gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tetraspanin 8

CO-029, TSPAN8, TM4SF3
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, JAZF1, Notch2, CD63, ADAMTS9
Papers on CO-029
Identification of cold responsive genes in Pacific white shrimp (Litopenaeus vannamei) by suppression subtractive hybridization.
New
Chen et al., Nanning, China. In Gene, Feb 2016
The most abundant Est was a tetraspanin-8 (TSPAN8) homolog dubbed LvTSPAN8.
TM4SF3 and AR: A Nuclear Complex that Stabilizes Both Proteins.
New
Shemshedini et al., Toledo, United States. In Mol Endocrinol, Jan 2016
Transmembrane 4 superfamily 3 (TM4SF3) was identified as a novel androgen-regulated gene in prostate cancer (PCa) cells.
Generation of a human antibody that inhibits TSPAN8-mediated invasion of metastatic colorectal cancer cells.
New
Lee et al., Ch'unch'ŏn, South Korea. In Biochem Biophys Res Commun, Jan 2016
Tetraspanin 8 (TSPAN8) is a tumor-associated antigen implicated in tumor progression and metastasis.
Gene expression profiling of prostate cancer-associated genes identifies fibromodulin as potential novel biomarker for prostate cancer.
New
Reyes et al., Cartagena, Colombia. In Int J Biol Markers, Jan 2016
Genes evaluated were ESM-1, SERPINE2, CLU, BGN, A2M, PENK, FMOD, CD81, DCN, TSPAN8, KBTBD10, F2RL1, TMSB4X, SNCG, CXXC5, FOXQ1, PDPN, SPN, CAV1, CD24 and KLK3.
Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.
New
Inoko et al., Yokohama, Japan. In J Hum Genet, Oct 2015
These regions contained the HLA, TSPAN8 and PTPRR genes.
Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype.
Review
New
Yasui et al., Hiroshima, Japan. In Cancer Sci, Aug 2015
Our Serial Analysis of Gene Expression (SAGE) and Escherichia coli ampicillin secretion trap (CAST) analyses revealed that CDH17, REG4, OLFM4, HOXA10, DSC2, TSPAN8 and TM9SF3 are upregulated in GC and that CLDN18 is downregulated in GC.
TSPAN8, identified by Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer.
New
Yasui et al., Hiroshima, Japan. In Gastric Cancer, Mar 2015
Among these genes, TSPAN8 (also known as CO-029 and TM4SF3) gene, which encodes transmembrane protein tetraspanin 8, was emphasized as a candidate.
Association of JAZF1 and TSPAN8/LGR5 variants in relation to type 2 diabetes mellitus in a Saudi population.
Al-Daghri et al., Riyadh, Saudi Arabia. In Diabetol Metab Syndr, 2014
Various genes including zinc finger protein 1 (JAZF1) and tetraspanin 8/leucine-rich repeat-containing G protein-coupled receptor (TSPAN8/LGR5) have been previously described to be associated with T2DM.
TSPAN8 promotes gastric cancer growth and metastasis via ERK MAPK pathway.
Suo et al., Kaifeng, China. In Int J Clin Exp Med, 2014
AIMS: This study was designed to investigate the effects of Tetraspanin 8 (TSPAN8) overexpression and TSPAN8 suppression on gastric cancer cell proliferation and invasion.
The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes.
Yang et al., Beijing, China. In Plos One, 2014
Genetic variants of WFS1, CDKAL1, CDKN2BAS, TCF7L2, HHEX, KCNQ1, TSPAN8/LGR5, FTO, and TCF2 were associated with the risk for T2D with MetS, as well as the risk for development of T2D with at least one of the MetS components (P < 0.05).
Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesions.
GeneRIF
Zhang et al., Memphis, United States. In Plos One, 2011
CO-029 functions as a regulator of both cell-matrix and cell-cell adhesion. During colon cancer progression, CO-029 promotes cancer cell movement by deregulating cell adhesions.
Reduced body weight in male Tspan8-deficient mice.
GeneRIF
Blom et al., Illkirch-Graffenstaden, France. In Int J Obes (lond), 2011
results argue for a role for Tspan8 in body-weight regulation in males, but do not show differences in T2D-associated traits that were anticipated from previous human genome-wide association studies.
Gene expression profiles of human melanoma cells with different invasive potential reveal TSPAN8 as a novel mediator of invasion.
GeneRIF
Lamartine et al., Lyon, France. In Br J Cancer, 2011
High TSPAN8 is associated with melanoma invasiveness.
Activation-induced internalization differs for the tetraspanins CD9 and Tspan8: Impact on tumor cell motility.
GeneRIF
Zoeller et al., Heidelberg, Germany. In Int J Biochem Cell Biol, 2011
PMA-induced Tspan8-internalization promotes cell migration, but reduces matrix and cell adhesion.
Alterations in gene expression in MEN1-associated insulinoma development.
GeneRIF
Hayward et al., Brisbane, Australia. In Pancreas, 2010
Results suggest that alterations in gene expression of Gata6, Tspan8, S100a8, and Lmo2 may act via novel pathways that play functionally important roles in Men1-associated tumor progression.
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.
Impact
Donnelly et al., In Nature, 2010
Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies.
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Impact
Altshuler et al., Oxford, United Kingdom. In Nat Genet, 2008
We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions.
The tumor antigen EpCAM: tetraspanins and the tight junction protein claudin-7, new partners, new functions.
Review
Zoller et al., Villejuif, France. In Front Biosci, 2007
EpCAM can associate with claudin-7 and the tetraspanins CD9 and CO-029.
Gastrointestinal tumors: metastasis and tetraspanins.
Review
Zöller, Heidelberg, Germany. In Z Gastroenterol, 2006
Notably, some members of this family, in particular, CD82/KAI1 are known as metastasis suppressor genes, while others like CD151 and CO-029 are supposed to promote metastasis formation.
Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63.
Review
Vlcek et al., Praha, Czech Republic. In Febs Lett, 1991
Several of the recently described leucocyte surface (glyco)-proteins with significant amino acid sequence similarity (human CD9, CD37, CD53, CD63, TAPA-1, CO-029 and R2 and several homologues of other species) are distinguished by the polypeptide chain apparently four times crossing the membrane.
share on facebooktweetadd +1mail to friends