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Coronin, actin binding protein, 1C

Coronin 3, coronin-1C, CORO1C
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, Insulin, V1a, CAN, Arp2
Papers on Coronin 3
Proteomic screening and identification of microRNA-128 targets in glioma cells.
Peng et al., Beijing, China. In Proteomics, Aug 2015
A luciferase assay validated that 11 of 13 selected genes were potential targets of miR-128, and a mutagenesis experiment confirmed CBFB, CORO1C, GLTP, HnRNPF, and TROVE2 as the target genes.
Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking.
Bass et al., Sheffield, United Kingdom. In J Biol Chem, Jul 2015
We discover that both coronin-1C and caveolin retrieve Rac1 from similar locations at the rear and sides of the cell.
Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C.
Seki et al., Kagoshima, Japan. In J Hum Genet, Feb 2015
Coronin-1C (CORO1C) was a common target gene of the miR-1/133a cluster, as shown by the genome-wide gene expression analysis and the luciferase reporter assay.
Integration of the Rac1- and actin-binding properties of Coronin-1C.
Bass et al., Bristol, United Kingdom. In Small Gtpases, 2014
We recently reported 2 interactions that were unique to coronin-1C: binding of a Rac1 inhibitor, RCC2, to the unique linker region and Rac1 itself to the propeller domain in a manner that differs from that proposed for other coronins.
miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer.
Williams et al., Houston, United States. In Mol Oncol, 2014
In this study, we show that miR-206 was decreased in TNBC clinical tumor samples and cell lines whereas one of its predicted targets, actin-binding protein CORO1C, was increased.
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.
Bass et al., Bristol, United Kingdom. In J Cell Sci, 2014
Here, we identify interactions between coronin-1C (Coro1C), RCC2 and Rac1 that focus active Rac1 to a single protrusion.
Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C.
Kamata et al., Matsumoto, Japan. In Free Radic Biol Med, 2014
By affinity purification with the substrate-trapping mutant of PTP1B, tyrosine-phosphorylated coronin-1C was identified as a substrate of PTP1B.
Activated Cdc42-bound IQGAP1 determines the cellular endocytic site.
Niki et al., Ōita, Japan. In Mol Cell Biol, 2013
Silencing of IQGAP1 inhibits both endocytosis and the glucose-induced redistribution of endocytic machinery, including Rab27a and its binding protein coronin 3.
CRN2 enhances the invasiveness of glioblastoma cells.
Clemen et al., Hamburg, Germany. In Neuro Oncol, 2013
BACKGROUND: Movement of tumor cells involves dynamic remodeling of the actin cytoskeleton, which is regulated by actin binding proteins, such as CRN2 (synonyms: coronin 1C, coronin 3).
Knockdown of Coronin-1C disrupts Rac1 activation and impairs tumorigenic potential in hepatocellular carcinoma cells.
Fang et al., Changchun, China. In Oncol Rep, 2013
Coronin-1C is an important F-actin binding protein which is critical for cell motility.
Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin.
Bear et al., Chapel Hill, United States. In Biochem J, 2012
Coronin 1C displays highly co-operative binding to actin filaments. We highlight a novel mode of coronin regulation, which has implications for how coronins orchestrate cytoskeletal dynamics.
Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K.
Fan et al., Xi'an, China. In Mol Cancer, 2011
BACKGROUND: Coronins are a family of highly evolutionary conserved proteins reportedly involved in the regulation of actin cytoskeletal dynamics, although only coronin 3 has been shown to be related to cancer cell migration.
Rab27a in pancreatic beta-cells, a busy protein in membrane trafficking.
Niki et al., Ōita, Japan. In Prog Biophys Mol Biol, 2011
We recently found that Rab27a also possesses the GDP-dependent effector coronin 3. Coronin 3 regulates endocytosis in pancreatic beta-cells through its interaction with GDP-Rab27a.
Rab27a, actin and beta-cell endocytosis.
Niki et al., Ōita, Japan. In Endocr J, 2010
Recently, we searched for Rab27a-interacting proteins and identified coronin 3. Unexpectedly, coronin 3 only bound GDP-Rab27a and this interaction regulated post-exocytotic stages via reorganization of the actin cytoskeleton.
Primary effusion lymphoma: genomic profiling revealed amplification of SELPLG and CORO1C encoding for proteins important for cell migration.
Du et al., Cambridge, United Kingdom. In J Pathol, 2010
There is a strong expression of both SELPLG and coronin-1C in the majority of primary effusion lymphomas, irrespective of their gene dosage. SELPLG is critical for cell migration and chemotaxis, while CORO1C regulates actin-dependent processes.
[Increased coronin-1C expression is related to hepatocellular carcinoma invasion and metastasis].
Li et al., Wuhan, China. In Zhonghua Gan Zang Bing Za Zhi, 2010
Patients with higher coronin-1C expression had a more advanced stage of hepatocellular carcinoma.
Glucose-induced translocation of coronin 3 regulates the retrograde transport of the secretory membrane in the pancreatic beta-cells.
Niki et al., Ōita, Japan. In Biochem Biophys Res Commun, 2010
These results indicate that glucose recruits coronin 3 near the plasma membrane, and that it regulates the retrograde transport of the secretory membrane in pancreatic beta-cells.
Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells.
Nusrat et al., Atlanta, United States. In Biochem Biophys Res Commun, 2010
Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion.
The role of mammalian coronins in development and disease.
Bear et al., Chapel Hill, United States. In Subcell Biochem, 2007
This review primarily focuses on Coronin 1C (HGNC symbol: CORO1C, also known as Coronin 3) which is a transcriptionally dynamic gene that is up-regulated in multiple types of clinically aggressive cancer.
Coronin structure and implications.
Hofmann et al., Brisbane, Australia. In Subcell Biochem, 2007
There are indications that this modification regulates the quaternary structure of coronin 3 (1C) and thus has implications for the cellular localisation and the general link between signalling and cytoskeletal remodelling.
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