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Gap junction protein, alpha 1, 43kDa

Connexin 43, Cx43
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GAP, CAN, V1a, ACID, HAD
Papers using Connexin 43 antibodies
Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles.
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Beier Frank, In PLoS ONE, 2006
... To test the specificity of Cx43 ablation, DNA was isolated from bladder, brain, calvaria, heart, humerus, intestine, liver, muscle, skin, and spleen using a Qiagen DNeasy Tissue Kit (Qiagen) ...
Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC
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Lampe Paul D. et al., In The Journal of Cell Biology, 2005
... We made a rabbit anti-pS365-Cx43 antibody by custom commercial preparation (ProSci, Inc.; 13-wk schedule) against ...
Gap junction synthesis and degradation as therapeutic targets. Curr Drug Targets
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Chen Xiongwen, In PLoS ONE, 2001
... Cx43 was over-expressed using Sf9 cells (Life Technologies) and the InsectDirect system ...
Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis
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Bronner-Fraser Marianne, In PLoS Biology, 2000
... mutant mice and CMV-Cx43 transgenic mice have been described ...
Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3
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Furth Emma E. et al., In Gastroenterology Research and Practice, 1998
... Connexin43 immunohistochemical stains were performed with a polyclonal goat connexin43 antibody (clone CXN-6, Santa Cruz Biotechnology) with 1 : 200 dilution and ...
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Papers on Connexin 43
Blood-testis barrier and Sertoli cell function: lessons from SCCx43KO mice.
Review
New
Brehm et al., Hannover, Germany. In Reproduction, Feb 2016
The gap junction protein connexin43 (CX43) plays a vital role in mammalian spermatogenesis by allowing for direct cytoplasmic communication between neighbouring testicular cells.
TLR-Activated Gap Junction Channels Protect Mice against Bacterial Infection through Extracellular UDP Release.
New
Du et al., Shanghai, China. In J Immunol, Feb 2016
Then, connexin 43, as one of the gap junction proteins, was found to be clearly increased by LPS in a dose- and time-dependent manner.
Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.
New
Dai et al., Nanjing, China. In Acta Pharmacol Sin, Feb 2016
Serum hormone levels were measured, and the expression of endothelin receptor A (ETA), connexin 43 (Cx43) and other proteins in testes was detected.
Connexin channels in congenital skin disorders.
Review
New
White et al., New Haven, United States. In Semin Cell Dev Biol, Feb 2016
In palmoplantar keratoderma with deafness, the connexin 26 mutations transdominantly alter the function of wild-type connexin 43 and create leaky heteromeric hemichannels.
Pannexin 3 and connexin 43 modulate skeletal development via distinct functions and expression patterns.
New
Yamada et al., Bethesda, United States. In J Cell Sci, Feb 2016
UNASSIGNED: Pannexin 3 (Panx3) and connexin 43 (Cx43) are two major gap junction proteins expressed in osteoblasts.
Roles of connexins in testis development and spermatogenesis.
Review
New
Cyr et al., London, Canada. In Semin Cell Dev Biol, Feb 2016
Intercellular communication, particularly via connexin43 (Cx43) gap junctions, plays a critical role in the development of germ cells during fetal development and during spermatogenesis in the adult.
Connexins in The Skeleton.
Review
New
Civitelli et al., Saint Louis, United States. In Semin Cell Dev Biol, Jan 2016
The gap junction protein connexin43 (Cx43) has emerged as a key modulator of skeletal growth and homeostasis.
Common mechanisms linking connexin43 to neural progenitor cell migration and glioma invasion.
Review
New
Sin et al., Vancouver, Canada. In Semin Cell Dev Biol, Jan 2016
Recent findings have shown that gap junctions, and specifically connexin43 (Cx43), can play a significant role in these processes, impacting adhesion and cytoskeletal rearrangements.
Differentiation of Human Induced-Pluripotent Stem Cells into Smooth-Muscle Cells: Two Novel Protocols.
New
Zhang et al., Birmingham, United States. In Plos One, Dec 2015
Assessments of cellular mRNA and/or protein levels indicated that SMA, myosin heavy chain II, collagen 1, calponin, transgelin, connexin 43, and vimentin expression in the SMCs obtained via the Contractile SMC protocol and in SMCs differentiated via a traditional protocol were similar, while SMCs produced via the Sythetic SMC protocol expressed less calponin, more collagen 1, and more connexin 43.
Antidepressants Impact Connexin 43 Channel Functions in Astrocytes.
Giaume et al., France. In Front Cell Neurosci, 2014
Moreover, changes in the expression level of the astroglial connexin 43 (Cx43) have been reported in a depressive context.
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Impact
Bhattacharya et al., New York City, United States. In Nature, 2014
Here, using real-time alveolar imaging in situ, we show that a subset of AMs attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with the epithelium.
Connexin 43 phosphorylation and degradation are required for adipogenesis.
GeneRIF
Zahradka et al., Winnipeg, Canada. In Biochim Biophys Acta, 2012
Transient activation of Cx43 via phosphorylation followed by its degradation is vital for preadipocyte differentiation and maturation of functional adipocytes.
A functional interaction between the MAGUK protein hDlg and the gap junction protein connexin 43 in cervical tumour cells.
GeneRIF
Graham et al., Glasgow, United Kingdom. In Biochem J, 2012
Dlg is a physiologically relevant regulator of Cx43 in transformed epithelial cells.
The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation.
GeneRIF
Laird et al., London, Canada. In Exp Dermatol, 2012
During wound healing, mutant Cx43 may enhance keratinocyte proliferation and promote early differentiation of keratinocytes.
MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation.
GeneRIF
Isakson et al., Charlottesville, United States. In Circ Res, 2012
MAP kinase-phosphorylated connexin43 is a novel interacting partner of cyclin E in vascular smooth muscle cells (VSMC) via a novel interaction that is critical for VSMC proliferation and may be important in the development of atherosclerotic lesions.
Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury.
Impact
Bhattacharya et al., New York City, United States. In Nat Med, 2012
Live optical studies revealed that the mBMSCs formed connexin 43 (Cx43)-containing gap junctional channels (GJCs) with the alveolar epithelia in these mice, releasing mitochondria-containing microvesicles that the epithelia engulfed.
Intercellular calcium waves in primary cultured rat mesenteric smooth muscle cells are mediated by connexin43.
GeneRIF
Meister et al., Lausanne, Switzerland. In Cell Commun Adhes, 2012
Cx43 forms the functional gap junctions that are involved in mediating intercellular calcium waves.
Astroglial metabolic networks sustain hippocampal synaptic transmission.
Impact
GeneRIF
Giaume et al., Paris, France. In Science, 2009
study shows connexins 43 & 30 allow intercellular trafficking of glucose & its metabolites through astroglial networks
RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression.
Impact
Mahadevan et al., Charlottesville, United States. In Nat Genet, 2008
Transgene expression resulted in cardiac conduction defects, increased expression of the cardiac-specific transcription factor NKX2-5 and profound disturbances in connexin 40 and connexin 43.
Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia.
Impact
Fleischmann et al., Bonn, Germany. In Nature, 2008
VT protection is critically dependent on expression of the gap-junction protein connexin 43 (Cx43; also known as Gja1): SMs genetically engineered to express Cx43 conferred a similar protection to that of eCMs against induced VT.
More papers using Connexin 43 antibodies
Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis
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Lo C.W. et al., In The Journal of Cell Biology, 1991
... For CMV43, a transgenic mouse line in which Cx43 is overexpressed in neural crest cells, both hemizygous and homozygous embryos could be obtained since these transgenic mice are homozygous viable ...
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