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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cortactin

cortactin, EMS1
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Actin, Src, Arp2, V1a, CAN
Papers using cortactin antibodies
Cortactin in tumor invasiveness
Supplier
Hotchin Neil A., In PLoS ONE, 2007
... Cortactin siRNA (catalog # SI00300160) was purchased from Qiagen.
Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation
Supplier
Katoh Hironori et al., In The Journal of Cell Biology, 2006
... mouse mAbs against Myc (9E10), RhoA (26C4), and Dock4 (R6Y), rabbit pAbs against EphA2 (C-20), cortactin (H-191) and HA (Y-11), and a rat mAb against RhoG (1F3 B3 E5; Santa Cruz Biotechnology, Inc.); mouse mAbs against ...
Proximal, selective, and dynamic interactions between integrin αIIbβ3 and protein tyrosine kinases in living cells
Supplier
Shattil Sanford J. et al., In The Journal of Cell Biology, 2000
... Antibodies to Syk and cortactin were obtained from Santa Cruz Biotechnology, Inc ...
c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process
Supplier
Liao Kan et al., In BMC Cell Biology, 1999
... Anti-cortactin, anti-phosphotyrosine and anti-EGFP antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Distinct ligand binding sites in integrin α3β1 regulate matrix adhesion and cell–cell contact
Supplier
Chapman Harold A. et al., In The Journal of Cell Biology, 1998
... Polyclonal antibodies to cortactin and p130Cas were purchased from Santa Cruz Biotechnology, Inc ...
Papers on cortactin
Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells.
New
Yuan et al., Suihua, China. In Lab Invest, Feb 2016
The roles of pY397 in regulating the activities of Rac1 and cortactin and the invasive properties of OSCC cells were further determined.
Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.
New
Ng et al., Kuala Lumpur, Malaysia. In J Oral Pathol Med, Feb 2016
Cortactin and MMT1-MMP are two invadopodia proteins implicated in its local invasiveness.
Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
New
Impact
Way et al., Gif-sur-Yvette, France. In Nat Cell Biol, Jan 2016
This difference reflects the ability of cortactin to stabilize ARPC1B- and ARPC5L- but not ARPC1A- and ARPC5-containing complexes against coronin-mediated disassembly.
How distinct Arp2/3 complex variants regulate actin filament assembly.
New
Impact
Stradal et al., Braunschweig, Germany. In Nat Cell Biol, Jan 2016
Distinct variants of the Arp2/3 complex are now shown to have different roles in tuning actin assembly and disassembly, in concert with the prominent actin regulators cortactin and coronin.
KISS1R signaling promotes invadopodia formation in human breast cancer cell via β-arrestin2/ERK.
New
Bhattacharya et al., London, Canada. In Cell Signal, Jan 2016
We show for the first time that KISS1R signaling induces invadopodia formation and activation of key invadopodia proteins, cortactin, cofilin and membrane type I matrix metalloproteases (MT1-MMP).
Dynamin is required for GnRH signaling to L-type calcium channels and activation of ERK.
New
Navratil et al., Seattle, United States. In Endocrinology, Jan 2016
Coincident with translocation of dynamin-GFP to the plasma membrane, we demonstrated that dynamin colocalizes with the actin cytoskeleton and the actin binding protein, cortactin at the leading edge of the plasma membrane.
Decreased expression of cortactin in the schizophrenia brain.
New
Meador-Woodruff et al., New York City, United States. In Neuroreport, Jan 2016
To determine whether the Arp2/3 complex is abnormally expressed in schizophrenia, we measured the protein expression of Arp2 and Arp3, as well as Arp2/3 complex binding partners and associated proteins including cortactin, neuronal-Wiskott-Aldrich syndrome protein (WASP), WASP-family verprolin homologous protein 1 (WAVE1), and Abelson interactor 1 (Abi1) in the superior temporal gyrus of paired schizophrenia and comparison participants.
CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia.
