Chondrogenic differentiation of marrow clots after microfracture with BMSC-derived ECM scaffold in vitro.
Nanjing, China. In Tissue Eng Part A, 26 Apr 2014
Enhanced cartilage-like matrix deposition of GAG and type II collagen were confirmed by Safranin O and immunohistochemistry staining, respectively, in Groups 2 and 4. The GAG and collagen contents also increased gradually over time in Groups 2 and 4; the increase was greater in Group 4. In addition, RT-PCR demonstrated that the expression of chondrogenic genes, such as COL2, ACAN, and SOX9, was gradually upregulated in Groups 2 and 4.
Alternative splicing and retinal degeneration.
Baltimore, United States. In Clin Genet, Aug 2013
Mutations in alternatively spliced retina-specific exons of the widely expressed RPGR and COL2A1 genes lead primarily to X-linked RP and ocular variants of Stickler syndrome, respectively.
Clinical phenotypes associated with type II collagen mutations.
Toronto, Canada. In J Paediatr Child Health, 2012
COL2A1 mutations give rise to a spectrum of phenotypes predominantly affecting cartilage and bone from the severe disorders that are perinatally lethal to the milder conditions that are recognised in the post-natal period and childhood.
Calcification of multipotent prostate tumor endothelium.
Boston, United States. In Cancer Cell, 2008
Chondrogenic differentiation was accompanied by an upregulation of cartilage-specific col2a1 and sox9, whereas osteocalcin and the metastasis marker osteopontin were upregulated during osteogenic differentiation.