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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CKLF-like MARVEL transmembrane domain containing 5

CMTM5
This gene belongs to the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, V1a, POLYMERASE
Papers on CMTM5
[Association between CMTM5 gene rs723840 single nucleotide polymorphism and high on asprin platelet reactivity].
New
Liu et al., Beijing, China. In Beijing Da Xue Xue Bao, Jan 2016
OBJECTIVE: To elucidate the correlation between the single nucleotide polymorphism of CKLF-like MARVEL transmembrane member 5 (CMTM5) gene rs723840 and the occurrence of high on aspirin platelet reactivity (HAPR).
[Expression and significance of CMTM5 and epidermal growth factor receptor in prostate cancer].
New
Wang et al., Shenzhen, China. In Beijing Da Xue Xue Bao, Sep 2015
OBJECTIVE: To investigate the expression patterns of CKLF-like MARVEL transmembrane domain containing 5 (CMTM5), a novel tumor suppressor, and epidermal growth factor receptor (EGFR) in prostate cancer (PCa) tissues and cells and to analyze the relationship between CMTM5 and EGFR in PCa.
CMTM5 is reduced in prostate cancer and inhibits cancer cell growth in vitro and in vivo.
New
Wang et al., Beijing, China. In Clin Transl Oncol, Jun 2015
PURPOSE: A novel tumor suppressor CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) is reduced or undetectable in many kinds of cancers and inhibits tumor cells' malignant features.
CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma.
Li et al., Beijing, China. In Biochem Biophys Res Commun, 2014
CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) has been recently implicated as a tumor suppressor gene in several cancer types.
[Research advances in CKLF-like MARVEL transmembrane domain containing member 5].
Review
Wang et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2012
CMTM5 belongs to this family and has exhibited tumor-inhibiting activities.
[Inhibitory effect of CMTM5 on xenografted human prostatic cancer in nude mice].
Wang et al., Beijing, China. In Zhonghua Nan Ke Xue, 2012
OBJECTIVE: To investigate the inhibitory effect of CKLF-like MARVEL transmembrane domain containing 5 (CMTM5) on xenografted human prostatic cancer in nude mice and its action mechanism.
Reduced CMTM5 expression correlates with carcinogenesis in human epithelial ovarian cancer.
GeneRIF
Kong et al., Jinan, China. In Int J Gynecol Cancer, 2011
The reduced expression of CMTM5 correlates significantly with poorly differentiated ovarian cancer and high preoperative CA125 level.
Aberrant expression of CKLF-like MARVEL transmembrane member 5 (CMTM5) by promoter methylation in myeloid leukemia.
GeneRIF
Ruan et al., Beijing, China. In Leuk Res, 2011
Data suggest that CMTM5 may be involved in the pathomechanism of myeloid leukemias.
[CMTM5 inhibits the tumor cell behavior of prostate cancer by downregulation of HER2].
GeneRIF
Wang et al., Beijing, China. In Beijing Da Xue Xue Bao, 2010
HER2 was up regulated in prostate cancer epithelium while CMTM5 was down regulated. Overexpression of CMTM5 in PC3 cells could lower the HER2 and Cyclin D1 protein level.
[Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats].
Chen et al., Beijing, China. In Yao Xue Xue Bao, 2010
Testosterone did not influence the expression of CKLF1, CMTM3 and CMTM5, the CMTM6, CMTM7 and CMTM8 of CMTM family were not detected in testis tissue.
[Abnormally lower expression of cmtm5 gene in bone marrow cells from patients with multiple myeloma].
GeneRIF
Ruan et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
The expression level of cmtm5 gene is abnormally lower in the bone marrow cells from the multiple myeloma patients, and are associated with ISS stages.
The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines.
Chan et al., Hong Kong, Hong Kong. In Invest New Drugs, 2010
Exposure to PXD101 for up to 48 h had varying effects on the expression of 12 cellular genes with tumor suppressor functions, including p21, SOCS1, CMTM5, RASAL1, DLEC1, SFRP (-1, -2, -4 and -5), ADAMTS (-8 and -9).
CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway.
GeneRIF
Han et al., Beijing, China. In Bmb Rep, 2010
CMTM5-v1 might be secreted via a different vesicle-mediated secretory pathway, which will be helpful for the studies of vesicle-mediated secretion and MARVEL domain-containing proteins.
CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha.
GeneRIF
Han et al., Beijing, China. In Biochem Biophys Res Commun, 2009
CMTM5 may play a role in the pancreatic cancer.
CMTM5-v1 induces apoptosis in cervical carcinoma cells.
GeneRIF
Han et al., Beijing, China. In Biochem Biophys Res Commun, 2009
These findings verify that CMTM5-v1 inhibits the growth of CC cell lines via inducing apoptosis.
CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines.
GeneRIF
Tao et al., Beijing, China. In Clin Cancer Res, 2007
CMTM5 exhibits tumor suppressor activities, but with frequent epigenetic inactivation in carcinoma cell lines
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