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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Connective tissue growth factor

connective tissue growth factor, CTGF, CCN2
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: V1a, CAN, Actin, fibronectin, HAD
Papers using connective tissue growth factor antibodies
The anti-proliferative effect of rosiglitazone on angiotensin II-induced vascular smooth muscle cell proliferation is mediated by the mTOR pathway
Supplier
Niu Xiaolin et al., In PPAR Research, 2011
... Polyclonal anti-rat CTGF and TGF-β antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Supplier
Silver Richard M. et al., In Pulmonary Medicine, 2010
... Anti-CTGF antibody and anti-Met (C-12) antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, Calif) ...
Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications.
Supplier
Das Hiranmoy, In PLoS ONE, 2009
... type I and collagen type III from Rockland Immunochemicals, (Gilbertsville, PA, USA); connective tissue growth factor (CTGF) from Abcam Inc ...
Brain renin-angiotensin system - focus on transgenic animal models.
Supplier
Nogales-Gadea Gisela, In PLoS ONE, 2005
... Generation of CTGF-transgenic mice (CTGF-TG) ...
Retinal vessel centerline extraction using multiscale matched filters, confidence and edge measures.
Supplier
Ho Paulo Lee, In PLoS ONE, 2005
... (Frankfurt am Main, Germany), antibodies against glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (V-18) and connective tissue growth factor (CTGF) (L-20) were from Santa Cruz Biotechnology (Heidelberg, Germany), the total ...
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Papers on connective tissue growth factor
Reduction of fibroblast size/mechanical force down-regulates TGF-β type II receptor: implications for human skin aging.
New
Quan et al., Ann Arbor, United States. In Aging Cell, Feb 2016
Down-regulation of TβRII was associated with significantly decreased phosphorylation, DNA-binding, and transcriptional activity of its key downstream effector Smad3 and reduced expression of Smad3-regulated essential ECM components type I collagen, fibronectin, and connective tissue growth factor (CTGF/CCN2).
Hydroxysafflor Yellow A Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice.
New
Tan et al., Beijing, China. In Phytother Res, Feb 2016
mRNA expression of transforming growth factor-β1 (TGF-β1), connective tissue growth factor, α-smooth muscle actin (α-SMA), and collagen I was measured by real-time polymerase chain reaction.
The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.
New
Cachofeiro et al., Madrid, Spain. In J Mol Cell Cardiol, Feb 2016
However, HFD rats showed cardiac and vascular fibrosis and enhanced levels of superoxide anion (O2(-)), collagen I and transforming growth factor β (TGF-β) in heart and aorta and connective tissue growth factor (CTGF) in aorta, effects that were attenuated by LOX inhibition.
Biomarkers in systemic sclerosis: Their potential to predict clinical courses.
Review
New
Hasegawa, Fukui, Japan. In J Dermatol, Jan 2016
Other potential serum/plasma biomarkers for fibrosis and vascular involvement of SSc are connective tissue growth factor, interleukin-6, CCL2, CXCL4, intercellular adhesion molecule (ICAM)-1, P-selectin, vascular endothelial growth factor, von Willebrand factor, endostatin, endoglin and endothelin-1.
Effects of extremely low frequency pulsed magnetic fields on diabetic nephropathy in streptozotocin-treated rats.
New
Shen et al., Xi'an, China. In Biomed Eng Online, Dec 2015
Renal morphology was examined by light and electron microscopy, vascular endothelial growth factor (VEGF)-A and connective tissue growth factor (CTGF) were measured by enzyme linked immune sorbent assay.
Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data.
Beißbarth et al., Göttingen, Germany. In Front Genet, 2014
We could confirm known regulatory patterns relevant in the physiological cellular response to epidermal growth factor stimulation as well as identify interesting new interactions in this signaling context, such as the regulatory influence of the connective tissue growth factor on transferrin receptor or the influence of growth arrest and DNA-damage-inducible alpha on the connective tissue growth factor.
Hyaluronan's Role in Fibrosis: A Pathogenic Factor or a Passive Player?
Review
de la Motte et al., Cleveland, United States. In Biomed Res Int, 2014
Fibroblasts activated by cytokines or growth factors differentiate into myofibroblasts that drive fibrosis by depositing ECM molecules, such as collagen, fibronectin, and connective tissue growth factor.
Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
Review
Miao et al., Changchun, China. In J Diabetes Res, 2014
Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role.
Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities.
Review
Chaqour et al., United States. In Hum Genomics, 2014
"CCN" is an acronym referring to the first letter of each of the first three members of this original group of mammalian functionally and phylogenetically distinct extracellular matrix (ECM) proteins [i.e., cysteine-rich 61 (CYR61), connective tissue growth factor (CTGF), and nephroblastoma-overexpressed (NOV)].
Intraocular Pressure and the Mechanisms Involved in Resistance of the Aqueous Humor Flow in the Trabecular Meshwork Outflow Pathways.
