GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 17 Jun 2013.
Collagen, type III, alpha 1
COL3A1
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008] (from
NCBI)
Sponsored links
Papers using
COL3A1
antibodies
Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?
Supplier
In Respiratory Research, 2004
... Quantitect primers for the human genes COL1A1, COL3A1 and 18s rRNA were from Qiagen (Hilden, Germany) and the ...
Papers on
COL3A1
Angiotensin II Promotes Thoracic Aortic Dissections and Ruptures in Col3a1 Haploinsufficient Mice.
New
Paris, France. In Hypertension, 31 Jul 2013
Vascular Ehlers-Danlos syndrome is a dramatic inherited disease caused by mutations of type III collagen (COL3A1) gene, associated with early-onset occurrence of arterial ruptures.
Early venous manifestation of Ehlers-Danlos syndrome Type IV through a novel mutation in COL3A1.
New
München, Germany. In Cardiovasc Pathol, 17 Jun 2013
We describe here a mutation in the intron 14 of the COL3A1 gene leading to EDS Type IV (EDS IV) associated with venous manifestations only.
[Conivaptan inhibites cell proliferation and collagen production of cardiac fibroblasts induced by arginine vasopressin].
New
Beijing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 31 May 2013
The expressions of COL1A1 and COL3A1 mRNA were detected by RT-PCR, and the protein levels of (collagen type 1, alpha 1, COL1A1) and COL3A1 were assessed by Western blotting.
Engineering three-dimensional constructs of the periodontal ligament in hyaluronan-gelatin hydrogel films and a mechanically active environment.
New
Singapore, Singapore. In J Periodontal Res, 15 May 2013
Two transcription factors (RUNX2 and PPARG), two collagens (COL1A1, COL3A1), four MMPs (MMP-1-3, TIMP-1), TGFB1, RANKL, OPG and P4HB were detected by gel electrophoresis and Ct values < 35.
Combined effects of interleukin-1α and transforming growth factor-β1 on modulation of human cardiac fibroblast function.
New
Maastricht, Netherlands. In Matrix Biol, 11 May 2013
Exposure of CF to IL-1α alone enhanced levels of IL-6, IL-8, matrix metalloproteinase-3 (MMP3) and collagen III (COL3A1), but reduced the CMF markers α-smooth muscle actin (αSMA) and connective tissue growth factor (CTGF/CCN2).
Peptide-mediated Inhibition of MK2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis.
New
Indianapolis, United States. In Am J Respir Cell Mol Biol, Apr 2013
MK2i also decreased circulating TNF-α and IL-6 levels and modulated local mRNA expression of pro-fibrotic cytokine il-1β, matrix-related genes-col1a2, col3a1, lox, and TGF-beta family members including smad3, serpine1 (pai1) and smad6/7.
A new COL3A1 mutation in Ehlers-Danlos syndrome type IV.
New
In Exp Dermatol, Mar 2013
The vascular type of the Ehlers-Danlos syndrome (Ehlers-Danlos syndrome type IV, EDS IV; OMIM #130050) is a rare connective tissue disorder with autosomal dominant transmission caused by mutations in the COL3A1 gene resulting in increased fragility of connective tissue with arterial, intestinal, and uterine ruptures and premature death.
Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep.
New
Zaragoza, Spain. In Vet Res, Dec 2012
The gene and protein expression profiles and protein distribution of six potential genetic biomarkers (i.e., CAPN6, COL1A2, COL3A1, GALA1, MT2A and MTNR1B) are presented here for both the early and terminal stages of scrapie in five different brain regions.
Genetic determinants of juvenile stroke.
Review
New
Brescia, Italy. In Thromb Res, Mar 2012
Furthermore, stroke is a well-known complication of several heritable connective tissue disorders, including Marfan's syndrome (FBN1 mutations) and Ehlers-Danlos syndrome type IV (COL3A1 mutations), which predispose to cervical artery dissection, the most frequent cause of cerebral ischemia at young age.
Vascular Ehlers-Danlos syndrome: pathophysiology, diagnosis, and prevention and treatment of its complications.
Review
Mount Vernon, United States. In Cardiol Rev, 2012
VEDS is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene.
Hemorrhagic bullae of the oral mucosa as an early manifestation of vascular-type ehlers-danlos syndrome.
GeneRIF
Yeovil, United Kingdom. In J Clin Rheumatol, 2011
Type IV, or vascular, Ehlers-Danlos Syndrome is a life-threatening, autosomal dominant condition. It is caused by mutation of the COL3A1 gene.
G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.
GeneRIF
Boston, United States. In Proc Natl Acad Sci U S A, 2011
Data show that that Col3a1 null mutant mice exhibit overmigration of neurons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the phenotype seen in Gpr56 null mutant mice.
COL3A1 haploinsufficiency results in a variety of Ehlers-Danlos syndrome type IV with delayed onset of complications and longer life expectancy.
GeneRIF
Seattle, United States. In Genet Med, 2011
COL3A1 haploinsufficiency results in a variety of Ehlers-Danlos syndrome type IV with delayed onset of complications and longer life expectancy
Biological effect of resorbable plates on normal osteoblasts and osteoblasts derived from Pfeiffer syndrome.
GeneRIF
Ferrara, Italy. In J Craniofac Surg, 2011
RT-PCR showed that COL3A1 from osteoblasts from Pfeiffer syndrome grown on PLPG acid plates were downregulated after 30 days.
The role of serum biomarkers in predicting fibrosis progression in pediatric and adult hepatitis C virus chronic infection.
GeneRIF
Buenos Aires, Argentina. In Plos One, 2010
Data suggest that combination of HA, PIIINP, TGF-ss1 may provide a potential useful tool to assess liver fibrosis in adult HCV patients.
Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial.
Impact
Paris, France. In Lancet, 2010
33 patients were positive for mutation of collagen 3A1 (COL3A1).
Spontaneous arterial dissection: phenotype and molecular pathogenesis.
Review
Heidelberg, Germany. In Cell Mol Life Sci, 2010
Genetic linkage analysis lead to the identification of mutations in different disease-causing genes involved in the biosynthesis of the extracellular matrix (FBN1, COL3A1), in transforming growth factor (TGF) beta signaling (FBN1, TGFBR1, TGFBR2) and in the SMC contractile system (ACTA2, MYH11).
The genetics of cervical artery dissection: a systematic review.
Review
London, United Kingdom. In Stroke, 2009
Two studies reported associations with polymorphisms in ICAM-1 and COL3A1, but neither has been replicated.
Connective tissue and related disorders and preterm birth: clues to genes contributing to prematurity.
Review
Richmond, United States. In Placenta, 2009
The responsible genes include COL5A1, COL5A2, COL3A1, COL1A1, COL1A2, TNXB, PLOD1, ADAMTS2, CRTAP, LEPRE1 and ZMPSTE24.
Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type.
Impact
Seattle, United States. In N Engl J Med, 2000
BACKGROUND: Ehlers-Danlos syndrome type IV, the vascular type, results from mutations in the gene for type III procollagen (COL3A1).
