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Solute carrier family 28

CNT2, hCNT2, SLC28A2, rCNT2, concentrative nucleoside transporter 2, SPNT
regulates adenosine transport across the blood-brain barrierinto the brain [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Equilibrative Nucleoside Transporter 1, HAD, ACID, V1a, POLYMERASE
Papers on CNT2
Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization.
Hijazi et al., Bethlehem, United States. In J Antimicrob Chemother, Feb 2016
RESULTS: Expression of 58 of the 84 transporters was documented in colorectal biopsies, with genes for CNT2, P-glycoprotein (P-gp) and MRP3 showing the highest expression.
Clinical pharmacology of tenofovir clearance: a pharmacokinetic/pharmacogenetic study on plasma and urines.
Bonora et al., Torino, Italy. In Pharmacogenomics J, Nov 2015
At multivariate analysis estimated creatinine clearance, protease inhibitors co-administration and SLC28A2 CT/TT genotypes were independently associated with plasma tenofovir exposure; ABCC10 GA/AA genotypes and protease inhibitor co-administration were independently associated with the urinary to plasma tenofovir ratio.
Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment.
Romero-Gómez et al., Sevilla, Spain. In J Clin Virol, Jul 2015
AIM: To assess the pharmacogenomic impact of candidate genes SLC28A2, SLC28A3 and ITPA on anaemia in patients receiving triple therapy.
Intracellular accumulation of boceprevir according to plasma concentrations and pharmacogenetics.
D'Avolio et al., Torino, Italy. In Int J Antimicrob Agents, Jun 2015
ABCB1 1236, SLC28A2 124 and IL28B rs12979860 SNPs were associated with the S isomer PBMC/plasma concentration ratio.
Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors.
Shuto et al., Hotaka, Japan. In Acs Med Chem Lett, Apr 2015
We hypothesized that inhibition of human concentrative nucleoside transporter 2 (hCNT2) would suppress increases in serum urate levels derived from dietary purines.
Role of pharmacogenetic in ribavirin outcome prediction and pharmacokinetics in an Italian cohort of HCV-1 and 4 patients.
D'Avolio et al., Torino, Italy. In Biomed Pharmacother, Feb 2015
Ribavirin is phosphorylated by adenosine kinase 1 (AK1) and cytosolic 5'-nucleotidase 2 and it is transported into cells by concentrative nucleoside transporters (CNT) 2/3, coded by SLC28A2/3 genes, and equilibrative nucleoside transporters (ENT) 1/2, coded by SLC29A1/2 genes.
ABCB11 and ABCB1 gene polymorphisms impact on telaprevir pharmacokinetic at one month of therapy.
D'Avolio et al., Torino, Italy. In Biomed Pharmacother, Feb 2015
The aim of this retrospective study was the evaluation of the influence of some single nucleotide polymorphisms (SNPs) of genes (ABCB1, SLC28A2/3, SLC29A1) involved in TLV and RBV transport and their correlation with plasma TLV drug exposure at 1 month of therapy.
Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug-Drug Interactions.
Trejtnar et al., Hradec Králové, Czech Republic. In Front Pharmacol, 2014
The goal of this study was to investigate the potential of ETV to interact in vitro with the renal SLC transporters hOAT1, hOCT2, hCNT2 and hCNT3.
Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets.
Pérez-Torras et al., Barcelona, Spain. In Front Pharmacol, 2014
The former encodes hCNT1, hCNT2, and hCNT3 proteins.
Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia patients.
Picard et al., Asyūţ, Egypt. In Pharmacogenomics, 2014
RESULTS: We found significant associations between ITPA, IMPDH1, SLC29A1, SLC28A2, SLC28A3 and ABCC4 SNPs and one or more of the hematological toxicity manifestations (neutropenia, agranulocytosis and leukopenia); age was significantly related to relapse.
rCNT2 extracellular cysteines, Cys(615) and Cys(649), are important for maturation and sorting to the plasma membrane.
Pastor-Anglada et al., Barcelona, Spain. In Febs Lett, 2014
rCNT2 is a purine-preferring concentrative nucleoside transporter implicated in the regulation of extracellular adenosine levels and purinergic signaling.
Methodological limitations in determining astrocytic gene expression.
Wang et al., Shenyang, China. In Front Endocrinol (lausanne), 2012
The same applies to the concentrative transporters CNT2 and CNT3.
Structural determinants for rCNT2 sorting to the plasma membrane of polarized and non-polarized cells.
Pastor-Anglada et al., Barcelona, Spain. In Biochem J, 2012
the N-terminal tail of rCNT2 contains dual sorting signals. An acidic region is responsible for its proper stabilization at the plasma membrane, whereas the putative CK2 domain (Ser(46)) is implicated in the apical sorting of the transporter.
Link between high-affinity adenosine concentrative nucleoside transporter-2 (CNT2) and energy metabolism in intestinal and liver parenchymal cells.
Pastor-Anglada et al., Barcelona, Spain. In J Cell Physiol, 2010
These findings support the theory that CNT2 plays roles other than salvage and establishes links with energy metabolism.
Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes.
Chiba et al., Chiba, Japan. In Antimicrob Agents Chemother, 2010
Data concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes.
Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).
Giacomini et al., San Francisco, United States. In J Pharmacol Exp Ther, 2009
Single nucleotide polymorphisms of this protein may play a role in variation in the pharmacokinetics and pharmacological effects of nucleoside analogs.
Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.
Unadkat et al., Seattle, United States. In Am J Physiol Gastrointest Liver Physiol, 2008
Report expression and hepatobiliary transport characteristics of CNT2 in sandwich-cultured human hepatocytes.
SLC28 genes and concentrative nucleoside transporter (CNT) proteins.
Casado et al., Barcelona, Spain. In Xenobiotica, 2008
hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner.
Concentrative nucleoside transporters (CNTs) in epithelia: from absorption to cell signaling.
Casado et al., Barcelona, Spain. In J Physiol Biochem, 2007
CNT expression (particularly CNT2) is associated with differentiation and is also nutritionally regulated in intestinal epithelia, whereas ENT protein amounts (mostly ENT1) are increased when cells are exposed to proliferative stimuli such as EGF, TGF-alpha or wounding.
Renal nucleoside transporters: physiological and clinical implications.
Cass et al., Edmonton, Canada. In Biochem Cell Biol, 2006
The 7 known human NTs (hNTs) exhibit varying permeant selectivities and are divided into 2 protein families: the solute carrier (SLC) 29 (SLC29A1, SLC29A2, SLC29A3, SLC29A4) and SLC28 (SLC28A1, SLC28A2, SLC28A3) proteins, otherwise known, respectively, as the human equilibrative NTs (hENTs, hENT1, hENT2, hENT3, hENT4) and human concentrative NTs (hCNTs, hCNT1, hCNT2, hCNT3).
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