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Coatomer protein complex, subunit gamma 2

COPG2, gamma2-COP
Top mentioned proteins: COPI, HAD, Igf2r, ACID, Insulin-Like Growth Factor II
Papers on COPG2
Scyl1 scaffolds class II Arfs to specific subcomplexes of coatomer through the γ-COP appendage domain.
McPherson et al., Montréal, Canada. In J Cell Sci, 2014
We now demonstrate that Scy1-like protein 1 (Scyl1), a member of the Scy1-like family of catalytically inactive protein kinases, oligomerizes through centrally located HEAT repeats and uses a C-terminal RKXX-COO(-) motif to interact directly with the appendage domain of coatomer subunit γ-2 (also known as COPG2 or γ2-COP).
High-throughput sequencing analysis of the chromosome 7q32 deletion reveals IRF5 as a potential tumour suppressor in splenic marginal-zone lymphoma.
Martinez-Climent et al., Pamplona, Spain. In Br J Haematol, 2012
spanning a region between the SND1 and COPG2 genes.
Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.
Jirtle et al., Durham, United States. In Bmc Genomics, 2011
In contrast, IMPACT, COPG2, and PLAGL1 were not imprinted in the opossum.
Methylation and expression analyses of the 7q autism susceptibility locus genes MEST , COPG2, and TSGA14 in human and anthropoid primate cortices.
GeneRIF
Haaf et al., Würzburg, Germany. In Cytogenet Genome Res, 2011
In cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes.
Epigenetic states and expression of imprinted genes in human embryonic stem cells.
Singh et al., Kao-hsiung, Taiwan. In World J Stem Cells, 2010
The expression levels of other 21 imprinted genes were relatively low in undifferentiated hESC lines and five of these genes (TP73, COPG2, OSBPL5, IGF2 and ATP10A) were found to be up-regulated in differentiated tissues.
Characterization of conserved and nonconserved imprinted genes in swine.
Piedrahita et al., Raleigh, United States. In Biol Reprod, 2009
Using Affymetrix Porcine GeneChip microarrays and/or semiquantitative PCR, brain, fibroblast, liver, and placenta of Day 30 fetuses were profiled, and 25 imprinted genes were identified as differentially expressed in at least one of the four tissue types: AMPD3, CDKN1C, COPG2, DHCR7, DIRAS3, IGF2 (isoform specific), IGF2AS, IGF2R, MEG3, MEST, NAP1L5, NDN, NNAT, OSBPL1A, PEG3, APEG3, PEG10, PLAGL1, PON2, PPP1R9A, SGCE, SLC38A4, SNORD107, SNRPN, and TFPI2.
Differential localization of coatomer complex isoforms within the Golgi apparatus.
Wieland et al., Heidelberg, Germany. In Proc Natl Acad Sci U S A, 2007
Higher eukaryotes have two paralogous versions of the gamma- and zeta- subunits, termed gamma1- and gamma2-COP and zeta1- and zeta2-COP.
Structure and expression of the zebrafish mest gene, an ortholog of mammalian imprinted gene PEG1/MEST.
Chung et al., Taejŏn, South Korea. In Biochim Biophys Acta, 2005
Zebrafish mest is present as a single copy in the zebrafish genome and is closely linked to copg2 as in mammals.
The COPG2, DCN, and SDHD genes are biallelically expressed in cattle.
Khatib, Madison, United States. In Mamm Genome, 2005
To study the imprinting status of cattle genes and assess their conservation among mammalian species, the expression patterns of COPG2, DCN, and SDHD genes were examined in a total of 128 fetal and adult tissues.
Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.
Kishino et al., Sapporo, Japan. In Genomics, 2004
This region has been suggested to form an imprinted gene cluster, because MEST and its three flanking genes/transcripts (MESTIT1, CPA4, and COPG2IT1) were reported to be imprinted, although two (TSGA14 and COPG2) were shown to escape imprinting.
The gene TSGA14, adjacent to the imprinted gene MEST, escapes genomic imprinting.
Kishino et al., Nagasaki, Japan. In Gene, 2002
The fact that COPG2 and TSGA14, both neighbors of MEST, escape genomic imprinting suggests that the 7q32 imprinted region may be small and not similar to other imprinted domains, such as those at 15q11-13 and 11p15.5.
Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.
GeneRIF
International Molecular Genetic Study of Autism Consortium (IMGSAC) et al., Oxford, United Kingdom. In Mol Psychiatry, 2001
Mutation sscreening and imprinting analysis of candidate genes for autism in the 7q32 region
A narrow segment of maternal uniparental disomy of chromosome 7q31-qter in Silver-Russell syndrome delimits a candidate gene region.
Kere et al., Helsinki, Finland. In Am J Hum Genet, 2001
To date, three imprinted genes-PEG1/MEST, gamma2-COP, and GRB10-have been identified on chromosome 7, but their role in the etiology of SRS remains uncertain.
Identification and characterization of novel isoforms of COP I subunits.
Nakayama et al., Tsukuba, Japan. In J Biochem, 2000
In the present study, we identified homologs of gamma-COP (gamma2-COP; original gamma-COP is referred to as gamma1-COP in this paper) and of zeta-COP (zeta2-COP; original zeta-COP is referred to as zeta1-COP).
Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).
GeneRIF
Chung et al., Taejŏn, South Korea. In Febs Lett, 2000
Copg2 gene, closely linked to Mest/Peg1 gene on chr 6, is paternally imprinted.
Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis.
Kalscheuer et al., Nijmegen, Netherlands. In Chromosome Res, 1999
Sequence analysis revealed the presence of MEST and three additional genes which show homology to plant DNBP (DNA-Binding Protein), vertebrate COPG2 (Coat Protein Gamma 2), as well as to human and mouse UCN (Urocortin).
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