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Coatomer protein complex, subunit alpha

CopA, incA, alpha-COP, Xenin
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, CAN, ACID, HAD, beta-COP
Papers using CopA antibodies
Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI).
Supplier
Valdivia Raphael H., In PLoS ONE, 1996
... IncA1∼22̃ into the pIRES2-EGFP vector (Clontech) using the oligonucleotides FO134 ...
Papers on CopA
Real-time PCR based analysis of metal resistance genes in metal resistant Pseudomonas aeruginosa strain J007.
New
Sar et al., Kharagpur, India. In J Basic Microbiol, Jan 2016
The bacterium showed MIC (minimum inhibitory concentration) values of 6, 3, and 2 mM for Zn, Cu, and Cd, respectively; with resistance phenotype conferred by periplasmic Cu sequestering copA and RND type heavy metal efflux czcA genes.
Cytoplasmic CopZ-like, periplasmic Rusticyanin and AcoP proteins are possible new copper resistance determinants in Acidithiobacillus ferrooxidans ATCC 23270.
New
Jerez et al., Santiago, Chile. In Appl Environ Microbiol, Jan 2016
It contains canonical copper resistance determinants present in other bacteria such as CopA ATPases and RND efflux pumps but these components do not entirely explain its high metal tolerance.
The Proteome of Primary Prostate Cancer.
New
Flores-Morales et al., Copenhagen, Denmark. In Eur Urol, Jan 2016
Molecular analysis indicated that some of the proteins overexpressed in tumors, such as carnitine palmitoyltransferase 2 (CPT2, fatty acid transporter), coatomer protein complex, subunit alpha (COPA, vesicle secretion), and mitogen- and stress-activated protein kinase 1 and 2 (MSK1/2, protein kinase) regulate the proliferation of PCa cells.
Newly recognized Mendelian disorders with rheumatic manifestations.
Review
New
Goldbach-Mansky et al., Bethesda, United States. In Curr Opin Rheumatol, Sep 2015
Mutations in ADA2, TRNT1 and COPA, AP1S3, and TNFRSF11A cause complex syndromes; loss-of-function mutations in enzymes and molecules are linked to the generation of 'cellular stress' and the release of inflammatory mediators that likely cause the inflammatory disease manifestations.
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
New
Impact
Shum et al., Houston, United States. In Nat Genet, Jun 2015
We identified four unique deleterious variants in the COPA gene (encoding coatomer subunit α) affecting the same functional domain.
Plasmids in the driving seat: The regulatory RNA Rcd gives plasmid ColE1 control over division and growth of its E. coli host.
Review
New
Summers et al., Cambridge, United Kingdom. In Plasmid, Mar 2015
Non-coding RNAs, such as CopA and Sok from plasmid R1, or RNAI from ColE1, exerted regulation by refolding the secondary structures of their target RNAs or modifying their translation.
Prevalence of extended-spectrum cephalosporin-resistant Escherichia coli in a farrowing farm: ST1121 clone harboring IncHI2 plasmid contributes to the dissemination of bla CMY-2.
Liao et al., Guangzhou, China. In Front Microbiol, 2014
Complete sequence analysis of this IncHI2 plasmid (pEC5207) revealed that pEC5207 may have originated through recombination of an IncHI2 plasmid with a bla CMY-2-carrying IncA/C plasmid like pCFSAN007427_01.
Insight into the mobilome of Aeromonas strains.
Review
Popowska et al., Warsaw, Poland. In Front Microbiol, 2014
This review discusses the recently published information on MGE prevalent in Aeromonas spp. with special emphasis on plasmids belonging to different incompatibility groups, i.e., IncA/C, IncU, IncQ, IncF, IncI, and ColE-type.
The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids.
Review
Burrus et al., Sherbrooke, Canada. In Front Microbiol, 2014
Integrative and conjugative elements (ICEs) of the SXT/R391 family (SRIs) and IncA/C conjugative plasmids (ACPs) are responsible for the dissemination of a broad spectrum of antibiotic resistance genes among diverse species of Enterobacteriaceae and Vibrionaceae.
Escherichia coli under Ionic Silver Stress: An Integrative Approach to Explore Transcriptional, Physiological and Biochemical Responses.
Girbal et al., Toulouse, France. In Plos One, 2014
copA, cueO, mgtA, nhaR) and for coping with various types of stress (dnaK, pspA, metA,R, oxidoreductase genes).
RNA editome imbalance in hepatocellular carcinoma.
Review
Chen et al., Singapore, Singapore. In Cancer Res, 2014
In particular, hepatocellular carcinoma editome is severely disrupted and characterized by hyper- and hypoediting of different genes, such as hyperedited AZIN1 (antizyme inhibitor 1) and FLNB (filamin B, β) and hypoedited COPA (coatomer protein complex, subunit α).
Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.
GeneRIF
Marsh et al., Little Rock, United States. In Traffic, 2012
Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number
A biomimetic polyketide-inspired approach to small-molecule ligand discovery.
Impact
Micalizio et al., Jupiter, United States. In Nat Chem, 2012
A novel class of chiral and conformationally constrained oligomers is described (termed 'chiral oligomers of pentenoic amides', COPA), which offers compatibility with split-and-pool methods and can be screened en masse in a batch mode.
Crystal structure of a copper-transporting PIB-type ATPase.
Impact
Nissen et al., Århus, Denmark. In Nature, 2011
Here we present the structure of a PIB-ATPase, a Legionella pneumophila CopA Cu(+)-ATPase, in a copper-free form, as determined by X-ray crystallography at 3.2 Å resolution.
The COPI vesicle complex binds and moves with survival motor neuron within axons.
GeneRIF
Androphy et al., Worcester, United States. In Hum Mol Genet, 2011
SMN directly binds to COPI and moves with survival motor neuron within axons.
Knockdown of COPA, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model.
GeneRIF
Saga et al., Chiba, Japan. In Genomics, 2010
In a a large-scale functional screening of mesothelioma cells, the COPA protein was highly expressed in some mesothelioma cell lines but not in a pleural mesothelial cell line.
Yip1A regulates the COPI-independent retrograde transport from the Golgi complex to the ER.
GeneRIF
Murata et al., Tokyo, Japan. In J Cell Sci, 2009
These results suggested that Yip1A has a role in COPI-independent retrograde transport from the Golgi to the ER and regulates the membrane recruitment of Rab6.
The role of SPINK1 in ETS rearrangement-negative prostate cancers.
Impact
Chinnaiyan et al., Ann Arbor, United States. In Cancer Cell, 2008
Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases).
Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.
GeneRIF
Johnson et al., Hong Kong, Hong Kong. In J Hepatol, 2003
Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues.
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.
Impact
Cosson et al., Basel, Switzerland. In Cell, 1995
Coatomer from beta'-COP (sec27-1) and alpha-COP (ret1-1) mutants, but not from gamma-COP (sec21) mutants, had lost the ability to bind dilysine motifs in vitro.
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