GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Collagen, type III, alpha 1
COL3A1
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008] (from
NCBI)
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Papers using
COL3A1
antibodies
Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?
Supplier
In Respiratory Research, 2004
... Quantitect primers for the human genes COL1A1, COL3A1 and 18s rRNA were from Qiagen (Hilden, Germany) and the ...
Papers on
COL3A1
Peptide-mediated Inhibition of MK2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis.
New
Indianapolis, United States. In Am J Respir Cell Mol Biol, 07 Apr 2013
MK2i also decreased circulating TNF-α and IL-6 levels and modulated local mRNA expression of pro-fibrotic cytokine il-1β, matrix-related genes-col1a2, col3a1, lox, and TGF-beta family members including smad3, serpine1 (pai1) and smad6/7.
MicroRNA29: A Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation.
New
Montréal, Canada. In Circulation, 04 Apr 2013
Expression of miR29b ECM target-genes collagen-1A1 (COL1A1), collagen-3A1 (COL3A1), and fibrillin increased significantly in CHF-fibroblasts.
20S-Hydroxyvitamin D3, Noncalcemic Product of CYP11A1 Action on Vitamin D3, Exhibits Potent Antifibrogenic Activity in Vivo.
New
Memphis, United States. In J Clin Endocrinol Metab, 28 Feb 2013
Also, 20(OH)D(3), 20,23(OH)(2)D(3), and 1,25(OH)(2)D(3) suppressed TGF-β1-induced expression of COL1A2, COL3A1, and hyaluronan synthase-2 mRNA, indicating that they regulate these matrix components at the transcriptional level.
Eleutherine indica L. accelerates in vivo cutaneous wound healing by stimulating Smad-mediated collagen production.
New
Tezpur, India. In J Ethnopharmacol, 18 Feb 2013
Wound contraction measurement, hydroxyproline estimation and western blot for COL3A1, bFGF, Smad-2, 3, 4, and 7 were performed.
Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle-Invasive Bladder Transition Cell Carcinoma.
New
Madison, United States. In Plos One, Dec 2012
Further, we identified genes within this network that are similarly expressed in superficial Ta and T1 stages but altered in muscle-invasive T2 tumors, finding 7 genes (COL3A1, COL5A1, COL11A1, FN1, ErbB3, MAPK10 and CDC25C) whose expression patterns in muscle-invasive tumors are consistent in 5 to 7 independent outside microarray studies.
Vascular-type Ehlers-Danlos syndrome caused by a hitherto unknown genetic mutation: a case report.
New
Yokohama, Japan. In J Med Case Reports, Dec 2012
This revealed a heterozygous missense mutation in COL3A1, c.2411 G>T p.Gly804Val (exon 36).
Genetic determinants of juvenile stroke.
Review
New
Brescia, Italy. In Thromb Res, Mar 2012
Furthermore, stroke is a well-known complication of several heritable connective tissue disorders, including Marfan's syndrome (FBN1 mutations) and Ehlers-Danlos syndrome type IV (COL3A1 mutations), which predispose to cervical artery dissection, the most frequent cause of cerebral ischemia at young age.
Vascular Ehlers-Danlos syndrome: pathophysiology, diagnosis, and prevention and treatment of its complications.
Review
Mount Vernon, United States. In Cardiol Rev, 2012
VEDS is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene.
Meta-analytical biomarker search of EST expression data reveals three differentially expressed candidates.
Taipei, Taiwan. In Bmc Genomics, 2011
The higher-than-normal tissue expression of COL3A1, DLG3, and RNF43 in some of the cancer tissues is in agreement with our in silico predictions.
Multiplex transcriptional analysis of paraffin-embedded liver needle biopsy from patients with liver fibrosis.
Chesterfield, United States. In Fibrogenesis Tissue Repair, 2011
Statistical analysis revealed that three genes (COL3A1, KRT18, and TUBB) could separate fibrotic from non-fibrotic samples and that the expression of ten genes (ANXA2, TIMP1, CTGF, COL4A1, KRT18, COL1A1, COL3A1, ACTA2, TGFB1, LOXL2) were positively correlated with the level of liver inflammation activity.
Hemorrhagic bullae of the oral mucosa as an early manifestation of vascular-type ehlers-danlos syndrome.
GeneRIF
Yeovil, United Kingdom. In J Clin Rheumatol, 2011
Type IV, or vascular, Ehlers-Danlos Syndrome is a life-threatening, autosomal dominant condition. It is caused by mutation of the COL3A1 gene.
G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.
GeneRIF
Boston, United States. In Proc Natl Acad Sci U S A, 2011
Data show that that Col3a1 null mutant mice exhibit overmigration of neurons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the phenotype seen in Gpr56 null mutant mice.
COL3A1 haploinsufficiency results in a variety of Ehlers-Danlos syndrome type IV with delayed onset of complications and longer life expectancy.
GeneRIF
Seattle, United States. In Genet Med, 2011
COL3A1 haploinsufficiency results in a variety of Ehlers-Danlos syndrome type IV with delayed onset of complications and longer life expectancy
Biological effect of resorbable plates on normal osteoblasts and osteoblasts derived from Pfeiffer syndrome.
GeneRIF
Ferrara, Italy. In J Craniofac Surg, 2011
RT-PCR showed that COL3A1 from osteoblasts from Pfeiffer syndrome grown on PLPG acid plates were downregulated after 30 days.
The role of serum biomarkers in predicting fibrosis progression in pediatric and adult hepatitis C virus chronic infection.
GeneRIF
Buenos Aires, Argentina. In Plos One, 2010
Data suggest that combination of HA, PIIINP, TGF-ss1 may provide a potential useful tool to assess liver fibrosis in adult HCV patients.
Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial.
Impact
Paris, France. In Lancet, 2010
33 patients were positive for mutation of collagen 3A1 (COL3A1).
Spontaneous arterial dissection: phenotype and molecular pathogenesis.
Review
Heidelberg, Germany. In Cell Mol Life Sci, 2010
Genetic linkage analysis lead to the identification of mutations in different disease-causing genes involved in the biosynthesis of the extracellular matrix (FBN1, COL3A1), in transforming growth factor (TGF) beta signaling (FBN1, TGFBR1, TGFBR2) and in the SMC contractile system (ACTA2, MYH11).
The genetics of cervical artery dissection: a systematic review.
Review
London, United Kingdom. In Stroke, 2009
Two studies reported associations with polymorphisms in ICAM-1 and COL3A1, but neither has been replicated.
Connective tissue and related disorders and preterm birth: clues to genes contributing to prematurity.
Review
Richmond, United States. In Placenta, 2009
The responsible genes include COL5A1, COL5A2, COL3A1, COL1A1, COL1A2, TNXB, PLOD1, ADAMTS2, CRTAP, LEPRE1 and ZMPSTE24.
Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type.
Impact
Seattle, United States. In N Engl J Med, 2000
BACKGROUND: Ehlers-Danlos syndrome type IV, the vascular type, results from mutations in the gene for type III procollagen (COL3A1).
