A synthetic gene circuit for measuring autoregulatory feedback control.
Barcelona, Spain. In Integr Biol (camb), Feb 2016
We find that RBP Puf3 does not natively participate in any direct or indirect feedback regulation, but that replacing the native 3'UTR with that of COX17 generates an auto-regulatory negative feedback loop which reduces gene expression noise.
Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.
Utrecht, Netherlands. In J Trace Elem Med Biol, 2015
Expression of genes involved in copper metabolism (COX17, CCS, ATOX1, MT1A, CP, ATP7A, ATP7B, ) and oxidative stress (SOD1, catalase, GPX1 ) was measured by qPCR.
Redox regulation of SCO protein function: controlling copper at a mitochondrial crossroad.
Saskatoon, Canada. In Antioxid Redox Signal, 2010
To date, a total of 8 soluble (COX17, COX19, COX23, PET191, CMC1-4) and 3 integral membrane (COX11, SCO1, SCO2) accessory proteins with cysteine-containing domains that reside within the mitochondrial intermembrane space (IMS) have been identified in yeast, all of which have human orthologues.
Mitochondrial copper metabolism and delivery to cytochrome c oxidase.
Miami, United States. In Iubmb Life, 2008
Recent studies, mostly performed in the yeast Saccharomyces cerevisiae, have provided new clues about 1) the source of the copper used for COX metallation; 2) the roles of Sco1p and Cox11p, the proteins involved in the direct delivery of copper to the Cu(A) and Cu(B) sites, respectively; 3) the action mechanism of Cox17p, a copper chaperone that provides copper to Sco1p and Cox11p; 4) the existence of at least four Cox17p homologues carrying a similar twin CX(9)C domain suggestive of metal binding, Cox19p, Cox23p, Pet191p and Cmc1p, that could be part of the same pathway; and 5) the presence of a disulfide relay system in the intermembrane space of mitochondria that mediates import of proteins with conserved cysteines motifs such as the CX(9)C characteristic of Cox17p and its homologues.
Redox pathways of the mitochondrion.
Los Angeles, United States. In Antioxid Redox Signal, 2006
A redox pathway (Mia40p and Erv1p) mediates the import of intermembrane space proteins such as the small Tim proteins, Cox17p, and Cox19p, which have disulfide bonds.