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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Contactin 1

contactin, gp135, F-3
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CD45, CAN, HAD, ACID, Neurofascin
Papers on contactin
Caspr Controls the Temporal Specification of Neural Progenitor Cells through Notch Signaling in the Developing Mouse Cerebral Cortex.
New
Ma et al., Suzhou, China. In Cereb Cortex, Feb 2016
In this study, we show that the adhesion molecule contactin-associated protein (Caspr), which is involved in the maintenance of the polarized domains of myelinated axons, is essential for the timing of generation of neurons and astrocytes in the developing mouse cerebral cortex.
Neuronal autoantibodies in epilepsy patients with peri-ictal autonomic findings.
New
Baykan et al., İstanbul, Turkey. In J Neurol, Feb 2016
Among seropositive patients, antibodies were directed against N-methyl-D-aspartate receptor (NMDAR) in 5 (29 %), contactin-associated protein-like 2 (CASPR2) in 5 (29 %), uncharacterized voltage gated potassium channel (VGKC)-complex antigens in 3 (18 %), glutamic acid decarboxylase (GAD) in 2 (12 %), glycine receptor (GLYR) in one (6 %) and type A gamma aminobutyric acid receptor (GABAAR) in one patient (6 %).
RACK1 affects glioma cell growth and differentiation through the CNTN2-mediated RTK/Ras/MAPK pathway.
New
Jiang et al., Changsha, China. In Int J Mol Med, Jan 2016
Receptor for activated C kinase 1 (RACK1) and contactin-2 (CNTN2) are known to be abnormally expressed in gliomas; however, the association between RACK1 and CNTN2, and the effects of RACK1 and CNTN2 on glioma cell differentiation and the related molecular mechanisms remain largely unknown.
Structural characterization of the extracellular domain of CASPR2 and insights into its association with the novel ligand Contactin1.
New
Comoletti et al., United States. In J Biol Chem, Jan 2016
Using a combination of biophysical techniques, including small angle X-ray scattering, single particle EM, analytical ultracentrifugation and bio-layer interferometry, we present novel structural and functional data that relate the architecture of the extracellular domain of CASPR2 to a previously unknown ligand, Contactin 1 (CNTN1).
Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus.
New
Kim et al., New Haven, United States. In J Comp Neurol, Jan 2016
Our analysis revealed 12 molecules with distinct expression patterns in mouse sSC: cadherin 7, contactin 3, netrin G2, cadherin 6, protocadherin 20, retinoid-related orphan receptor β, brain-specific homeobox/POU domain protein 3b, Ets variant gene 1, substance P, somatostatin, vasoactive intestinal polypeptide and parvalbumin.
Imaging of autoimmune encephalitis - Relevance for clinical practice and hippocampal function.
Review
New
Finke et al., Berlin, Germany. In Neuroscience, Dec 2015
Here, we review the neuroimaging characteristics of autoimmune encephalitides, including N-methyl-d-aspartate (NMDA) receptor, leucine-rich glioma inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2) encephalitis as well as more recently discovered and less frequent forms such as dipeptidyl-peptidase-like protein 6 (DPPX) or glycine receptor encephalitis.
Paranodal and other autoantibodies in chronic inflammatory neuropathies.
Review
New
Illa et al., Madrid, Spain. In Curr Opin Neurol, Oct 2015
Antibodies of the IgG4 isotype targeting the paranodal proteins contactin-1 (CNTN1) and neurofascin-155 (NF155) define specific CIDP subtypes and have diagnostic and prognostic implications.
Rasmussen Syndrome and Other Inflammatory Epilepsies.
Review
New
Cross et al., London, United Kingdom. In Semin Neurol, Jun 2015
Extracellular antibodies are directed at cell-surface-expressed neuronal or glial proteins: glutamate receptors (N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazol-propionic acid), voltage-gated potassium channel complex (contactin-associated-protein 2 [CASPR2], contactin-2 and leucin-rich, glioma-inactivated 1 [LGI1]), and γ-aminobutyric acid (GABA) receptors (GABABR and GABAAR).