Review
Fuchshofer et al., Regensburg, Germany. In Prog Mol Biol Transl Sci, 2014
This scenario leads to an overall stiffening of the inner wall region, and is modulated by transforming growth factor-β/connective tissue growth factor signaling.
Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
Impact
Lamb et al., Houston, United States. In Nat Med, 2014
Elevated levels of VAMP7 markedly intensified ESR1-potentiated transcriptional activity by increasing ESR1 protein cellular content upon ligand stimulation and upregulated the expression of estrogen-responsive genes including ATF3, CYR61 and CTGF, all of which have been implicated in human hypospadias.
Association between the CTGF -945C/G polymorphism and systemic sclerosis: a meta-analysis.
Review
GeneRIF
Tang et al., Kunming, China. In Gene, 2012
The -945CC/CG genotype greatly decreased the susceptibility of systemic sclerosis in Asians. Review.
Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts.
GeneRIF
Zhou et al., Shanghai, China. In Exp Cell Res, 2012
The MAPKs/TGFb1/TRAF6 pathway is an important signaling pathway in AngII-induced CTGF expression.
CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
GeneRIF
Sotgia et al., Philadelphia, United States. In Cell Cycle, 2012
The effects of CTGF expression on tumor formation are independent of its extracellular matrix function, but rather depend on its ability to activate catabolic metabolism.
Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis.
GeneRIF
Gao et al., Changchun, China. In World J Gastroenterol, 2012
Detection of serum CCN2 in patients with chronic hepatitis B may have clinical significance for assessment of severity of hepatic fibrosis.
Matricellular proteins in cardiac adaptation and disease.
Review
Impact
Frangogiannis, United States. In Physiol Rev, 2012
Thrombospondin (TSP)-1, -2, and -4 as well as tenascin-C and -X secreted protein acidic and rich in cysteine (SPARC), osteopontin, periostin, and members of the CCN family (including CCN1 and CCN2/connective tissue growth factor) are involved in a variety of cardiac pathophysiological conditions, including myocardial infarction, cardiac hypertrophy and fibrosis, aging-associated myocardial remodeling, myocarditis, diabetic cardiomyopathy, and valvular disease.
Concentrations of connective tissue growth factor in patients with nonalcoholic fatty liver disease: association with liver fibrosis.
GeneRIF
Tuncer et al., İstanbul, Turkey. In Dis Markers, 2011
Serum levels of CTGF may be a clinical utility for distinguishing nonalcoholic fatty liver disease patients with and without advanced fibrosis.
A polymorphism in the CTGF promoter region associated with systemic sclerosis.
Impact
GeneRIF
Abraham et al., London, United Kingdom. In N Engl J Med, 2007
The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Impact
Thomas-Tikhonenko et al., Philadelphia, United States. In Nat Genet, 2006
In addition, VEGF levels were unaffected by Myc, but enhanced neovascularization correlated with downregulation of anti-angiogenic thrombospondin-1 (Tsp1) and related proteins, such as connective tissue growth factor (CTGF).
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.
Impact
Dietz et al., Baltimore, United States. In Nat Genet, 2005
Furthermore, tissues derived from affected individuals showed increased expression of both collagen and connective tissue growth factor, as well as nuclear enrichment of phosphorylated Smad2, indicative of increased TGFbeta signaling.
More papers using connective tissue growth factor antibodies
Molecular targets for modulating lung inflammation and injury
Supplier
Fuchs Sebastien, In PLoS ONE, 2003
... Anti-CTGF and α-SMA antibodies were purchased from Abcam (Cambridge, MA), and Anti-collagen ...
Connective tissue growth factor and renal diseases: some answers, more questions
Supplier
Zhang Zhi et al., In Respiratory Research, 2003
... Goat anti-actin (C-11), Smad2 (S-20) and connective tissue growth factor (CTGF) polyclonal antibodies were supplied by Santa Cruz Biotechnology (Santa Cruz, CA) ...
Transforming growth factor-beta-induced inhibition of myogenesis is mediated through Smad pathway and is modulated by microtubule dynamic stability
Supplier
Kapus András et al., In The Journal of Cell Biology, 2003
tubulin (Sigma-Aldrich), cofilin, Smad2, phospho-Smad3, Smad4 (Cell Signaling Technology), c-Myc (clone 9E10), SRF, CTGF (Santa Cruz Biotechnology, Inc.), GAPDH (EMD), histones, ...
Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
Supplier
Denison Fiona C. et al., In Human Reproduction (Oxford, England), 1998
... Prokineticin receptor 1 antibody was purchased from Lifespan Biosciences (Atlanta, GA, USA) and the CTGF antibody was purchased from AbD Serotec (Kidlington, UK) Recombinant human ...
The genetics of disulfide bond metabolism.
Supplier
Uversky Vladimir N., In PLoS ONE, 1997
... The goat anti-human CCN2/CTGF polyclonal antibody L-20 (sc-14939) was obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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