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Cytochrome c oxidase subunit VIIa polypeptide 2

COX7AL, Cox7a2, COX VIIa-L, VIIa-L, cytochrome c oxidase subunit VIIa-L
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: SP1, SET, ACID, Nuclear Respiratory Factor 1, HAD
Papers on COX7AL
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Tanaka et al., Tokyo, Japan. In Bioinformation, 2014
ABBREVIATIONS: ATP5I - ATP synthase H+ transporting mitochondrial F0 complex subunit E, ATP5J - ATP synthase H+ transporting mitochondrial F0 complex subunit F6, BAD - Bcl-2-associated death promoter, BAX - Bcl-2-associated x protein, Bcl-2 - B-cell lymphoma 2, BDNF - brain derived neurotrophic factor, COX5B - Cytochrome c oxidase subunit Vb, COX7A2 - cytochrome c oxidase subunit VIIa polypeptide 2, DLK - dual leucine zipper-bearing kinase, GABA - Gamma aminobutyric acid, IL-8 - Interleukin 8, NDUFA1 - NADH dehydrogenase 1 alpha subcomplex 1, NDUFB2 - NADH dehydrogenase1 beta subcomplex 2, NDUFS4 - NADH dehydrogenase Fe-S protein 4, NGF - nerve growth factor, PPP2R5C - protein phosphatase 2 regulatory subunit B gamma, PSMA3 - proteasome subunit alpha type 3, PSMA7 - proteasome subunit alpha type 7, PSMB1 - proteasome subunit beta type 1, PSMB6 - proteasome subunit beta type 6, PSMB7 - proteasome subunit beta type 7, PSMC2 - proteasome 26S subunit ATPase 2, PSMC5 - proteasome 26S subunit ATPase 5, SLC6A4 - solute carrier family 6 member 4, TNFa - tumor necrosis factor a, UBE2A - ubiquitinconjugating enzyme E2A, UCRC - ubiquinol-cytochrome c reductase complex, UFC1 - ubiquitin-fold modifier conjugating enzyme 1, UQCRQ - ubiquinol-cytochrome c reductase complex III subunit VII, USP14 - ubiquitin specific protease 14.
Differential gene expression in obese pregnancy.
Delles et al., Glasgow, United Kingdom. In Pregnancy Hypertens, 2014
In whole blood, differential expression (p<0.05) of six genes (ANGPTL, COX7A2, EIF3A, PTS, CISD1 and GLRX) was identified between lean and non-lean pregnant women by microarray.
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.
Walch et al., München, Germany. In J Proteomics, 2012
Using mass spectrometry for protein identification and validating the results by immunohistochemistry on an independent validation set, we could identify two of 60 differentially expressed m/z species between Barrett's adenocarcinoma and the precursor lesion: COX7A2 and S100-A10.
High-resolution melting analysis of 15 genes in 60 patients with cytochrome-c oxidase deficiency.
Tesarova et al., Praha, Czech Republic. In J Hum Genet, 2012
Nine novel variants were identified in exons and adjacent intronic regions of COX4I2, COX6A1, COX6A2, COX7A1, COX7A2 and COX10 using high-resolution melting (HRM) analysis.
Coordination of cytochrome c oxidase gene expression in the remodelling of skeletal muscle.
Moyes et al., Kingston, Canada. In J Exp Biol, 2011
Some subunits failed to increase in one (goldfish COX7A2, dace COX6A2) or both (COX7B, COX6B2) species.
Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo.
Ling et al., Malmö, Sweden. In Eur J Endocrinol, 2011
RESULTS: Two common variants were identified in the DGI, where the major C-allele of rs606164, adjacent to NADH dehydrogenase (ubiquinone) 1 subunit C2 (NDUFC2), and the minor G-allele of rs1323070, adjacent to cytochrome c oxidase subunit VIIa polypeptide 2 (COX7A2), showed nominal associations with decreased glucose-stimulated insulin secretion (P=0.0009,
[P70S6K is involved in the inhibition of testosterone production in TM3 mouse Leydig cells overexpressing Cox7a2].
