Osteogenic potential of human adipose-tissue derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium.
Rochester, United States. In Gene, Feb 2016
Compared to standard tissue culture plastic, AMSCs grown in the porous titanium microenvironment showed differences in temporal expression for genes involved in cell cycle progression (CCNB2, HIST2H4), extracellular matrix production (COL1A1, COL3A1), mesenchymal lineage identity (ACTA2, CD248, CD44), osteoblastic transcription factors (DLX3, DLX5, ID3) and epigenetic regulators (EZH1, EZH2).
Madagascar. In Unknown Journal, May 2015
The classical Sillence types of OI (types I-IV) with autosomal dominant inheritance comprise about 85% of cases and are caused by mutations in the genes that encode type I collagen, COL1A1 and COL1A2.
Role and New Insights of Pirfenidone in Fibrotic Diseases.
Guadalajara, Mexico. In Int J Med Sci, 2014
Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-β1, TNF-α, PDGF and COL1A1 expression, which is highly related to prevent or remove excessive deposition of scar tissue in several organs.
Osteoarthritis year in review 2014: genetics and genomics.
Lárisa, Greece. In Osteoarthritis Cartilage, 2014
In OA synovium elevation of collagens and cross-linking enzymes (COL1A1, COL5A1, PLOD2, LOX and TIMP1) responsive to TGF-β was found as well as differential expression pattern between different areas of the osteoarthritic synovial membrane.
Gibbon genome and the fast karyotype evolution of small apes.
Portland, United States. In Nature, 2014
Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.