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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cartilage oligomeric matrix protein

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Aggrecan, ACID, AGE
Papers using Comp antibodies
Quartz crystal microbalance immunosensors for environmental monitoring
Hung Chih-Hsin et al., In Sensors (Basel, Switzerland), 2005
... COMP Human, Mouse Monoclonal Antibody, Clone:16F12 was purchased from BioVendor (Candler, NC, USA) and ...
Papers on Comp
Brain size and limits to adult neurogenesis.
Alvarez-Buylla et al., San Francisco, United States. In J Comp Neurol, Mar 2016
J. Comp.
Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development.
Rubenstein et al., San Francisco, United States. In J Comp Neurol, Mar 2016
J. Comp.
Subretinal AAV2.COMP-Ang1 Suppresses Choroidal Neovascularization and Vascular Endothelial Growth Factor in a Murine Model of Age-Related Macular Degeneration.
Ambati et al., Salt Lake City, United States. In Exp Eye Res, Feb 2016
UNASSIGNED: To assess whether Tie2-mediated vascular stabilization ameliorates neovascular age-related macular degeneration (AMD), we investigated the impact of adeno-associated virus-mediated gene therapy with cartilage oligomeric matrix protein angiopoietin-1 (AAV2.COMP-Ang1) on choroidal neovascularization (CNV), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor (HIF) in a mouse model of the disease.
COMP-assisted collagen secretion - a novel intracellular function required for fibrosis.
Eckes et al., Köln, Germany. In J Cell Sci, Feb 2016
UNASSIGNED: Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular matrix (ECM) of load-bearing tissues such as tendons and cartilage.
Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.
Thudium et al., Denmark. In Osteoarthritis Cartilage, Jan 2016
Amongst those were previously tested biomarkers such as osteocalcin, Carboxy-terminal cross-linked fragment of type II collagen (CTX-II) and cartilage oligomeric matrix protein (COMP).
Synergistic effect of blocking cancer cell invasion revealed by computer simulations.
Ichikawa, Tokyo, Japan. In Math Biosci Eng, Jan 2016
In the previous report, we found that the repetitive insertion of MT1-MMP to invadopodia was crucial for the effective degradation of ECM (Hoshino, D., et al., PLoS Comp.
Prediction and characterization of protein-protein interaction network in Bacillus licheniformis WX-02.
Chen et al., Wuhan, China. In Sci Rep, Dec 2015
Furthermore, the sub-network showed that a hub protein CcpA jointed directly or indirectly many proteins related to γ-PGA synthesis and regulation, such as PgsB, GltA, GltB, ProB, ProJ, YcgM and two signal transduction systems ComP-ComA and DegS-DegU.
Two different motor systems are needed to generate human speech.
Subramanian et al., Brisbane, Australia. In J Comp Neurol, Oct 2015
J. Comp.
The Function and Roles of ADAMTS-7 in Inflammatory Diseases.
Wei et al., Jinan, China. In Mediators Inflamm, 2014
Overexpression of ADAMTS-7 gene promotes the breakdown of cartilage oligomeric matrix protein (COMP) matrix and accelerates the progression of both surgically induced osteoarthritis and collagen-induced arthritis.
Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.
Eckes et al., Köln, Germany. In J Biol Chem, 2012
In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains.
Increased serum COMP predicts mortality in SSc: results from a longitudinal study of interstitial lung disease.
Saxne et al., Lund, Sweden. In Rheumatology (oxford), 2012
Serum COMP early in disease is a predictor of mortality in systemic sclerosis patients.
D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis.
Hecht et al., Houston, United States. In Am J Pathol, 2012
The presence of cleaved apoptosis inducing factor (tAIF) and the absence of activated caspases indicated that retention of D469del-COMP triggers cell death in chondrocytes by necroptosis, a caspase-independent programmed necrosis.
Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.
Singh et al., Shanghai, China. In Eur Cell Mater, 2011
Increased expression of collagen II, aggrecan, and cartilage oligomeric matrix protein (COMP), were observed during differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes.
European regulation on orphan medicinal products: 10 years of experience and future perspectives.
Belorgey et al., In Nat Rev Drug Discov, 2011
Since then, more than 850 orphan drug designations have been granted by the European Commission based on a positive opinion from the Committee for Orphan Medicinal Products (COMP), and more than 60 orphan drugs have received marketing authorization in Europe.
Detection of cartilage oligomeric matrix protein using a quartz crystal microbalance.
Hung et al., Kao-hsiung, Taiwan. In Sensors (basel), 2009
Detection of cartilage oligomeric matrix protein using a quartz crystal microbalance.
Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.
Imaizumi et al., Miyazaki, Japan. In Nat Cell Biol, 2009
Interestingly, proliferating chondrocytes showed abnormally expanded ER, containing aggregated type II collagen (Col2) and cartilage oligomeric matrix protein (COMP).
Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia.
Briggs et al., Manchester, United Kingdom. In Nat Genet, 2001
Mutations in the genes encoding cartilage oligomeric matrix protein (COMP) and type IX collagen (COL9A2 and COL9A3) have previously been shown to cause different forms of MED (refs.
The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?
Engel et al., Basel, Switzerland. In Science, 1996
The crystal structure of a parallel pentameric coiled coil, constituting the oligomerization domain in the cartilage oligomeric matrix protein (COMP), was determined at 2.05 angstroms resolution.
Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.
Gaines et al., Los Angeles, United States. In Nat Genet, 1995
Our data demonstrate that PSACH and some forms of MED are allelic and suggest an essential role for Ca++ binding in COMP structure and function.
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