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Protein phosphatase 3, regulatory subunit B, alpha

CNB, Cnb1, PPP3R1
regulatory subunit of the enzyme that catalyzes the calcium-dependent removal of serine- and threonine-bound phosphate groups [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, CNA, HAD, ACID, erbB-2
Papers on CNB
Construction of tissue microarrays from core needle biopsies - a systematic literature review.
Cheung et al., Nottingham, United Kingdom. In Histopathology, Feb 2016
In some clinical circumstances, core needle biopsy (CNB) may be the only source of material from cancer tissue for diagnostic use.
Structural Basis of Cyclic Nucleotide Selectivity in cGMP-Dependent Protein Kinase II.
Kim et al., United States. In J Biol Chem, Feb 2016
Here, we find that the C-terminal cyclic nucleotide binding (CNB-B) domain of PKG II binds cGMP with higher affinity and selectivity, compared to its N-terminal CNB (CNB-A) domain.
Reflex Repeat HER2 Testing of Grade 3 Breast Carcinoma at Excision Using Immunohistochemistry and In Situ Analysis:  Frequency of HER2 Discordance and Utility of Core Needle Biopsy Parameters to Refine Case Selection.
Browne et al., Cork, Ireland. In Am J Clin Pathol, Jan 2016
All discordant cases showed equivocal IHC on core needle biopsy (CNB) specimens and/or tumor upgrade at excision.
Impact of host and histopathological factors on the discrepancies in estrogen receptor, and progesterone receptor, and HER2 status between core needle biopsy and surgically excised tumors.
Miyazaki et al., Chiba, Japan. In Breast, Jan 2016
PURPOSE: The high reliability and utility of core needle biopsy (CNB) have been previously described.
Calcineurin Links Mitochondrial Elongation with Energy Metabolism.
Tschöp et al., München, Germany. In Cell Metab, Dec 2015
In mice, global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity and comorbid sequelæ.
[Role of calcineurin-nuclear factor of activated T cells signaling pathway in myoblast apoptosis induced by cyclic tensile strain].
Yuan et al., In Hua Xi Kou Qiang Yi Xue Za Zhi, Oct 2015
The mRNA expression of the CaN subunits, CnA and CnB, and the protein levels of NFAT3 also increased.
Intramuscular high-grade myxofibrosarcoma of left buttock of 66-year-old male patient - approach to systematic histopathological reporting.
Sulkowski et al., Kielce, Poland. In Rom J Morphol Embryol, 2014
The tumor was biopsied with fine-needle aspiration (FNA) and core-needle biopsy (CNB) and then the whole myxoid tumor was excised with left musculus gluteus maximus.
Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts.
Gonzalez et al., Barcelona, Spain. In Nat Cell Biol, 2013
During interphase in Drosophila neuroblasts, the Centrobin (CNB)-positive daughter centriole retains pericentriolar material (PCM) and organizes an aster that is a key determinant of the orientation of cell division.
Preoperative systemic therapy in locoregional management of early breast cancer: highlights from the Kyoto Breast Cancer Consensus Conference.
Inamoto et al., Kyoto, Japan. In Breast Cancer Res Treat, 2012
In addition, axillary diagnosis with ultrasound and concomitant fine needle aspiration cytology or core needle biopsy (CNB) was reported to contribute to the construction of a treatment algorithm for patient-specific or individualized axillary surgery.
Assessment accuracy of core needle biopsy for hormone receptors in breast cancer: a meta-analysis.
Jiang et al., Chongqing, China. In Breast Cancer Res Treat, 2012
The concordance of hormone receptors (HR) status identified by core needle biopsy (CNB) compared with excisional biopsy (EB) has been widely reported, but results were extremely variable and underpowered.
Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.
Kim et al., Stanford, United States. In Dev Cell, 2012
Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion.
The calcineurin B subunit induces TNF-related apoptosis-inducing ligand (TRAIL) expression via CD11b-NF-κB pathway in RAW264.7 macrophages.
Wei et al., Beijing, China. In Biochem Biophys Res Commun, 2012
These findings reveal a novel signaling pathway (CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity.
Calcineurin subunit B is an immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection.
Wei et al., Beijing, China. In Immunol Lett, 2011
immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection
Mutation of calcineurin subunit B M118 influences the activities of NF-AT and p53, but not calcineurin expression level.
Wei et al., Beijing, China. In Biochem Biophys Res Commun, 2011
CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells.
Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in Th cells.
Baumgrass et al., Berlin, Germany. In Eur J Immunol, 2011
Findings demonstrate that CaN functions as a critical signaling molecule during Th cell activation, regulating Bcl-10 phosphorylation and NF-kappaB activation.
Core needle biopsy versus fine needle aspiration biopsy in breast--a historical perspective and opportunities in the modern era.
Nassar, Rochester, United States. In Diagn Cytopathol, 2011
Breast fine-needle aspiration biopsy (FNAB) by palpation is on the decline, due to its limitations in diagnostic accuracy, decreased sensitivity, and its replacement with core needle biopsy (CNB).
Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective.
Lapchak, Los Angeles, United States. In Expert Opin Investig Drugs, 2011
The novel multi-target curcuminoid, CNB-001, has a superior safety and pharmacokinetic profile and should be further developed as an acute monotherapy or to be used in conjunction with thrombolytics for acute ischemic stroke.
Reliability of human epidermal growth factor receptor 2 immunohistochemistry in breast core needle biopsies.
Untch et al., Hamburg, Germany. In J Clin Oncol, 2010
IHC was false negative in one CNB only.
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.
Crabtree et al., Stanford, United States. In Cell, 2001
Since calcineurin is thought to control nuclear localization of NFATc proteins, we introduced a mutation into the calcineurin B gene that prevents phosphatase activation by Ca(2+) signals.
The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation.
McKeon et al., Boston, United States. In Cell, 1994
We have created calcineurins that are resistant to both cyclosporin A and FK506 by mutating specific residues in CnB, a calcium-binding protein that regulates the catalytic subunit, CnA.
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