Targeting Signaling Transduction Pathways in Bladder Cancer.
Philadelphia, United States. In Curr Oncol Rep, Dec 2015
Simultaneously, a rationale for such therapies has come to the forefront of management of this disease because an overabundance of signaling pathways are genetically deranged as a result of point mutation or copy number alteration (CNA) as identified by several recent next generation sequencing (NGS) studies.
Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
Taipei, Taiwan. In World J Gastroenterol, 2014
Because a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain, copy number alteration (CNA) analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons, homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC progression.
Calcineurin: a poorly understood regulator of muscle mass.
Atlanta, United States. In Int J Biochem Cell Biol, 2013
This review will discuss the existing literature that has examined the role of calcineurin (CnA) in the regulation of skeletal muscle mass in conditions associated with hypertrophic growth or atrophy.