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Protocadherin alpha 10

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, ACID, RAR, RARgamma
Papers on CNR8
Steroid/thyroid hormone receptor genes in Caenorhabditis elegans.
Rall et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 1995
CNR8 shows homology to NAK1, and CNR14 has homology to both the RAR-gamma 1 gene and to another ecdysone response gene, E78A.
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