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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

REST corepressor 1

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Histone, REST, demethylase, CYP3A4, HDAC
Papers using CoREST antibodies
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.
Xu Wenqing, In PLoS ONE, 2005
... The coding regions of CoREST and LSD1 were amplified from human fetal thymus cDNA library (BD Biosciences) and ZNF198 was amplified ...
Papers on CoREST
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.
Lacaud et al., Monterotondo, Italy. In Nat Cell Biol, Jan 2016
Finally, we demonstrate that GFI1 proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST repressive complex, to epigenetically silence the endothelial program in HE and allow the emergence of blood cells.
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation.
Hedrick et al., Los Angeles, United States. In Nat Immunol, Dec 2015
Furthermore, we found that Nr4a1 repressed autocrine NE production in macrophages by recruiting the corepressor CoREST to the Th promoter.
H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.
Salcini et al., Copenhagen, Denmark. In Nucleic Acids Res, Dec 2015
Biochemical analyses indicated that HPL-1 binds to H3K23me2 and interacts with a conserved CoREST repressive complex.
A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity.
McCafferty et al., Durham, United States. In Febs Lett, Sep 2015
This chimera copurifies with FAD and displays demethylase activity, but fails to bind the partner protein corepressor of the RE1-silencing transcription factor (CoREST).
The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB.
Tjalkens et al., College Station, United States. In Mol Pharmacol, Jun 2015
Consistent with these findings, C-DIM12 also stabilized binding of the Corepressor for Repressor Element 1 Silencing Transcription Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2).
Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex.
Tan et al., United States. In Nucleic Acids Res, Jun 2015
The flavin-dependent monoamine oxidase LSD1 (lysine-specific demethylase 1, also known as KDM1) demethylates mono- and dimethylated H3K4 in peptide substrates, but requires the corepressor protein, CoREST, to demethylate nucleosome substrates.
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
Distler et al., Erlangen, Germany. In Nat Med, Feb 2015
NR4A1 recruits a repressor complex comprising SP1, SIN3A, CoREST, LSD1, and HDAC1 to TGF-β target genes, thereby limiting pro-fibrotic TGF-β effects.
Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation.
Andrés et al., Santiago, Chile. In Plos One, 2014
CoREST (CoREST1, rcor1) transcriptional corepressor together with the histone demethylase LSD1 (KDM1A) and the histone deacetylases HDAC1/2 form LSD1-CoREST-HDAC (LCH) transcriptional complexes to regulate gene expression.
Chromatin regulation: how complex does it get?
Brehm et al., Marburg an der Lahn, Germany. In Epigenetics, 2014
In this review we discuss our current knowledge of repressor complexes that contain MBT domain proteins and/or the CoREST co-repressor and use them as a paradigm to illustrate the unexpected heterogeneity and tool sharing of chromatin regulating protein complexes.
Chromatin repressive complexes in stem cells, development, and cancer.
Helin et al., Copenhagen, Denmark. In Cell Stem Cell, 2014
Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer.
HOTAIR: a cancer-related long non-coding RNA.
Zhang et al., In Neoplasma, 2013
Recent studies revealed HOX transcript antisense RNA, a lncRNA with regulatory functions of transcription, could bind PRC2 and LSD1/CoREST/REST complexes and direct to the specific gene sites, resulted in H3K27 methylation and H3K4 demethylation and ultimately gene silencing.
The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts.
Cowley et al., Leicester, United Kingdom. In Biochem Soc Trans, 2013
HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often found together in three major multiprotein co-repressor complexes: Sin3, NuRD (nucleosome remodelling and deacetylation) and CoREST (co-repressor for element-1-silencing transcription factor).
The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency.
Roizman et al., Chicago, United States. In Viruses, 2013
REST is a key component of the HDAC1 or 2, CoREST, LSD1, REST (HCLR) repressor complex.
LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.
Vellore et al., Salt Lake City, United States. In Proc Natl Acad Sci U S A, 2012
the H3 binding pocket is a central target site to (i) switch off LSD1 amino oxidase activity, thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii) prevent chromatin anchoring to LSD1/CoREST.
Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex.
Reyes et al., Sevilla, Spain. In Proc Natl Acad Sci U S A, 2012
Our data uncover a mechanism of regulation of the LSD1-CoREST complex and provide a molecular explanation for the antagonism between Braf35 and iBraf in neuronal differentiation.
RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency.
Gao et al., Beijing, China. In Stem Cells, 2011
Ectopic expression of Rcor2 in both mouse and human somatic cells effectively substituted the requirement for exogenous Sox2 expression in somatic cell reprogramming.
Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.
Mattevi et al., San Diego, United States. In Structure, 2011
Transciption factor SNAIL1 mimics the histone H3 tail and binds to the histone demethylase LSD1-transcription co-repressor (CoREST) complex. The crystal structure of the complex is given here.
The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes.
Roizman et al., Chicago, United States. In Mbio, 2010
The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes.
DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.
Jones et al., Salt Lake City, United States. In Cell, 2010
Apc mutants lack retinoic acid as a result of the transcriptional repression of retinol dehydrogenase l1 via a complex that includes Lef1, Groucho2, Ctbp1, Lsd1, and Corest.
8 Demethylation pathways for histone methyllysine residues.
Battagliol et al., Pavia, Italy. In Enzymes, 2005
LSD1 (previously known as KIAA0601) has been typically found in association with CoREST (a corepressor protein) and histone deacetylases 1 and 2, forming a highly conserved core complex.
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