Connecting the CNTNAP2 Networks with Neurodevelopmental Disorders.
Review
New
Poot, Utrecht, Netherlands. In Mol Syndromol, Feb 2015
Based on genomic rearrangements and copy number variations, the contactin-associated protein-like 2 gene (CNTNAP2) has been implicated in neurodevelopmental disorders such as Gilles de la Tourette syndrome, intellectual disability, obsessive compulsive disorder, cortical dysplasia-focal epilepsy syndrome, autism, schizophrenia, Pitt-Hopkins syndrome, and attention deficit hyperactivity disorder.
Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons.
Review
Bao, Shanghai, China. In Mol Pain, 2014
Axonal transport and localization of Navs in afferent fibers involves the motor protein KIF5B and scaffold proteins, including contactin and PDZ domain containing 2. Localization of Nav1.6 to the nodes of Ranvier in myelinated fibers of primary sensory neurons requires node formation and the submembrane cytoskeletal protein complex.
Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.
Impact
Fishell et al., In Nature, 2014
Using a microarray screen that focused upon synapse-associated molecules, we identified Cntnap4 (contactin associated protein-like 4, also known as Caspr4) as highly enriched in developing murine interneurons.
Contactin 1 (CNTN1) expression associates with regional lymph node metastasis and is a novel predictor of prognosis in patients with oral squamous cell carcinoma.
GeneRIF
Guo et al., Shanghai, China. In Mol Med Report, 2012
A high expression of CNTN1 was markedly associated with the regional lymph node metastasis of patients with oral squamous cell carcinoma.
Significance of F3/Contactin gene expression in cerebral cortex and nigrostriatal development.
GeneRIF
Gennarini et al., Bari, Italy. In Mol Cell Neurosci, 2012
In developing cerebral cortex and basal ganglia the F3/Contactin gene is mostly activated during early commitment of neuronal precursors.
Contactin-1 (CNTN-1) overexpression is correlated with advanced clinical stage and lymph node metastasis in oesophageal squamous cell carcinomas.
GeneRIF
Zhang et al., Jiangyin, China. In Jpn J Clin Oncol, 2012
The expression of CNTN-1 is upregulated in esophageal squamous cell carcinoma tissue and is related to stage and lymphatic invasion. Thus, it may be involved in the pathogenesis & progression of esophageal squamous cell carcinoma.
A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctions.
GeneRIF
Bhat et al., Chapel Hill, United States. In Plos One, 2010
The first Laminin G-EGF-Laminin G module in the extracellular region of Neurexin IV is necessary for the localization of and association with Contactin.
A spontaneous mutation in contactin 1 in the mouse.
GeneRIF
Burgess et al., Bar Harbor, United States. In Plos One, 2010
The phenotype of the Cntn1 mice arises from dysfunction in the brain, spinal cord or peripheral nervous system.
Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2.
Impact
Morton et al., United States. In N Engl J Med, 2006
Contactin-associated protein-like 2 (CASPR2) is encoded by CNTNAP2 and clusters voltage-gated potassium channels (K(v)1.1)
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells.
Impact
Kuo et al., Taipei, Taiwan. In Cancer Cell, 2006
VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway.
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
Impact
GeneRIF
Xiao et al., Singapore, Singapore. In Cell, 2003
F3 acts as a functional ligand for Notch during oligodendrocyte maturation.
Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif.
Impact
Catterall et al., Seattle, United States. In Cell, 1995
cDNA cloning and sequencing showed that the beta 2 subunit is a 186 residue glycoprotein with an extracellular NH2-terminal domain containing an immunoglobulin-like fold with similarity to the neural cell adhesion molecule (CAM) contactin, a single transmembrane segment, and a small intracellular domain.
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