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Ring finger and WD repeat domain 2

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Ubiquitin, ARF1, V1a, p16
Papers using COPI antibodies
Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells
Lupashin Vladimir V. et al., In The Journal of Cell Biology, 2001
... Hay, University of Michigan, Ann Arbor, MI), anti–β-COPI (Sigma-Aldrich), anti-VSVG tag (E11; Delta Biolabs); murine mAbs: anti-GPP130 (A1-118; ...
Papers on COPI
High expression of constitutive photomorphogenic 1 (COP1) is associated with poor prognosis in bladder cancer.
Kuang et al., Nanchang, China. In Tumour Biol, Feb 2016
UNASSIGNED: The present study was to investigate the expression and prognostic value of constitutive photomorphogenic 1 (COP1) in bladder cancer.
Small GTPases in peroxisome dynamics.
Peränen et al., Heidelberg, Germany. In Biochim Biophys Acta, Feb 2016
In vitro-binding assays localized Arf1 and the COPI complex to peroxisomes.
A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1.
Schwappach et al., Göttingen, Germany. In J Cell Sci, Feb 2016
The current model proposes that phosphorylation-dependent binding of 14-3-3 sterically masks a COPI binding motif.
Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation.
Sztul et al., Birmingham, United States. In Am J Physiol Cell Physiol, Jan 2016
The 91/130 mutant appears active as it integrates within the functional network at the Golgi, supports Arf activation and COPI recruitment, and sustains Golgi homeostasis and cargo secretion when provided as a sole copy of functional GBF1 in cells.
Seedlings Transduce the Depth and Mechanical Pressure of Covering Soil Using COP1 and Ethylene to Regulate EBF1/EBF2 for Soil Emergence.
Zhong et al., Beijing, China. In Curr Biol, Jan 2016
Here, we report that constitutive photomorphogenesis 1 (COP1), a central repressor of light signaling, is a key component required for seedlings to sense the depth of soil overlay.
Expression and regulation of COP1 in chronic lymphocytic leukemia cells for promotion of cell proliferation and tumorigenicity.
Xu et al., Xuzhou, China. In Oncol Rep, Jan 2016
The constitutively photomorphogenic 1 (COP1), as an E3 ubiquitin ligase, is involved in many biological processes in mammalian cells, but its role in chronic lymphocytic leukemia (CLL) progression remains unclear.
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
Dixit et al., San Francisco, United States. In Cell, Jan 2016
Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
Illuminating Progress in Phytochrome-Mediated Light Signaling Pathways.
Huq et al., Austin, United States. In Trends Plant Sci, Oct 2015
These include the identification of E3 ligases that degrade PHYTOCHROME INTERACTING FACTOR (PIF) proteins, key negative regulators, in response to light, a better view of how phytochromes inhibit another key negative regulator, CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), and an understanding of why plants evolved multiple negative regulators to repress photomorphogenesis in darkness.
VESICULAR TRANSPORT. A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly.
Briggs et al., Heidelberg, Germany. In Science, Aug 2015
We combined cryo-electron tomography, subtomogram averaging, and cross-linking mass spectrometry to derive a complete model of the assembled coat protein complex I (COPI) coat involved in traffic between the Golgi and the endoplasmic reticulum.
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
Shum et al., Houston, United States. In Nat Genet, Jun 2015
Hypothesizing that mutant COPA leads to defective intracellular transport via coat protein complex I (COPI), we show that COPA variants impair binding to proteins targeted for retrograde Golgi-to-ER transport.
Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42.
Hsu et al., Boston, United States. In Nature, Jun 2015
Here we show that the coat protein I (COPI) complex sorts anterograde cargoes into these tubules in human cells.
The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3.
Daut et al., Göttingen, Germany. In Pflugers Arch, May 2015
The intracellular transport of membrane proteins is controlled by trafficking signals: Short peptide motifs that mediate the contact with COPI, COPII or various clathrin-associated coat proteins.
Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles.
Rabouille et al., Marseille, France. In Front Neurosci, 2014
This is due to down-regulation of COPI coat components, dispersion of Golgi tethers and strong accumulation of ER-Golgi SNAREs.
Light signaling induces anthocyanin biosynthesis via AN3 mediated COP1 expression.
Liu et al., Kunming, China. In Plant Signal Behav, 2014
Here, we briefly review the recent progress on the light-triggered anthocyanin biosynthesis via ANGUSTIFOLIA3 (AN3) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) network in Arabidopsis.
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.
Kaelin et al., Boston, United States. In Cancer Cell, 2014
We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein, which is an ubiquitin ligase component, leading to their destruction.
COP1 mediates the coordination of root and shoot growth by light through modulation of PIN1- and PIN2-dependent auxin transport in Arabidopsis.
Xu et al., Lyon, France. In Development, 2012
COP1 mediates the coordination of root and shoot growth by light through modulation of PIN1- and PIN2-dependent auxin transport in Arabidopsis
Functional annotation of the human fat cell secretome.
Arner et al., Huddinge, Sweden. In Arch Physiol Biochem, 2012
WISP2 gene expression is regulated both by obesity and by the region between visceral and subcutaneous adipose tissue.
Arabidopsis STO/BBX24 negatively regulates UV-B signaling by interacting with COP1 and repressing HY5 transcriptional activity.
Li et al., Guangzhou, China. In Cell Res, 2012
COP1 interacts with BBX24 in vivo in a UV-B-dependent manner, and this requires UV-B-induced COP1 accumulation.
Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1α-TWIST signaling networks in human breast cancer cells.
Banerjee et al., Kansas City, United States. In J Biol Chem, 2012
Studies suggest a novel regulatory pathway exists through which CCN5 exerts its anti-invasive function.
Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling.
Furukawa et al., Nagoya, Japan. In Biochem Biophys Res Commun, 2011
These results suggested that secreted Wisp2/CCN5 induces Akt and ERK phosphorylation via integrins, and consequently facilitates neurite formation and conferred resistance to apoptosis.
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