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COQ3 Coq3p

COQ3, Coq3p, 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, STEP, fibrillin-1, CAN, OUT
Papers on COQ3
Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants.
Clarke et al., Los Angeles, United States. In Biochim Biophys Acta, 2014
The Coq4 polypeptide persists at high molecular mass with over-expression of Coq8 in coq3, coq5, coq6, coq7, coq9, and coq10 mutants, indicating that Coq4 is a central organizer of the Coq complex.
Regulation of coenzyme Q biosynthesis in yeast: a new complex in the block.
Review
Santos-Ocaña et al., Sevilla, Spain. In Iubmb Life, 2014
The phosphorylation of Coq3p and Coq5p by the kinase Coq8p facilitates the formation of an initial precomplex of 700 kDa that contains all Coq proteins with the exception of Coq7p.
Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.
Kawamukai et al., Matsue, Japan. In Plos One, 2013
Here, we expand these findings by identifying ten genes (dps1, dlp1, ppt1, and coq3-9) that are required for CoQ synthesis.
Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues.
GeneRIF
Villalba et al., Córdoba, Spain. In Free Radic Biol Med, 2011
Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues
Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants.
Clarke et al., Los Angeles, United States. In Biochim Biophys Acta, 2011
Coq3p, Coq5p, and Coq7p were phosphorylated in a Coq8p-dependent manner.
Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration.
Barros et al., São Paulo, Brazil. In Biochem Biophys Res Commun, 2010
As shown here, when over-produced in coq mutants, Coq8p counteracts turnover of Coq3p and Coq4p subunits of the Q-biosynthetic complex.
The yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis.
Clarke et al., Los Angeles, United States. In Biochim Biophys Acta, 2009
The coq4-1 yeast mutant retains significant Coq3p O-methyltransferase activity, and mitochondria isolated from coq4-1 and coq4-2 (E(121)K) yeast point mutants contain normal steady state levels of Coq polypeptides, unlike the decreased levels of Coq polypeptides generally found in strains harboring coq gene deletions.
Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p.
GeneRIF
Rödel et al., Dresden, Germany. In Fems Yeast Res, 2008
putative candidate for phosphorylation by Coq8p.
Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.
Kawamukai et al., Matsue, Japan. In Febs J, 2008
To compare these phenotypes with those of other respiration-deficient mutants, we constructed cytochrome c (cyc1) and coq3 deletion mutants.
Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex.
Clarke et al., Los Angeles, United States. In Arch Biochem Biophys, 2007
Here, we show that steady state levels of Coq3, Coq4, Coq6, Coq7 and Coq9 polypeptides in yeast mitochondria are dependent on the expression of each of the other COQ genes.
Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone.
Drahota et al., Czech Republic. In Biochem Biophys Res Commun, 2006
Idebenone and CoQ1 were found to be more efficient in the scavenging activity (IC50: 0.052 and 0.075 microM, respectively) than CoQ3 (IC50: 45.8 microM).
Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.
GeneRIF
Clarke et al., Los Angeles, United States. In J Biol Chem, 2005
study identifies Coq3 peptide and Coq4 peptide as defining members of a Q-biosynthetic Coq polypeptide complex
Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase.
Clarke et al., Los Angeles, United States. In J Biol Chem, 2005
Deletions in any of the COQ genes affect the steady-state expression of Coq3p, Coq4p, and Coq6p.
Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis.
Clarke et al., Los Angeles, United States. In J Biol Chem, 2004
Two other polypeptides required for Q biosynthesis, Coq3p and Coq4p, are detected in the wild type parent and in the coq5-2 and coq5-5 mutants, but are not detected in the coq5-null mutant, or in the coq5-4 or coq5-3 mutants.
Analysis of respiratory mutants reveals new aspects of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p.
Roach et al., Indianapolis, United States. In Febs Lett, 2002
Respiratory-deficient strains, such as coq3 mutants, have reduced glycogen stores and contain hyperphosphorylated and inactive glycogen synthase.
Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.
Clarke et al., Los Angeles, United States. In J Biol Chem, 2000
The COQ3 gene in Saccharomyces cerevisiae encodes an O-methyltransferase required for two steps in the biosynthetic pathway of ubiquinone (coenzyme Q, or Q).
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