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Collagen, type XVI, alpha 1

COL16A1, alpha1 type XVI collagen, 447 aa
This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, E-cadherin, POLYMERASE, MT3-MMP, FGFR2
Papers on COL16A1
Genome-wide RNA-Seq analysis of breast muscles of two broiler chicken groups differing in shear force.
New
Gurgul et al., Poland. In Anim Genet, Feb 2016
In the down-regulated gene group, genes which play a role in lipogenesis (THRSP, PLIN1) and in collagen synthesis (P4HA3, LEPREL4, PCOLCE2, COL16A1, COL20A1, VWA1) were detected.
Mapping molecular differences and extracellular matrix gene expression in segmental outflow pathways of the human ocular trabecular meshwork.
Acott et al., Portland, United States. In Plos One, 2014
Several collagen genes (COL16A1, COL4A2, COL6A1 and 2) and MMPs (1, 2, 3) were enriched in high, whereas COL15A1, and MMP16 were enriched in low flow regions.
Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees.
Lee et al., Taipei, Taiwan. In Osteoarthritis Cartilage, 2013
The expression levels of 19 genes were statistically significantly correlated with the severity of AC degeneration and changes of SB structure; these included: ADAMTS1, ASPN, BMP6, BMPER, CCL2, CCL8, COL5A1, COL6A3, COL7A1, COL16A1, FRZB, GDF10, MMP3, OGN, OMD, POSTN, PTGES, TNFSF11 and WNT1.
Epidermolysis bullosa - a group of skin diseases with different causes but commonalities in gene expression.
Krammer et al., Salzburg, Austria. In Exp Dermatol, 2012
Type XVI collagen (COL16A1), G0/G1 switch 2 (G0S2), fibronectin (FN1), ribosomal protein S27A (RPS27A) and low density lipoprotein receptor (LDLR) were shown to exhibit corresponding changes in gene expression in all three EB subtypes.
Transcriptional expression of type-I interferon response genes and stability of housekeeping genes in the human endometrium and endometriosis.
Martensen et al., Århus, Denmark. In Mol Hum Reprod, 2011
The IFN-specific PCR array indicated significantly different expression of the genes BST2, COL16A1, HOXB2 and ISG20 between the endometrial tissue types.
Induction of type XVI collagen expression facilitates proliferation of oral cancer cells.
GeneRIF
Bauer et al., Regensburg, Germany. In Matrix Biol, 2011
Overexpression of type XVI collagen in aberrant oral keratinocytes leads to Kindlin-1 induction, increased Kindlin-1/beta1-integrin interaction, integrin activation and subsequently to a proliferative cellular phenotype.
Collagen XVI induces formation of focal contacts on intestinal myofibroblasts isolated from the normal and inflamed intestinal tract.
GeneRIF
Grässel et al., Regensburg, Germany. In Matrix Biol, 2010
Collagen XVI promotes persistence of intestinal subepithelial myofibroblasts in the normal and in the inflamed bowel wall by stabilizing focal adhesion contacts.
Enhanced human bone marrow stromal cell affinity for modified poly(L-lactide) surfaces by the upregulation of adhesion molecular genes.
Xiao et al., Brisbane, Australia. In Biomaterials, 2009
Six adhesion genes (CDH1, ITGL, NCAM1, SGCE, COL16A1, and LAMA3) were most significantly influenced by the modified PLLA surfaces.
Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis.
Tanaka et al., Niigata, Japan. In Cancer Sci, 2009
Of the 48 genes selected for biological function by gene ontology analysis or Ingenuity Pathway Analysis, five genes (ZEB2, CDH1, LTBP2, COL16A1, and ACTA2) were extracted as candidates for prognostic factors associated with progression-free survival.
Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion.
GeneRIF
Paulus et al., Münster, Germany. In Febs Lett, 2008
These results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.
Molecular structure and interaction of recombinant human type XVI collagen.
GeneRIF
Grässel et al., Münster, Germany. In J Mol Biol, 2004
interacts with fibrillin-1 and with fibronectin indicating multiple molecular interactions in which this ubiquitously expressed and versatile fibril-associated collagens with interrupted triple helices-collagen can participate
Regulators of G-protein signaling 3 and 4 (RGS3, RGS4) are associated with glioma cell motility.
Paulus et al., Münster, Germany. In J Neuropathol Exp Neurol, 2004
Specifically, differentially expressed genes included those encoding extracellular matrix components (COL16A1, DPT), proteases (CATD, PRSS11), cytokines (MDK, IL8), transport proteins (SLC1A3, ATP10B), cytoskeleton constituents (ACTA2, ACTSG, NEFL), DNA repair enzymes (WRN, ADPRTL2), and G-protein signaling components (GNA12, RGS3, RGS4).
Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation.
Giudice et al., Stanford, United States. In Physiol Genomics, 2004
Most abundantly downregulated genes included activator of NF-kappaB, actin/tropomyosin/calmodulin binding protein, cyclin B, IGFBP-5, alpha1 type XVI collagen, lipocortin III, l-kynurenine hydrolase, frizzle-related protein, and cyclin E2.
Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.
GeneRIF
Grässel et al., Münster, Germany. In Matrix Biol, 2003
Not in banded collagen fibrils in dermis, but is component of specialized fibrillin-1-containing microfibrils. In cartilage matrix not in aggregates with fibrillin-1. Resides in thin, weakly banded collagen fibrils also containing collagens II and XI.
In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis.
Prockop et al., New Orleans, United States. In Proc Natl Acad Sci U S A, 2002
In addition, two collagens (COL3A1 and COL16A1), a signaling molecule (WNT11), a homeobox homolog (BAPX1), a receptor (IL-1R1), an IGFs modulator (IGFBP5), and a mettaloproteinase (MMP16) increased progressively up to about day 14, suggesting roles later in chondrogenesis.
Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments.
Nagai et al., Tokyo, Japan. In J Biochem, 1992
The gene of alpha 1(XVI) chain, COL16A1, is mapped on the short arm of human chromosome 1 (1p13-p34).
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