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Nuclear receptor subfamily 2, group F, member 1

COUP Transcription Factor I, COUP-TF, COUP-TFI, COUP-TFII, COUP Transcription Factor II, ARP-1
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, MANF, TCF, V1a
Papers on COUP Transcription Factor I
Metabolome analyses uncovered a novel inhibitory effect of acyclic retinoid on aberrant lipogenesis in a mouse diethylnitrosamine-induced hepatic tumorigenesis model.
New
Kojima et al., Gifu, Japan. In Cancer Prev Res (phila), Feb 2016
As a molecular mechanism of ACR's effect to prevent the aberrant lipogenesis, microarray analysis identified that a key transcription regulator of both embryogenesis and tumorigenesis, COUP-TFII (COUP transcription factor 2), also known as NR2F2, was associated with the metabolic effect of ACR in human HCC cells.
Shear stress, arterial identity and atherosclerosis.
New
Jones et al., Montréal, Canada. In Thromb Haemost, Jan 2016
Notch1/4, Notch ligand delta-like 4 (Dll4), and Notch downstream effectors are typically expressed in arterial cells along with EphrinB2, whereas chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and EphB4 characterise vein endothelial cells.
Choose your destiny: Make a cell fate decision with COUP-TFII.
Review
New
Tsai et al., Houston, United States. In J Steroid Biochem Mol Biol, Jan 2016
Emerging evidence demonstrates that the orphan nuclear receptor COUP-TFII serves as a key regulator in determining the cell identity during embryonic development.
Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms.
Review
New
Haak et al., Amsterdam, Netherlands. In Prenat Diagn, Jun 2015
Fifteen candidate genes involved in both cardiac and lymphatic development were identified: Adrenomedullin; Chicken ovalbumin upstream promoter-transcription factor 2 (COUP-TFII); Cyp51; Ephrin-B2; Forkhead box protein C2 (Foxc2); Nuclear factor of activated T cells, cytoplasmic 1 (Nfatc1); Neurofibromatosis type 1 (Nf1); Phosphoinositide 3-kinase encoding isoform p110α (Pik3ca); Podoplanin; Prospero-related homeobox 1 (Prox1); T-box 1 (Tbx1); Tyrosine kinase with immunoglobulin-like and endothelial growth factor-like domains 1 (Tie1); vascular endothelial growth factor (Vegf)-A; Vegf receptor-3 (Vegfr-3); and Vascular endothelial zinc finger 1 (Vezf1).
The molecular regulation of arteriovenous specification and maintenance.
Review
New
Wythe et al., Toronto, Canada. In Dev Dyn, Mar 2015
These include Notch and Notch-regulated transcription factors (e.g., HEY and HES), SOX factors, Forkhead factors, β-Catenin, ETS factors, and COUP-TFII.
The role of the orphan nuclear receptor COUP-TFII in tumorigenesis.
Review
Tsai et al., Houston, United States. In Acta Pharmacol Sin, 2015
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2).
Screening of Transcription Factors Involved in Fetal Hemoglobin Regulation Using Phylogenetic Footprinting.
Bonini-Domingos et al., Ribeirão Preto, Brazil. In Evol Bioinform Online, 2014
Of these motifs, 13 showed relation to Hb F regulation: cell division cycle-5 (CDC5), myelo-blastosis viral oncogene homolog (c-MYB), transcription factor CP2 (TFCP2), GATA binding protein 1 (GATA-1), GATA binding protein 2 (GATA-2), nuclear factor erythroid 2 (NF-E2), nuclear transcription factor Y (NF-Y), runt-related transcription factor 1 (RUNX-1), T-cell acute lymphocytic leukemia 1 (TAL-1), YY1 transcription factor (YY1), beta protein 1 (BP1), chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), and paired box 1 (PAX-1).
Venous Endothelial Marker COUP-TFII Regulates the Distinct Pathologic Potentials of Adult Arteries and Veins.
Dai et al., Troy, United States. In Sci Rep, 2014
In this study, we discovered that COUP-TFII, a transcription factor critical for establishing the venous identity during embryonic vascular development, also regulates the pathophysiological functions of adult blood vessels, especially those directly related to vascular diseases.
The Anti-Adipogenic Potential of COUP-TFII Is Mediated by Downregulation of the Notch Target Gene Hey1.
Lijnen et al., Leuven, Belgium. In Plos One, 2014
BACKGROUND: Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily and may contribute to the pathogenesis of obesity.
The critical roles of COUP-TFII in tumor progression and metastasis.
Review
Tsai et al., Shanghai, China. In Cell Biosci, 2013
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily.
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.
Impact
Tsai et al., Houston, United States. In Nature, 2013
Here we show that COUP transcription factor II (COUP-TFII, also known as NR2F2), a member of the nuclear receptor superfamily, serves as a key regulator to inhibit SMAD4-dependent transcription, and consequently overrides the TGF-β-dependent checkpoint for PTEN-null indolent tumours.
Chicken ovalbumin upstream promoter transcription factor II regulates renin gene expression.
GeneRIF
Todorov et al., Dresden, Germany. In J Biol Chem, 2012
Data show that COUP-TFII is involved in the control of renin gene expression.
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.
GeneRIF
Tsai et al., Houston, United States. In Development, 2012
The results showed, for the first time, that COUP-TFII plays a central role in the specification of metanephric fate and in the maintenance of metanephric mesenchyme proliferation and survival by acting as a crucial regulator of Eya1 and Wt1 expression.
Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity.
GeneRIF
Koh et al., Kwangju, South Korea. In J Biol Chem, 2012
COUP-TFII negatively regulates osteoblast differentiation via interaction with Runx2, and during the differentiation state, BMP2-induced Runx2 represses COUP-TFII expression and promotes osteoblast differentiation.
Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity.
GeneRIF
Vasseur-Cognet et al., Paris, France. In Plos One, 2011
The C-allele at rs3743462 was associated with increased NR2F2 binding and decreased NR2F2 gene expression.
Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.
GeneRIF
Klinge et al., Louisville, United States. In Plos One, 2011
nucleolin plays a coregulatory role in transcriptional regulation of the tumor suppressor RARB2 by COUP-TFII
Coup d'Etat: an orphan takes control.
Review
Impact
Tsai et al., United States. In Endocr Rev, 2011
Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2).
The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism.
Impact
GeneRIF
Tsai et al., Houston, United States. In Cell Metab, 2009
The chicken ovalbumin upstream promoter transcription factor II regulates adipogenesis by regulating the key molecules in adipocyte development and can serve as a target for regulating energy metabolism.
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.
Impact
GeneRIF
Tsai et al., Houston, United States. In Nature, 2005
COUP-TFII has a critical role in repressing Notch signalling to maintain vein identity, which suggests that vein identity is under genetic control and is not derived by a default pathway
Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase.
Impact
Tsai et al., Houston, United States. In Science, 1998
A Sonic hedgehog (Shh) response element was identified in the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promoter that binds to a factor distinct from Gli, a gene known to mediate Shh signaling.
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