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Coenzyme A synthase

CoA synthase, 4'-phosphopantetheine adenylyltransferase and dephospho-CoA kinase
Top mentioned proteins: ACID, CAN, HAD, STEP, V1a
Papers on CoA synthase
Long-term feeding a plant-based diet devoid of marine ingredients strongly affects certain key metabolic enzymes in the rainbow trout liver.
New
Médale et al., France. In Fish Physiol Biochem, Feb 2016
Hydroxymethylglutaryl-CoA synthase expression was also induced by plant-based diet because of the low rate of cholesterol in the diet.
Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism.
New
Redmond et al., United States. In J Biol Chem, Jan 2016
To investigate potential interactions between RPE65 and lipid metabolism enzymes, HEK293-F cells were transfected with expression vectors for visual cycle proteins and co-transfected with either fatty acyl:CoA ligases (ACSLs) 1, 3 or 6, or the SLC27A family fatty acyl-CoA synthase FATP2/SLCA27A2 to test their effect on isomerase activity.
Spatial and temporal regulation of sterol biosynthesis in Nicotiana benthamiana.
New
Chappell et al., Ames, United States. In Physiol Plant, Jan 2016
Consistent with the precursor incorporation data, analysis of gene transcript and measurements of putative rate-limiting enzyme activities for HMG-CoA synthase (EC 2.3.3.10) and reductase (EC 1.1.1.34)
A novel MVA-mediated pathway for isoprene production in engineered E. coli.
New
Liu et al., Qingdao, China. In Bmc Biotechnol, Dec 2015
A novel biosynthetic pathway of isoprene in E. coli was established by co-expressing the heterologous mvaE gene encoding acetyl-CoA acetyltransferase/HMG-CoA reductase and mvaS gene encoding HMG-CoA synthase from Enterococcus faecalis, fatty acid decarboxylase (OleTJE) and oleate hydratase (OhyAEM).
Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.
New
Uzu et al., Ōtsu, Japan. In Sci Rep, Dec 2015
Interestingly, renal as well as hepatic expression of HMG-CoA synthase 2 increased with prolonged starvation.
Utilization of digital differential display to identify differentially expressed genes related to rumen development.
Review
New
Roh et al., Nayoro, Japan. In Anim Sci J, Oct 2015
Among the 11 genes, only 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), aldo-keto reductase family 1, member C1-like (AKR1C1), and fatty acid binding protein 3 (FABP3) showed significant changes in the levels of gene expression in the rumen between the pre- and post-weaning of calves.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: urinary organic acid profiles and expanded spectrum of mutations.
Review
New
Zschocke et al., Australia. In J Inherit Metab Dis, May 2015
Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase (HMCS2) deficiency results in episodes of hypoglycemia and increases in fatty acid metabolites.
Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes.
Review
Tiranti et al., Milano, Italy. In Biochem Soc Trans, 2014
A distinct form of NBIA, denominated CoPAN (CoA synthase protein-associated neurodegeneration), is caused by mutations in the CoASY (CoA synthase) gene coding for a bifunctional mitochondrial enzyme, which catalyses the final steps of CoA biosynthesis.
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Impact
Verdin et al., Novato, United States. In Cell Metab, 2014
In addition, we demonstrate that SIRT5 regulates succinylation of the rate-limiting ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) both in vivo and in vitro.
Investigations of the efficient electrocatalytic interconversions of carbon dioxide and carbon monoxide by nickel-containing carbon monoxide dehydrogenases.
Review
Armstrong et al., Oxford, United Kingdom. In Met Ions Life Sci, 2013
Experiments carried out on a much larger (Class III) enzyme CODH/ACS, in which CODH is complexed tightly with acetyl-CoA synthase, show that some of these characteristics are retained, albeit with much slower rates of interfacial electron transfer, attributable to the difficulty in making good electronic contact at the electrode.
Carbon monoxide. Toxic gas and fuel for anaerobes and aerobes: carbon monoxide dehydrogenases.
Review
Dobbek et al., Berlin, Germany. In Met Ions Life Sci, 2013
Use of CO as metabolic fuel for microbes relies on enzymes like carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS), which catalyze conversions resembling processes that eventually initiated the dawn of life.CODHs catalyze the (reversible) oxidation of CO with water to CO2 and come in two different flavors with unprecedented active site architectures.
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Impact
Verdin et al., San Francisco, United States. In Cell Metab, 2011
We identified mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 (HMGCS2) as an acetylated protein and a possible target of SIRT3 in a proteomics survey in hepatic mitochondria from Sirt3(-/-) (SIRT3KO) mice.
Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.
Impact
Ashrafi et al., San Francisco, United States. In Cell Metab, 2010
From a C. elegans mutagenesis screen, we found that loss of ACS-3, a long-chain acyl-CoA synthase, causes enhanced intestinal lipid uptake, de novo fat synthesis, and accumulation of enlarged, neutral lipid-rich intestinal depots.
Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production.
Impact
Lam et al., Toronto, Canada. In Nature, 2008
Co-infusion of the acyl-CoA synthase inhibitor triacsin C or the anaesthetic tetracaine with duodenal lipids abolished the inhibition of glucose production, indicating that upper intestinal LCFA-CoAs regulate glucose production in the preabsorptive state.
Enzymes with molecular tunnels.
Review
Impact
Holden et al., College Station, United States. In Acc Chem Res, 2003
Since the first molecular tunnel within tryptophan synthase was discovered in 1988, tunnels within carbamoyl phosphate synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, asparagine synthetase, glutamate synthase, imidazole glycerol phosphate synthase, glucosamine 6-phosphate synthase, and carbon monoxide dehydrogenase/acetyl-CoA synthase have been identified.
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