Paracrine effects of mesenchymal stem cells induce senescence and differentiation of glioblastoma stem-like cells.
In Cell Transplant, 24 Apr 2015
Among these ATM, CD44, COL1A1, MORC3, NOX4, CDKN1A, IGFBP5, SERPINE1 genes were up-regulated, whereas IGFBP3, CDKN2A, CITED2, FN1, PRKCD genes were found to be down-regulated.
Effects of moderate intensity static magnetic fields on human bone marrow-derived mesenchymal stem cells.
Oral, Kazakhstan. In Bioelectromagnetics, 21 Apr 2015
In the same manner, they upregulated expression of osteogenic marker genes such as ALP, bone sialoprotein 2 (BSP2), collagen1a1 (COL1a1), osteocalcin (OCN), osteonectin (ON), osteopontin (OPN), osterix (OSX), and runt-related transcription factor 2 (RUNX2) with peak at 15 mT after 14 or 21 days of exposure.
Smad4 Loss Synergizes with TGFα Overexpression in Promoting Pancreatic Metaplasia, PanIN Development, and Fibrosis.
New York City, United States. In Plos One, Dec 2014
Expression analyses of fibrosis, pancreatitis, or desmoplasia associated markers (α-SMA, Shh, COX-2, Muc6, Col1a1, and Ctgf) were performed by IHC and/or qRT-PCR.
Gibbon genome and the fast karyotype evolution of small apes.
Portland, United States. In Nature, Oct 2014
Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.
Mouse models for the evaluation of osteocyte functions.
Nagasaki, Japan. In J Bone Metab, Feb 2014
Overexpression of Bcl-2 in osteoblasts using 2.3 kb collagen type I alpha1 (COL1A1) promoter causes osteocyte apoptosis due to the severe reduction in the number of osteocyte processes, resulting in the disruption of both intracellular and extracellular communication systems.
An introduction of genetics in otosclerosis: a systematic review.
Utrecht, Netherlands. In Otolaryngol Head Neck Surg, 2014
These high-quality studies show that otosclerosis in Japanese patients is not linked to the NOG gene and that a polymorphism in the Sp1 binding site located on the COL1A1 gene is associated with otosclerosis as well as OTSC1.