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Cytochrome c oxidase subunit IV isoform 1

COX4, COX IV, cytochrome c oxidase subunit IV
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PGC, HAD, CAN, ACID, TFAM
Papers using COX4 antibodies
Shuttling and translocation of heterotrimeric G proteins and Ras.
Supplier
Bonini Marcelo G., In PLoS ONE, 2008
... For positive control CoxIV antibody (Abcam Biosciences cat no: 33985) ...
The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.
Supplier
Polymenis Michael, In PLoS ONE, 2008
... The antibodies against cytochrome c, Cl-caspase-3, Cl-caspase-9, Cl-PARP, GPx1, CoxIV were purchased from Cell Signaling (Danvers, MA) and complex-I, ...
FireDock: fast interaction refinement in molecular docking.
Supplier
Jin Dong-Yan, In PLoS ONE, 2006
... (Stressgen Biotechnologies), rabbit anti-His probe, rabbit anti-Bax N-20 (Santa Cruz), rabbit anti-eIF2α, rabbit anti-phospho-eIF2α/Ser51, rabbit anti-COX IV (Cell Signaling Technology), mouse anti-TBP (Abcam), ...
Puerarin Decreases Lens Epithelium Cell Apoptosis Induced Partly By Peroxynitrite In Diabetic Rats.
Supplier
Morty Rory Edward, In PLoS ONE, 2005
... A mouse anti-cytochrome oxidase IV (COXIV) monoclonal antibody was purchased from Abcam (Cambridge, UK) ...
Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.
Supplier
Lightowlers Bob, In PLoS ONE, 2004
... against Hsp60, Calnexin or cytochrome C were from Stressgen (Farmingdale, NY, USA), against active caspase-3 or COX IV from Cell Signaling (Danvers, MA, USA), against ...
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Papers on COX4
Chronic Arsenic Exposure-Induced Oxidative Stress is Mediated by Decreased Mitochondrial Biogenesis in Rat Liver.
New
Kumar et al., Rohtak, India. In Biol Trace Elem Res, Feb 2016
The messenger RNA (mRNA) expression of mitochondrial and nuclear-encoded subunits of complexes I (ND1 and ND2) and IV (COX I and COX IV) was downregulated in arsenic-treated rats only.
Copper and hypoxia modulate transcriptional and mitochondrial functional-biochemical responses in warm acclimated rainbow trout (Oncorhynchus mykiss).
New
Kamunde et al., Charlottetown, Canada. In Environ Pollut, Feb 2016
Analyses of transcripts encoding for proteins involved in mitochondrial respiration (cytochrome c oxidase subunits 4-1 and 2: COX4-1 and COX4-2), metal detoxification/stress response (metallothioneins A and B: MT-A and MT-B) and energy sensing (AMP-activated protein kinase α1: AMPKα1) were done in liver mitochondria, and in whole liver and gill tissues by RT-qPCR.
The mammalian homologue of yeast AFG1 ATPase (Lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.
New
Stiburek et al., Praha, Czech Republic. In Biochem J, Feb 2016
We demonstrate that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4, COX5A and COX6A, and is required for normal activity of complexes III and IV of respiratory chain.
Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice.
New
Yan et al., Chongqing, China. In Neurochem Res, Jan 2016
Furthermore, the intracellular ATP and the COX IV activity of APP/PS1 neurons were increased after 30 μM NaHS treatment, while the ROS level was decreased and the MMP was stabilized.
Combination therapy with metformin and coenzyme Q10 in murine experimental autoimmune arthritis.
New
Cho et al., Seoul, South Korea. In Immunopharmacol Immunotoxicol, Jan 2016
We also found that the expression of JC-1 and COX IV were enhanced by treatment with the combination of Met and CoQ10.
Gene expression profiling indicates an increased capacity for proline, serine, and ATP synthesis and mitochondrial mass by the liver of steers grazing high vs. low endophyte-infected tall fescue.
New
Matthews et al., In J Anim Sci, Dec 2015
High toxic endophyte tall fescue-mixed pasture steers had increased ( ≤ 0.022) expression of genes critical for increased (1) Pro () and Ser () synthesis, (2) shunting of AA carbons into pyruvate () and ATP synthesis (, , , COX4, , and ), and (3) mitochondrial mass (COX4).
FOXO1 and GSK-3β Are Main Targets of Insulin-Mediated Myogenesis in C2C12 Muscle Cells.
New
Orzechowski et al., Warsaw, Poland. In Plos One, Dec 2015
Once FOXO1 and GSK-3β activities were inhibited the rise in Cox-1 gene action and nuclear encoded cytochrome c oxidase subunit IV (COX IV) expressions were observed, even though some mRNA and protein results varied.
Isolation of Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High Throughput Microplate Respiratory Measurements.
Frisard et al., Virginia, South Africa. In J Vis Exp, 2014
In addition, Western blot analysis in isolated mitochondria resulted in the faint expression of the cytosolic protein, GAPDH, and the robust expression of the mitochondrial protein, COXIV.
