrupted in a patient with DURS carrying a translocation break point in the DURS1 region on chromosome 8q13.
Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.
Impact
Sassard et al., Paris, France. In Nat Genet, 1993
Significant linkage was established between diastolic blood pressure and a microsatellite marker of the renin gene (REN) on rat chromosome 13, and between pulse pressure and the carboxypeptidase B gene (CPB) on chromosome 2.
Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing.
Impact
Bussey et al., In Cell, 1987
The yeast KEX1 gene product has homology to yeast carboxypeptidase Y.
Cloning and sequence analysis of cDNA for bovine carboxypeptidase E.
Impact
Herbert et al., In Nature, 1986
Carboxypeptidase E (enkephalin convertase) was first identified as the carboxypeptidase B-like enzyme involved in the biosynthesis of enkephalin in bovine adrenal chromaffin granules.
Glycyl glutamine, an inhibitory neuropeptide derived from beta-endorphin.
Impact
Wolstencroft et al., In Nature, 1983
These derivatives of beta-endorphin are released by an endopeptidase that appears to catalyse cleavage on the carboxyl side of paired lysine residues, followed by the action of a carboxypeptidase B-like enzyme (Fig. 1).
An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.
Impact
Udenfriend et al., In Science, 1980
Digestion with trypsin and carboxypeptidase B yields [Met]enkephalin and [Leu]enkephalin in a ratio of almost 7 to 1.
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