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Coiled-coil alpha-helical rod protein 1

Coiled-Coil alpha-Helical Rod protein 1, CCHCR1, H cr
Top mentioned proteins: ROD, HAD, STAT3, HLA-B, AGE
Papers on Coiled-Coil alpha-Helical Rod protein 1
Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study.
New
Lei et al., Suzhou, China. In J Clin Neurol, Oct 2015
In particular, four of the novel genes, those encoding myelin oligodendrocyte glycoprotein (MOG), coiled-coil alpha-helical rod protein 1 (CCHCR1), human leukocyte antigen complex group 22 (HCG22), and major histocompatibility complex, class II, DM alpha (HLA-DMA), were supported by the evidence of both.
Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants.
New
Pandey-Rai et al., Benares, India. In Protoplasma, Jun 2015
Increased leukocyte recruitment and elevated levels of cytokines, growth factors and genetic factors like interleukin (IL)-1β, IL-6, IL-17, IL-22, IL-23, tumour necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, toll-like receptor (TLR)-2, signal transducer and activator of transcription (STAT-3), 15-lipoxygenase (LOX)-2, coiled-coil alpha-helical rod protein 1 (CCHCR1), steroidogenic acute regulatory protein (StAR) and vitamin D receptor (VDR) are the most critical factors governing the exacerbation of psoriasis.
Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis.
Abad-Santos et al., Madrid, Spain. In J Immunol Res, 2014
When we compared type I psoriasis with type II psoriasis (N = 36), we found a significant association between age at onset and the genes PSORS6, TNF-α, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1.
Alu-mediated large deletion of the CDSN gene as a cause of peeling skin disease.
Yachie et al., Kanazawa, Japan. In Clin Genet, 2014
Several genes including C6orf15, PSORS1C1, PSORS1C2, CCHCR1, and TCF19 were also deleted, however, the patient showed only clinical features typical of PSD.
CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.
Liu et al., Hong Kong, Hong Kong. In Exp Cell Res, 2014
Coiled-coil alpha-helical rod protein 1 (CCHCR1) is suggested as a candidate biomarker for psoriasis for more than a decade but its function remains poorly understood because of the inconsistent findings in the literature.
Homozygous deletion of six genes including corneodesmosin on chromosome 6p21.3 is associated with generalized peeling skin disease.
Hashimoto et al., Kurume, Japan. In J Dermatol Sci, 2014
Multiplex ligation-dependent probe amplification and genomic quantitative real-time PCR analyses detected large homozygous deletion of 59,184bp extending from 40.6kb upstream to 13.2kb downstream of CDSN, which included 6 genes (TCF19, CCHCR1, PSORS1C2, PSORS1C1, CDSN and C6orf15).
CCHCR1 interacts specifically with the E2 protein of human papillomavirus type 16 on a surface overlapping BRD4 binding.
Demeret et al., Paris, France. In Plos One, 2013
We identified an interaction between E2 and a cellular protein called CCHCR1, which proved highly specific for the HPV16 genotype, the most prevalent in HPV-associated cancers.
Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis.
Eeles et al., Manchester, United Kingdom. In Bju Int, 2013
After applying a Bonferroni correction for the number of SNPs tested, the SNP mapping to CCHCR1 (rs130067) retained statistically significant evidence for association (P = 6 × 10(-4) ; odds ratio [OR] = 1.15, 95% CI: 1.06-1.24);
Analysis of the coding sequence and expression of the coiled-coil α-helical rod protein 1 gene in normal and neoplastic epithelial cervical cells.
Goździcka-Józefiak et al., Poznań, Poland. In Int J Mol Med, 2012
The role of the CCHCR1 (coiled-coil α-helical rod protein 1) protein in the cell is poorly understood.
Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization.
Elomaa et al., Helsinki, Finland. In Plos One, 2011
CCHCR1 (Coiled-Coil α-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with the psoriasis associated risk allele CCHCR1*WWCC.
Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.
Nakamura et al., Bangkok, Thailand. In Clin Infect Dis, 2011
RESULTS: The genome-wide association analysis and replication studies of candidate SNPs identified significant associations of nevirapine-induced rash with 2 SNPs (rs1265112 and rs746647) within CCHCR1 on chromosome 6p21.3
Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC.
Anastassiou et al., New York City, United States. In Hum Genet, 2011
A subsequent LD analysis established TCF19, POU5F1, CCHCR1 and PSORS1C1 as potential causal genes for the observed association.
Psoriasis-associated genetic polymorphism in North Indian population in the CCHCR1 gene and in a genomic segment flanking the HLA-C region.
Aggarwal et al., Amritsar, India. In Dis Markers, 2010
Association of the disease with human leukocyte antigen (HLA) Cw6, corneodesmosin (CDSN) and the coiled-coil alpha-helical rod protein-1 (CCHCR1) has also been reported.
CCHCR1 is up-regulated in skin cancer and associated with EGFR expression.
Saarialho-Kere et al., Helsinki, Finland. In Plos One, 2008
Aberrant function of the CCHCR1 gene (Coiled-Coil alpha-Helical Rod protein 1, HCR) within the PSORS1 locus may contribute to the onset of psoriasis.
Mapping and identifying genes for asthma and psoriasis.
Review
Kere, Huddinge, Sweden. In Philos Trans R Soc Lond B Biol Sci, 2005
I review two examples of such challenges: the cloning of GPR154 (GPRA) and AAA1 on chromosome 7p14 at a susceptibility locus for atopy and asthma, and the study of HLA-Cw6, CCHCR1 (HCR) and CDSN on chromosome 6p21 at PSORS1, the major susceptibility locus for psoriasis.
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