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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mitogen-activated protein kinase kinase kinase 8

Cot, Tpl2
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: ERK, CAN, HAD, ACID, NF-kappaB
Papers using Cot antibodies
R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.
Supplier
Georges Michel, In PLoS Genetics, 2008
... Human Cot-1 DNA (Invitrogen/Life Technologies) was used at a mass ...
Phostensin caps to the pointed end of actin filaments and modulates actin dynamics
Supplier
He Ping et al., In Journal of Cancer, 2008
... in 5-mL pre-hybridization solution (HYB125.GF, Research Genetics) with 5-µl Poly(dA) (POLYA.GF, Research Genetics) and 5-µl Cot-1 DNA (15279-011, Life Technologies) at 42ºC for 2 to ...
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.
Supplier
Blachier François, In PLoS ONE, 2007
... Antibodies against total ERK1/2 (Cat# Sc-94) and Tpl2 (cat# Sc-720) were obtained from Santa Cruz Biotechnology.
Resveratrol induces apoptosis in human esophageal carcinoma cells
Supplier
Chen K Y et al., In British Journal of Cancer, 2002
... Oligo-dT, poly-dA, dNTPs, Superscript™ II reverse transcriptase, Cot-1 DNA, MicroHyb hybridisation solution were purchased from Invitrogen Life Technologies (Baltimore, MD, USA) ...
Papers on Cot
Epigenomics and bolting tolerance in sugar beet genotypes.
New
Maury et al., Tienen, Belgium. In J Exp Bot, Jan 2016
Using Cot fractionation followed by 454 sequencing of the isolated low-copy DNA, 6231 contigs were obtained that were used along with public sugar beet DNA sequences to design custom Agilent microarrays for expression (56k) and methylation (244k) analyses.
MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas.
Mechta-Grigoriou et al., Paris, France. In Nat Commun, 2014
Here we demonstrate that an additional MAP3K, MAP3K8 (TPL-2/COT), accumulates in high-grade serous ovarian carcinomas (HGSCs) and is a potential prognostic marker for these tumours.
Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST.
Brown et al., Vancouver, Canada. In Genome Biol, 2014
RESULTS: Localization of XIST, depletion of Cot-1 RNA, perinuclear localization, and ubiquitination of H2A occurs at all sites examined, while recruitment of H3K9me3 was not observed.
Repetitive sequences: the hidden diversity of heterochromatin in prochilodontid fish.
Feldberg et al., Manaus, Brazil. In Comp Cytogenet, 2014
The present study sought to characterize repetitive DNA sequences in the genomes of Semaprochilodus insignis (Jardine & Schomburgk, 1841) and Semaprochilodus taeniurus (Valenciennes, 1817) and identify regions of conserved syntenic blocks in this genome fraction of three species of Prochilodontidae (Semaprochilodus insignis, Semaprochilodus taeniurus, and Prochilodus lineatus (Valenciennes, 1836) by cross-FISH using Cot-1 DNA (renaturation kinetics) probes.
Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice.
Wang et al., Boston, United States. In J Exp Clin Cancer Res, 2014
BACKGROUND: Tumor progression locus 2 (TPL2), a serine-threonine kinase, functions as a critical regulator of inflammatory pathways and mediates oncogenic events.
Accounting for genetic and environmental confounds in associations between parent and child characteristics: a systematic review of children-of-twins studies.
Review
Eley et al., London, United Kingdom. In Psychol Bull, 2014
One technique for disentangling genetic from environmental effects is the children-of-twins (COT) method.
TPL2 signalling: from Toll-like receptors-mediated ERK1/ERK2 activation to Cystic Fibrosis lung disease.
Review
Rousseau et al., Montréal, Canada. In Int J Biochem Cell Biol, 2014
The protein kinase Tumour Progression Locus 2 (TPL2) is a key molecule in relaying inflammatory stimuli to ERK1/ERK2 MAPKs.
The biology of A20-binding inhibitors of NF-kappaB activation (ABINs).
Review
Beyaert et al., In Adv Exp Med Biol, 2013
Additional ABIN functions have been reported such as inhibition of TNF-induced hepatocyte apoptosis, regulation of HIV-1 replication for ABIN-1, and Tumor Progression Locus 2 (TPL-2)-mediated Extracellular signal-Regulated Kinase (ERK) activation for ABIN-2.
Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS).
Review
Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis (ISTH) et al., Sapporo, Japan. In J Thromb Haemost, 2013
Coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS) occurs as a result of increased activation of the thrombomodulin and protein C pathways, leading to the suppression of coagulation and activation of fibrinolysis.
Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.
GeneRIF
Ley et al., London, United Kingdom. In Mol Cell Biol, 2012
The Nfkb1(SSAA) mutation prevented the agonist-induced release of Tpl-2 from its inhibitor p105, which blocked activation of ERK by lipopolysaccharide and tumor necrosis factor.
Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein.
GeneRIF
Mikoshiba et al., Tokyo, Japan. In Mol Cell Biol, 2012
Cot activity in osteoclasts was enhanced via cell-cell interaction with osteoblasts, and Cot promoted Ca(2+) oscillation/calcineurin-independent osteoclastogenesis by increasing NFATc1 stability through phosphorylation.
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.
GeneRIF
Tsichlis et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
IL-10 levels and regulatory T-cell numbers were lower in the intestines of Tpl2(-/-) mice, independent of Apc and polyp status, suggesting that they were responsible for the initiation of the enhancement of tumorigenesis caused by the ablation of Tpl2.
Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?
GeneRIF
Steinhoff et al., Berlin, Germany. In Mucosal Immunol, 2012
knock-out mice display ameliorated experimental colitis
Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease.
GeneRIF
Banerjee et al., Melbourne, Australia. In Plos One, 2011
We have failed to find any significant role for Tpl2 in regulating obesity-associated metabolic disorders.
Molecular therapeutic advances in personalized therapy of melanoma and non-small cell lung cancer.
Review
McArthur et al., Australia. In J Pers Med, 2011
Mechanisms of drug resistance in melanoma to vemurafenib do not involve mutations in BRAF itself but are associated with a variety of molecular changes including RAF1 or COT gene over expression, activating mutations in RAS or increased activation of the receptor tyrosine kinase PDGFRβ.
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Impact
GeneRIF
Garraway et al., Cambridge, United States. In Nature, 2011
identification of MAP3K8 (the gene encoding COT/Tpl2) as a MAPK pathway agonist that drives resistance to RAF inhibition in B-RAF(V600E) cell lines
Propagation of human spermatogonial stem cells in vitro.
Impact
van Pelt et al., Amsterdam, Netherlands. In Jama, 2009
To test for the presence of functional spermatogonial stem cells in culture, xenotransplantation to testes of immunodeficient mice was performed, and migrated human spermatogonial stem cells after transplantation were detected by COT-1 fluorescence in situ hybridization.
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
Impact
Ley et al., London, United Kingdom. In Nat Immunol, 2006
The TPL-2 MEK kinase is essential for activation of the Erk MAP kinase pathway during innate immune responses.
TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.
Impact
Ley et al., London, United Kingdom. In Nature, 1999
TPL-2 was originally identified, in a carboxy-terminal-deleted form, as an oncoprotein in rats and is more than 90% identical to the human oncoprotein COT.
The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.
Impact
Greene et al., San Francisco, United States. In Immunity, 1999
The proto-oncogene Cot/Tpl-2 encodes a MAP3K-related serine-threonine kinase.
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