Coupled electron and proton transfer reactions during the O→E transition in bovine cytochrome c oxidase.
GeneRIF
Stuchebrukhov et al., Davis, United States. In Biochim Biophys Acta, 2012
Studies suggest for the His291 model of proton pumping in cytochrome c oxidase (CcO).
Allosteric interactions and proton conducting pathways in proton pumping aa(3) oxidases: heme a as a key coupling element.
GeneRIF
Papa et al., Foggia, Italy. In Biochim Biophys Acta, 2012
Studies indicate that mutational amino acid replacement in proton channels, at the negative (N) side of membrane-inserted prokaryotic aa(3) oxidases, as well as Zn(2+) binding at this site in the bovine oxidase, uncouples proton pumping.
Resonance Raman applications in investigations of cytochrome c oxidase.
GeneRIF
Ogura, Japan. In Biochim Biophys Acta, 2012
Studies indicate that time-resolved resonance Raman (RR) spectroscopy of whole mitochondria identified a band at 571cm(-1) arising from the oxygenated intermediate at Deltat=0.4, 0.6 and 1.4ms.
Kinetic studies of the reactions of O(2) and NO with reduced Thermus thermophilus ba(3) and bovine aa(3) using photolabile carriers.
GeneRIF
Szundi et al., Santa Cruz, United States. In Biochim Biophys Acta, 2012
Studies indicate that nitric oxide (NO) binding to reduced ba(3) and bovine cytochrome aa3.
Structural studies on bovine heart cytochrome c oxidase.
GeneRIF
Mochizuki et al., Japan. In Biochim Biophys Acta, 2012
Studies indicate that X-ray structure of heart cytochrome c oxidase (CcO) suggest that O(2) molecules are transiently trapped at the Cu(B) site before binding to Fe(a3)(2+) to provide O(2)(-).
Cytochrome c oxidase and its role in neurodegeneration and neuroprotection.
Review
Arnold, Aachen, Germany. In Adv Exp Med Biol, 2011
At high ATP/ADP ratios, ADP is exchanged for ATP at the matrix side of COX IV-1 leading to an inhibition of COX activity, thus enabling COX to sense the energy level and to adjust ATP synthesis to energy demand.
Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning.
Review
Semenza, Baltimore, United States. In Biochim Biophys Acta, 2011
HIF-1 reduces ROS production under hypoxic conditions by multiple mechanisms including: a subunit switch in cytochrome c oxidase from the COX4-1 to COX4-2 regulatory subunit that increases the efficiency of complex IV; induction of pyruvate dehydrogenase kinase 1, which shunts pyruvate away from the mitochondria; induction of BNIP3, which triggers mitochondrial selective autophagy; and induction of microRNA-210, which blocks assembly of Fe/S clusters that are required for oxidative phosphorylation.
Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation.
Impact
Manfredi et al., New York City, United States. In Cell Metab, 2011
We find that PKA-mediated phosphorylation of a COX subunit dictates mammalian mitochondrial energy fluxes and identify the specific residue (S58) of COX subunit IV-1 (COXIV-1) that is involved in this mechanism of metabolic regulation.
Axonal protein synthesis and the regulation of local mitochondrial function.
Review
Aschrafi et al., Bethesda, United States. In Results Probl Cell Differ, 2008
One of these miRs (miR-338) targets cytochrome c oxidase IV (COXIV) mRNA.
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.
Review
Semenza, Baltimore, United States. In Biochem J, 2007
Secondly, the subunit composition of COX is altered in hypoxic cells by increased expression of the COX4-2 subunit, which optimizes COX activity under hypoxic conditions, and increased degradation of the COX4-1 subunit, which optimizes COX activity under aerobic conditions.
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.
Impact
GeneRIF
Semenza et al., Baltimore, United States. In Cell, 2007
Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation.
Molecular evolution of aerobic energy metabolism in primates.
Review
Goodman et al., Detroit, United States. In Mol Phylogenet Evol, 2001
Besides clear evidence that adaptive evolution occurred for cytochrome c and subunits of complexes III (e.g., cytochrome c(1)) and IV (e.g., COX2 and COX4), modest rate accelerations in the lineage that led to humans are seen for other subunits of both complexes.
More papers using COX4 antibodies
Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues.
Supplier
Chung Sookja, In PLoS ONE, 2000
... Polyclonal anti-CoxIV was from abcam (UK) ...
Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca2+-induced inhibition of substrate oxidation
Supplier
Mongin Alexander A., In PLoS ONE, 1998
... Cyp-D antibody was purchased from Abcam (Cambridge, MA, USA), cytochrome c oxidase IV (COX IV) antibody was purchased from Santa Cruz Biotechnology (Beijing, China), and horseradish ...
Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose
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Johannes Ludger, In PLoS ONE, 1983
... The following primary antibodies were used: rabbit anti-EGFR antibody (Cell Signaling Technology); rabbit anti-COX IV antibody (Cell Signaling Technology); rabbit anti-p38 antibody ...
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