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CART prepropeptide

Cocaine and amphetamine-regulated transcript, CARTPT, CART(1-39)
This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: Neuropeptide, Insulin, CAN, leptin, fibrillin-1
Papers on Cocaine and amphetamine-regulated transcript
MCG101-induced cancer anorexia-cachexia features altered expression of hypothalamic Nucb2 and Cartpt and increased plasma levels of cocaine- and amphetamine-regulated transcript peptides.
New
Smedh et al., Göteborg, Sweden. In Oncol Rep, Feb 2016
Expression of mRNA for corticotropin-releasing hormone (CRH), cocaine- and amphetamine-regulated transcript (CART), nesfatin-1, thyrotropin (TSH) and the TSH receptor were explored.
Energy homeostasis genes and breast cancer risk: The influence of ancestry, body size, and menopausal status, the breast cancer health disparities study.
New
John et al., Salt Lake City, United States. In Cancer Epidemiol, Dec 2015
as was cocaine and amphetamine regulated transcript protein (CARTPT) (PARTP=0.014)
Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation.
New
Gozal et al., Chicago, United States. In Int J Obes (lond), Jul 2015
A large proportion of the DMR-associated genes have reported functions that are altered in obesity and metabolic syndrome, such as Cartpt, Akt2, Apoe, Insr1 and so on.
LKB1 and AMPK differentially regulate pancreatic β-cell identity.
Rutter et al., Jerusalem, Israel. In Faseb J, 2014
Loss of LKB1 strikingly (2.0-12-fold, E<0.01) increased the expression of subsets of hepatic (Alb, Iyd, Elovl2) and neuronal (Nptx2, Dlgap2, Cartpt, Pdyn) genes, enhancing glutamate signaling.
Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens.
Gammie et al., Madison, United States. In Front Behav Neurosci, 2013
Over 100 addiction/reward related genes were identified and these included: Per1, Per2, Arc, Homer2, Creb1, Grm3, Fosb, Gabrb3, Adra2a, Ntrk2, Cry1, Penk, Cartpt, Adcy1, Npy1r, Htr1a, Drd1a, Gria1, and Pdyn.
Regulation of granulosa cell cocaine and amphetamine regulated transcript (CART) binding and effect of CART signaling inhibitor on granulosa cell estradiol production during dominant follicle selection in cattle.
Smith et al., East Lansing, United States. In Biol Reprod, 2013
We previously established a potential role for cocaine and amphetamine regulated transcript (CARTPT) in dominant follicle selection in cattle.
Regulation and regulatory role of WNT signaling in potentiating FSH action during bovine dominant follicle selection.
Smith et al., East Lansing, United States. In Plos One, 2013
In contrast, FSH reduced CARTPT mRNA and IWR-1 partially reversed the inhibitory effect of FSH.
Distribution pattern of CART-containing neurons and cells in the human pancreas.
GeneRIF
Lebkowski et al., Białystok, Poland. In Acta Histochem, 2012
The first report on the presence of CART-IR structures in the normal human pancreas.
The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer.
GeneRIF
Gallagher et al., Dublin, Ireland. In Oncogene, 2012
It was shown that cocaine- and amphetamine-regulated transcript protein (CART) increases the transcriptional activity of estrogen receptor alpha and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal.
Expression of cocaine- and amphetamine-regulated transcript is associated with worse survival in small bowel carcinoid tumors.
GeneRIF
Wierup et al., Jönköping, Sweden. In Clin Cancer Res, 2012
Expression of CART in small bowel carcinoid tumors is associated with worse survival.
The endocrine role of the skeleton: background and clinical evidence.
Review
Obermayer-Pietsch et al., Graz, Austria. In Eur J Endocrinol, 2012
The second pathway functions via the activation of CART (CARTPT) and inhibits bone resorption.
Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine.
Przewlocki et al., Kraków, Poland. In Genes Brain Behav, 2012
The analysis also showed a drug-regulated group of transcripts enriched in the nucleus accumbens and includes well known (Pdyn, Cartpt and Rgs2) as well as new (Fam40b and Inmt) candidate genes.
Molecular characterization of CART, AgRP, and MC4R genes and their expression with fasting and re-feeding in common carp (Cyprinus carpio).
Sun et al., Beijing, China. In Mol Biol Rep, 2012
Cocaine and amphetamine-regulated transcript (CART), agouti-related proteins (AgRP) and Melanocortin 4 Receptor (MC4R) involves in the control of appetite.
Association of the Cocaine- and Amphetamine-Regulated Transcript Prepropeptide Gene (CARTPT) rs2239670 Variant with Obesity among Kampar Health Clinic Patrons, Malaysia.
Yee- et al., Kampar, Malaysia. In Malays J Med Sci, 2012
The study objective was to investigate the association of the CART prepropeptide gene (CARTPT) rs2239670 variant with obesity and its related anthropometric indicators among patients of a Malaysian health clinic in Kampar, Perak, Malaysia.
CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria.
GeneRIF
Reddy et al., Beaverton, United States. In Plos One, 2011
CART is an antioxidant peptide
Expression of material mRNA in the hypothalamus and frontal cortex in a rat model of fatal hypothermia.
Ikeda et al., Fukuoka, Japan. In Leg Med (tokyo), 2011
The expression of aldehyde dehydrogenase 6 family, member A1 (ALDH6A1), cocaine- and amphetamine-regulated transcript peptide (CARTPT), desmin (DES), heat shock 70kDa protein 4 (HSPA4), serotonin receptor 2A (HTR2A), opioid receptor, delta 1 (OPRD1) and transthyretin (TTR) supposedly related to fatal hypothermia was determined using quantitative real-time PCR.
Single-chain variable fragments antibody of CART inhibits the expression of cocaine-induced behavioral sensitization.
You et al., Shanghai, China. In Neuroreport, 2011
Cocaine and amphetamine-regulated transcript (CART) peptides are neurotransmitters with important roles in drug abuse.
Association of cocaine- and amphetamine-related transcript, leptin and leptin receptor gene polymorphisms with anthropometric obesity phenotype indicators in South African learners.
GeneRIF
Matsha et al., Cape Town, South Africa. In J Nutrigenet Nutrigenomics, 2010
The CART c.517A-->G polymorphism was significantly associated with obesity susceptibility.
Putative role of cocaine- and amphetamine-regulated transcript (CARTPT) in dominant follicle selection in cattle.
Review
Ireland et al., East Lansing, United States. In Soc Reprod Fertil Suppl, 2009
Recent evidence indicates cocaine and amphetamine regulated transcript (CARTPT), with intraovarian expression only in single-ovulating species, is a novel regulator of follicular development.
The Creb1 coactivator Crtc1 is required for energy balance and fertility.
Impact
Montminy et al., Los Angeles, United States. In Nat Med, 2008
Dephosphorylated Crtc1 stimulated expression of the Cartpt and Kiss1 genes, which encode hypothalamic neuropeptides that mediate leptin's effects on satiety and fertility.
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