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COG4 Cog4p

COG4, SEC38, Cog4p
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010] (from NCBI)
Papers on COG4
Golgi function and dysfunction in the first COG4-deficient CDG type II patient.
Matthijs et al., Leuven, Belgium. In Hum Mol Genet, 2009
A novel R729W missense mutation in COG4 was associated with the congenital disorder of glycosylation type II.
Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.
Hughson et al., Princeton, United States. In Proc Natl Acad Sci U S A, 2009
The 1.9 A crystal structure of a Cog4 C-terminal fragment, was determined. Arg 729 is found to occupy a key position at the center of a salt bridge network, thereby stabilizing Cog4's small C-terminal domain.
Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing.
Lev et al., Israel. In Embo J, 2009
Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG) tethering complex; Sly1-COG interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 through a different binding site.
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