COG complexes form spatial landmarks for distinct SNARE complexes.
Little Rock, United States. In Nat Commun, 2012
Here, using yeast two-hybrid and co-immunoprecipitation approaches, we show that three COG subunits, namely COG4, 6 and 8, are capable of interacting with defined Golgi SNAREs, namely STX5, STX6, STX16, GS27 and SNAP29.
Identification of the first COG-CDG patient of Indian origin.
Los Angeles, United States. In Mol Genet Metab, 2011
Here we present data identifying a previously reported CDG-IIx case from Singapore as a new COG4 patient with 2 novel mutations leading to p.E233X and p.L773R; with p.E233X being a de novo mutation.
Molecular organization of the COG vesicle tethering complex.
Princeton, United States. In Nat Struct Mol Biol, 2010
To begin elucidating the molecular architecture of one well-studied example, the conserved oligomeric Golgi (COG) complex, we reconstituted its essential subunits (Cog1, Cog2, Cog3 and Cog4) and used single-particle electron microscopy to reveal a y-shaped structure with three flexible, highly extended legs.