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Collagen, type XXI, alpha 1

COL21A1, DKFZp564B052
This gene encodes the alpha chain of type XXI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XXI collagen is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. An alternatively spliced transcript variant has been described, but its full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CHIP, CAN, Lum, GPC6, LAMA2
Papers on COL21A1
Prognostic value of type XXII and XXIV collagen mRNA expression in head and neck cancer patients.
Mineta et al., Hamamatsu, Japan. In Mol Clin Oncol, 2014
The aim of this study was to determine the mRNA expression of type XXI, XXII, XXIII and XXIV α1 collagen (COL21A1, COL22A1, COL23A1 and COL24A1, respectively) in head and neck squamous cell carcinoma (HNSCC) and investigate its correlation with disease progression.
Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.
Zabel et al., Poznań, Poland. In Biomed Res Int, 2013
These genes included COL1A2, COL12A1, COL21A1, LOX, TGFBI, LAMB1, EFEMP1, GPC3, SDC2, MGP, MMP3, and TIMP3.
Genome-wide association study of atypical psychosis.
Yoneda et al., Takatsuki, Japan. In Am J Med Genet B Neuropsychiatr Genet, 2013
The most significant SNPs were detected around the CHN2/CPVL genes (rs245914, P = 1.6 × 10(-7)) , COL21A1 gene (rs12196860, P = 2.45 × 10(-7) ), and PYGL/TRIM9 genes (rs1959536, P = 7.73 × 10(-7) ), although none of the single-nucleotide polymorphisms exhibited genome-wide significance (P = 5 × 10(-8) ).
Pemphigus vulgaris autoantibody profiling by proteomic technique.
Grando et al., Irvine, United States. In Plos One, 2012
The top 10 antigens recognized by the majority of test patients' sera were proteins encoded by the DSC1, DSC3, ATP2C1, PKP3, CHRM3, COL21A1, ANXA8L1, CD88 and CHRNE genes.
Differential gene expression analysis related to extracellular matrix components in drug-resistant RPMI-8226 cell line.
Gündüz et al., Ankara, Turkey. In Biomed Pharmacother, 2012
However, COL21A1 which is an ECM component of the blood vessel walls, was drastically downregulated in all of the drug resistant RPMI-8226 sublines.
Detection of novel SNPs and mapping of the fatness QTL on pig chromosome 7q1.1-1.4 region.
Zuo et al., Wuhan, China. In Genet Mol Res, 2010
Eight novel markers, including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and HMGA1 genes, were genotyped in Large White and Meishan pig breeds.
Transcriptome analysis of human cancer reveals a functional role of heme oxygenase-1 in tumor cell adhesion.
Bilban et al., Vienna, Austria. In Mol Cancer, 2009
These genes included regulators of cell plasticity and extracellular matrix (ECM) remodeling (MMP2, ADAM8, TGFB1, BGN, COL21A1, PXDN), signaling (CRIP2, MICB), amino acid transport and glycosylation (SLC7A1 and ST3GAL2), estrogen and phospholipid biosynthesis (AGPAT2 and HSD17B1), protein stabilization (IFI30), and phosphorylation (ALPPL2).
Genomic structure and gene order of swine chromosome 7q1.1-->q1.2.
Uenishi et al., Tsukuba, Japan. In Anim Genet, 2006
Analysis of the nucleotide sequences of three BAC clones that included the rearrangement point demonstrated that COL21A1 and DST, which were not present in the corresponding human region, were located adjacent to the rearrangement point.
Why mice have lost genes for COL21A1, STK17A, GPR145 and AHRI: evidence for gene deletion at evolutionary breakpoints in the rodent lineage.
Bateman et al., Melbourne, Australia. In Trends Genet, 2004
In this article, we present evidence of four human genes (COL21A1, STK17A, GPR145 and ARHI) that are located in regions corresponding to evolutionary breakpoints in rodents and lack mouse and rat orthologues.
Genomic organization and characterization of the human type XXI collagen (COL21A1) gene.
Li et al., China. In Genomics, 2002
Assembly of the genomic data reveals a complete sequence of the human gene COL21A1.
Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen family.
Tuckwell, Manchester, United Kingdom. In Matrix Biol, 2002
Bioinformatics analysis of cDNA clone DKFZp564B052 showed that it resembled the FACIT collagens and was therefore designated collagen alpha 1(XXI).
A new FACIT of the collagen family: COL21A1.
Bateman et al., Melbourne, Australia. In Febs Lett, 2001
Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12.
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