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5'-nucleotidase, cytosolic II

cN-II, purine 5'-nucleotidase, cytosolic purine 5'-nucleotidase
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, deoxycytidine kinase, ACID, UGT1A1
Papers on cN-II
Microsurgical resectability, outcomes, and tumor control in meningiomas occupying the cavernous sinus.
New
Missios et al., Buffalo, United States. In J Neurosurg, Feb 2016
CN II deficits were most common.
Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
New
Chaloin et al., Montpellier, France. In J Med Chem, Jan 2016
We used a combined approach based on fragment-based drug design (FBDD) and in silico methods to design potential inhibitors of the cytosolic 5'-nucleotidase II (cN-II), which has been recognized as an important therapeutic target in hematological cancers.
The druggability of intracellular nucleotide-degrading enzymes.
Review
New
Jordheim et al., Padova, Italy. In Cancer Chemother Pharmacol, Dec 2015
We review scientific findings that over the last 10-15 years have allowed the identification of several intracellular nucleotide-degrading enzymes as cancer drug targets, and discuss further potential therapeutic applications for Rcl, SAMHD1, MTH1 and cN-II.
Anatomical Sciences Education Vol. 8, Issue 6, 2015 Cover Image.
New
In Anat Sci Educ, Dec 2015
In this issue of ASE, Kerry Dickson and Bruce Stephens describe these actions (for example, CN II: hands forming tunnels in front of the eyes to represent vision) and the effect of their use on student performance.
Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells.
New
Nikiforov et al., Saint Petersburg, Russia. In J Biol Chem, Dec 2015
We demonstrate that purified, recombinant human cytosolic 5'-nucleotidases (5'-NTs) CN-II and CN-III, but not CN-IA, can dephosphorylate the mononucleotides nicotinamide mononucleotide and nicotinic acid mononucleotide (NAMN) and thus catalyze NR and NAR formation in vitro.
The fate of cranial neuropathy after flow diversion for carotid aneurysms.
New
Hanel et al., San Juan, Puerto Rico. In J Neurosurg, Nov 2015
At last follow-up, 60% of patients in the isolated CN II group had improvement, while in the CN III, IV, or VI group, 85.7% had improved.
Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.
New
Tozzi et al., Pisa, Italy. In Int J Biochem Cell Biol, Aug 2015
Cytosolic 5'-nucleotidase II (cN-II) has been reported to be involved in cell survival, nucleotide metabolism and in the cellular response to anticancer drugs.
IMP-GMP specific cytosolic 5'-nucleotidase regulates nucleotide pool and prodrug metabolism.
New
Tozzi et al., Pisa, Italy. In Biochim Biophys Acta, Jul 2015
BACKGROUND: Type II cytosolic 5'-nucleotidase (cN-II) catalyzes the hydrolysis of purine and, to some extent, of pyrimidine monophosphates.
Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.
New
Dumontet et al., Lyon, France. In Anal Bioanal Chem, Jul 2015
The cytosolic 5'-nucleotidase (cN-II) has been shown to be involved in the response of cancer cells to cytotoxic agents, and the quantification of its activity in biological samples is of great interest.
Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf.
Allegrini et al., Pisa, Italy. In Plos One, 2014
IMP/GMP preferring cytosolic 5'-nucleotidase II (cN-II) is a bifunctional enzyme whose activities and expression play crucial roles in nucleotide pool maintenance, nucleotide-dependent pathways and programmed cell death.
Cavernous malformations isolated from cranial nerves: Unexpected diagnosis?
Review
Scuotto et al., Napoli, Italy. In Clin Neurol Neurosurg, 2014
CMs affecting the optic nerve (CN II), oculomotor nerve (CN III), facial/vestibule-cochlear nerves (CN VII, CN VIII) have been described.
Is the expression of deoxynucleoside kinases and 5'-nucleotidases in animal tissues related to the biological effects of nucleoside analogs?
Review
Eriksson, Uppsala, Sweden. In Curr Med Chem, 2012
In this chapter the expression patterns of the four dNKs i.e.cytosolic deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1) and the mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) as well as the six intracellular 5'-NTs: cN-IA, cN-IB, cN-II, cN-III, cdN, mdN, present in animal cells and tissues will be described.
The functional logic of cytosolic 5'-nucleotidases.
Review
Balestri et al., Pisa, Italy. In Curr Med Chem, 2012
Intracellular balance of nucleosides is maintained by the action of several enzymes, such as adenosine deaminase, uridine phosphorylase and cytidine deaminase, and by at least three 5'-nucleotidases, the ADP activated AMP preferring cN-IA, the ATP-ADP activated IMP-GMP preferring cN-II, and the UMP-CMP preferring cN-III.
Enzymatic properties and physiological roles of cytosolic 5'-nucleotidase II.
Review
Itoh, Japan. In Curr Med Chem, 2012
Cytosolic 5'-nucleotidase II (cN-II) is an intracellular 5'-nucleotidase characterized by substrate specificity.
Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women.
GeneRIF
Sekine et al., Kyoto, Japan. In J Hum Genet, 2012
Polymorphisms in the CYP17A1 and NT5C2 genes influence a reduction in both visceral and subcutaneous fat mass in Japanese women.
Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II.
GeneRIF
Nordlund et al., Stockholm, Sweden. In J Mol Biol, 2011
seven high-resolution structures of human cN-II, including a ligand-free form and complexes with various substrates and effectors, were presented.
Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells.
GeneRIF
Ueda et al., Fukui, Japan. In Biochem Pharmacol, 2009
The DCK/cN-II ratio was again proportional to ara-CTP production and to ara-C sensitivity.
Differential allelic expression in leukoblast from patients with acute myeloid leukemia suggests genetic regulation of CDA, DCK, NT5C2, NT5C3, and TP53.
GeneRIF
Tavtigian et al., Lyon, France. In Drug Metab Dispos, 2008
In leukoblasts from 82 patients with acute myeloid leukemia, various extent and frequency of differential allelic expression in the CDA, DCK, NT5C2, NT5C3, and TP53 genes was observed.
Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition.
GeneRIF
Nordlund et al., Stockholm, Sweden. In J Biol Chem, 2007
Data describe the crystal structure of human cytosolic 5'-nucleotidase II and discuss its allosteric regulation and substrate recognition.
Lymphocyte purine 5'-nucleotidase edficiency in primary hypogammaglobulinaemia.
Impact
Webster et al., In Lancet, 1977
The mean activity of purine 5'-nucleotidase (E.C.3.1.3.5) in lymphocytes was significantly lower in patients with non-familial adult onset "variable" primary hypogammaglobulinaemia than in non-hypogammaglobulinaemic control subjects.
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