Complement Factor B
Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.
Boston, United States. In Am J Clin Nutr, Nov 2015
Ten genetic loci in 7 genes [complement factor H (CFH), age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), complement component 2 (C2), complement factor B (CFB), complement component 3 (C3), collagen type VIII α 1 (COL8A1), and RAD51 paralog B (RAD51B)] were examined.
Structural insights on complement activation.
Madrid, Spain. In Febs J, Oct 2015
The displacement of the thio-ester-containing domain (TED) exposes hidden surfaces that mediate the interaction with complement factor B to assemble the C3-convertase of the alternative pathway (AP).
[Atypical HUS caused by complement-related abnormalities].
Nara, Japan. In Rinsho Ketsueki, Feb 2015
Many aHUS cases (approximately 70%) are reportedly caused by uncontrolled complement activation due to genetic mutations in the alternative pathway, including complement factor H (CFH), complement factor I (CFI), membrane cofactor protein (MCP), thrombomodulin (THBD), complement component C3 (C3), and complement factor B (CFB).
Atypical Hemolytic-Uremic Syndrome
Seattle, United States. In Unknown Journal, 2007
The genes: CFH (encoding complement factor H and accounting for ~30% of aHUS; CD46 (MCP) (encoding membrane cofactor protein and accounting for ~12% of aHUS); CFI (encoding complement factor I; ~5%-10% of aHUS), C3 (encoding the third component of complement C3; ~5% of aHUS); CFB (encoding complement factor B; rare); THBD (encoding thrombomodulin; ~3%-5% of aHUS); DGKE (encoding diacylglycerol kinase; ~27% of aHUS manifesting before age 1 year) .
Structure of the human interleukin-2 receptor gene.
In Science, 1985
Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement factor B. Alternative messenger RNA (mRNA) splicing may delete exon 4 sequences, resulting in a mRNA that does not encode a functional IL-2 receptor.