Guo et al., Beijing, China. In Zhonghua Nan Ke Xue, 2011
Cox7a2 decreased P70S6K phosphorylation, reduced StAR expression and consequently inhibited LH-induced testosterone biosynthesis in the TM3 Leydig cells.
Polymorphisms in mitochondrial genes and prostate cancer risk.
Thibodeau et al., Rochester, United States. In Cancer Epidemiol Biomarkers Prev, 2008
These seven SNPs (rs17184211, rs4147684, rs4233367, rs2070902, rs3829037, rs7830235, and rs1203213) are located in genes MTRR, NDUFA9, NDUFS2, NDUFB9, and COX7A2, respectively.
Cox7a2 mediates steroidogenesis in TM3 mouse Leydig cells.
Guo et al., Beijing, China. In Asian J Androl, 2006
Cox7a2 inhibited lutropin-induced StAR protein expression, and consequent testosterone production
[Studies on the testis regression related gene profile in aged male].
Lue et al., Beijing, China. In Beijing Da Xue Xue Bao, 2003
It is interesting to find that respiratory chain related gene cox7a2 was up-regulated and atp50 down-regulated significantly which as further confirmed by RT-PCR analysis with sequence analysis in the products of the RT-PCR by T-A cloning.
Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development.
Papaconstantinou et al., Galveston, United States. In Biochim Biophys Acta, 2003
The protein level for COX7AL was decreased early during the acute phase.
Embryotrophic factor-3 from human oviductal cells affects the messenger RNA expression of mouse blastocyst.
Yeung et al., Hong Kong, Hong Kong. In Biol Reprod, 2003
The differential expression of seven of these mRNAs (ezrin, heat shock 70-kDa protein, cytochrome c oxidase subunit VIIa-L precursor, proteinase-activated receptor 2, eukaryotic translation initiation factor 2beta, cullin 1, and proliferating cell nuclear antigen) was confirmed by semiquantitative RT-PCR.
Characterization of the murine gene for subunit VIIaL of cytochrome c oxidase.
Cogné et al., Limoges, France. In C R Acad Sci Iii, 2001
The gene for murine cytochrome c oxidase subunit VIIa-L (Cox7aL) and its promoter region were isolated, sequenced and analysed.
Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene.
Kadenbach et al., Marburg an der Lahn, Germany. In Biochim Biophys Acta, 2000
The gene for human cytochrome c oxidase subunit VIIa liver isoform (COX7AL) was isolated and its sequence determined and analyzed.
Tissue-specific expression and mapping of the Cox7ah gene in mouse.
Grossman et al., Detroit, United States. In Genomics, 1998
Interspecies amino acid comparisons indicate that mouse COX VIIa-H protein displays 82.5 and 70.9% identity with the bovine and human heart isoforms of COX VIIa, but only 53.7% identity with the paralogous mouse liver isoform (COX VIIa-L).
Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene.
Robinson et al., Toronto, Canada. In Genome, 1997
119: 299-305, 1992) that COX VIIa-L sequences are located on chromosomes 4 and 14, we found that COX VIIa-L related sequences reside on chromosome 6, while an additional COX VIIa-L cross-reacting sequence psi-gene) was located on chromosome 4.
Cytochrome c oxidase subunit VIIa liver isoform. Characterization and identification of promoter elements in the bovine gene.
Grossman et al., Wayne, United States. In J Biol Chem, 1996
Cytochrome c oxidase subunit VIIa is specified by two nuclear genes, one (COX7AH) producing a heart/muscle-specific isoform and the other (COX7AL) a form expressed in all tissues.
Structural organization and evolution of the liver isoform gene for bovine cytochrome c oxidase subunit VIIa.
Grossman et al., Detroit, United States. In Genomics, 1993
We have isolated and characterized the L-isoform gene (COX7aL).
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