New
Impact
Ghysdael et al., Orsay, France. In Cancer Cell, Jul 2015
We further demonstrate that calcineurin regulates CXCR4 cell-surface expression in a cortactin-dependent manner, a mechanism essential to the migratory properties of T-ALL cells.
Targeting Abl kinases to regulate vascular leak during sepsis and acute respiratory distress syndrome.
Review
New
Dudek et al., Amsterdam, Netherlands. In Arterioscler Thromb Vasc Biol, May 2015
The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and β-catenin.
Endothelial actin-binding proteins and actin dynamics in leukocyte transendothelial migration.
Review
New
Schnoor, Mexico. In J Immunol, May 2015
This review focuses on recently published evidence that endothelial ABPs, such as cortactin, myosin, or α-actinin, regulate leukocyte extravasation by controlling actin dynamics, biomechanical properties of endothelia, and signaling pathways, such as GTPase activation, during inflammation.
Cellular protrusions--lamellipodia, filopodia, invadopodia and podosomes--and their roles in progression of orofacial tumours: current understanding.
Review
Siar et al., Kuala Lumpur, Malaysia. In Asian Pac J Cancer Prev, 2014
Invadopodia-associated protein markers consisted of 129 proteins belonging to different functional classes including WASP, NWASP, cortactin, Src kinase, Arp 2/3 complex, MT1-MMP and F-actin.
Podosomes as novel players in endothelial biology.
Review
Primo et al., Torino, Italy. In Eur J Cell Biol, 2014
These specialized micro-domains of the plasma membrane are characterized by enrichment of F-actin, cortactin and metalloproteases.
Intracellular transport based on actin polymerization.
Review
Khaitlina, Saint Petersburg, Russia. In Biochemistry (mosc), 2014
Moreover, the actin-based systems often contain dynamin and cortactin.
A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.
Impact
Hodgson et al., New York City, United States. In Nat Cell Biol, 2014
We describe here an invadopodia disassembly model, where a signalling axis involving TrioGEF, Rac1, Pak1, and phosphorylation of cortactin, causes invadopodia dissolution.
Cortactin and focal adhesion kinase as predictors of cancer risk in patients with premalignant oral epithelial lesions.
GeneRIF
García-Pedrero et al., Oviedo, Spain. In Oral Oncol, 2012
Strong immunoexpression of cortactin is a predicting factor for increased cancer risk in oral premalignant lesions.
Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells.
GeneRIF
Zhao et al., Pittsburgh, United States. In J Biol Chem, 2012
LPS modulation of cortactin stability is coordinately regulated by stress kinases and the ubiquitin-proteasomal network.
β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy.
GeneRIF
Cordes et al., Dresden, Germany. In J Clin Invest, 2012
Dephosphorylation of FAK upon inhibition of beta integrin resulted in dissociation of a FAK/cortactin protein complex. This, in turn, downregulated JNK signaling and induced cell rounding, leading to radiosensitization.
Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading.
GeneRIF
Martinez-Quiles et al., Madrid, Spain. In Plos One, 2011
we demonstrate that cell spreading promotes the association of cortactin and FAK and that tyrosine phosphorylation of cortactin disrupts this interaction, which may explain how it inhibits cell spreading.
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function.
Review
Impact
Courtneidge et al., Los Angeles, United States. In Nat Rev Mol Cell Biol, 2011
The key proteins in these structures include the actin regulators cortactin and neural Wiskott-Aldrich syndrome protein (N-WASP), the adaptor proteins Tyr kinase substrate with four SH3 domains (TKS4) and Tyr kinase substrate with five SH3 domains (TKS5), and the metalloprotease membrane type 1 matrix metalloprotease (MT1MMP; also known as MMP14).
Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival.
GeneRIF
Patiño-García et al., Pamplona, Spain. In Cancer Biomark, 2010
Over-expression of cortactin, contained in the 11q13 amplicon, is involved in osteosarcoma carcinogenesis.
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