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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Collagen, type XVIII, alpha 1

COL18A1, collagen type XVIII-alpha1, endostatin
intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, CAN, HAD, V1a, AGE
Papers using COL18A1 antibodies
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
Supplier
Hu Sanyuan et al., In International Journal of Nanomedicine, 1997
... Polyvinyl alcohol (PVA, molecular weight 13–23 kDa) and the primary antibodies for endostatin were purchased from Sigma-Aldrich (St Louis, MO) and Santa Cruz Biotechnology (Santa Cruz, CA), respectively ...
Papers on COL18A1
Plasma endostatin may improve acute kidney injury risk prediction in critically ill patients.
New
Larsson et al., Sweden. In Ann Intensive Care, 31 Dec 2016
Such collagen breakdown releases endostatin into the circulation.
Proteoglycans in liver cancer.
Review
New
Kovalszky et al., Budapest, Hungary. In World J Gastroenterol, Feb 2016
This article details and discusses the roles of syndecan-1, glypicans, agrin, perlecan, collagen XVIII/endostatin, endocan, serglycin, decorin, biglycan, asporin, fibromodulin, lumican, and versican in liver function.
Biomarkers in systemic sclerosis: Their potential to predict clinical courses.
Review
New
Hasegawa, Fukui, Japan. In J Dermatol, Jan 2016
Other potential serum/plasma biomarkers for fibrosis and vascular involvement of SSc are connective tissue growth factor, interleukin-6, CCL2, CXCL4, intercellular adhesion molecule (ICAM)-1, P-selectin, vascular endothelial growth factor, von Willebrand factor, endostatin, endoglin and endothelin-1.
Brain microangiopathy and macroangiopathy share common risk factors and biomarkers.
New
Lee et al., Seoul, South Korea. In Atherosclerosis, Jan 2016
Inflammatory biomarkers (C-reactive protein, E-selectin, and LpPLA2), endothelial dysfunction (asymmetric dimethylarginine, urinary albumin-to-creatinine ratio, endostatin, and homocysteine), atherogenesis (lipoprotein(a), adiponectin, and resistin), and renal function (creatinine clearance and estimated glomerular filtration rate) were assessed.
Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications.
Review
New
Azar et al., Chicago, United States. In Biochim Biophys Acta, Dec 2015
Endostatin, a 20-kDa C-terminal fragment of type XVIII collagen, is one of the most potent inhibitors of angiogenesis.
Deciphering the anti-angiogenic effect of endostatin/cyclophosphamide to normalize tumor micrangium through notch signaling pathway in colon cancer.
New
Wang et al., Dalian, China. In World J Surg Oncol, Dec 2015
Endostatin is an important anti-angiogenic agent, and the additive effect of endostatin with a chemotherapeutic agent, cyclophosphamide, on micrangium has not been established.
Expression of Proinflammatory Factors, Proangiogenic Factors and Endostatin in Patients with Heart Failure and Different Grades of Collateral Circulation Development.
New
Mysiak et al., Wrocław, Poland. In Adv Clin Exp Med, Nov 2015
OBJECTIVES: The purpose of this study was to assess the changes in serum concentrations of pro-inflammatory factor IL-6, growth factors FGF (FGFa, FGFb, FGFbH), HGF, VEGF and endostatin in heart failure patients in relation to the coronary collaterals development stage.
Possible role of endostatin in the antiangiogenic therapy of diabetic retinopathy.
Review
New
Kotwani et al., Delhi, India. In Life Sci, Sep 2015
Endostatin is one such antiangiogenic agent being studied at present.
Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cells in A549 transplantation tumors.
Luo et al., Chengdu, China. In Cell Biosci, 2014
Endostatin (ES) is one of the most widely-used anti-angiogenic drugs for lung cancer in China, and resistance to it is a barrier that needs to be resolved.
Colon Targeted Liposomal Systems (CTLS): Theranostic Potential.
Review
Jain et al., Sāgar, India. In Curr Mol Med, 2014
RGD, NGR, fibronectin mimetic peptide, and transferrin), Sialyl Lewis X (SLX), low molecular weight ligand like folate, monoclonal antibodies, endostatin gene and sulfatide etc.
Functionally conserved cis-regulatory elements of COL18A1 identified through zebrafish transgenesis.
GeneRIF
Fisher et al., São Paulo, Brazil. In Dev Biol, 2010
These results provide important insight into the biological function and regulation of COL18A1, and point to additional sequences that may contribute to complex diseases involving COL18A1.
Inhibition of endostatin/collagen XVIII deteriorates left ventricular remodeling and heart failure in rat myocardial infarction model.
GeneRIF
Isobe et al., Tokyo, Japan. In Circ J, 2010
Endogenous endostatin/collagen XVIII may suppress aberrant left ventricular remodeling and heart failure after myocardial infarction.
Lesional expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following traumatic brain injury (TBI).
GeneRIF
Schwab et al., Tübingen, Germany. In Exp Neurol, 2007
Late increase in endostatin/collagen XVIII(+) microglia/macrophages and increased endostatin/collagen XVIII(+) subendothelial cells/vessels in areas of vascular remodeling. Role in termination of transient angiogenesis, linked to late inflammation.
Spinal cord injury-induced expression of the antiangiogenic endostatin/collagen XVIII in areas of vascular remodelling.
GeneRIF
Schwab et al., Tübingen, Germany. In J Neurosurg Spine, 2007
Expression of endostatin/collagen XVIII by macrophages in a "late" activated phagocytic mode suggests that this factor plays a role in counteracting the preceding "early" neoangiogenic response after spinal cord injury.
Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors.
Impact
Fuchs et al., Boston, United States. In J Clin Oncol, 2006
PURPOSE: Endostatin is a 20-kd proteolytic fragment of collagen XVIII that, in preclinical studies, has been shown to have antiangiogenic and antitumor activity.
The myotomal diwanka (lh3) glycosyltransferase and type XVIII collagen are critical for motor growth cone migration.
GeneRIF
Granato et al., Philadelphia, United States. In Neuron, 2006
diwanka (lh3) acts through myotomal type XVIII collagen, a ligand for neural-receptor protein tyrosine phosphatases that guide motor axons
Endostatin's endpoints-Deciphering the endostatin antiangiogenic pathway.
Review
Impact
Rafii et al., New York City, United States. In Cancer Cell, 2004
In a recent report, have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin.
Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors.
Impact
Wilding et al., Madison, United States. In J Clin Oncol, 2003
PURPOSE: Endostatin is the first endogenous angiogenesis inhibitor to enter clinical trials.
Phase I study of recombinant human endostatin in patients with advanced solid tumors.
Impact
Abbruzzese et al., Houston, United States. In J Clin Oncol, 2002
PURPOSE: Endostatin, a 20-kd fragment of collagen XVIII, is a potent inhibitor of angiogenesis.
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.
Impact
Abbruzzese et al., Houston, United States. In J Clin Oncol, 2002
We present the initial results of a dose-finding clinical trial of recombinant human endostatin (rh-Endo) that examined potential surrogates for response to antiangiogenic therapy.
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