Interaction of human genes WT1 and CML28 in leukemic cells.
Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 2013
Earlier studies have shown both Wilms' tumor 1 suppressor gene (WT1) and CML28 abnormally expressed in malignant diseases of the hematopoietic system and WT1 played an important role in leukemogenesis.
[In vitro cytotoxic effects of CML28 specific T cells on acute leukemia cells].
Wuhan, China. In Zhonghua Xue Ye Xue Za Zhi, 2009
METHODS: aAPCs were developed by coating a human leukocyte antigen-immunoglobulin fusion protein ( HLA-lg), which was connected each one of the four CML28 antigen epitopes (DLMSSTKGL, DLMSSTKGL, ALFCGVACA, VLTFALDSV), and CD28-specific antibody, to magnet-beads CML cell specific peptides (CML28) served as target peptides.
[Activation of specific T lymphocyte induced by artificial antigen presenting cell complex in vitro].
Wuhan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2008
The specific antigen of chronic myeloid leukemia CML-28 was screened as objective antigen peptide by using magnetic microbeads as vector; the CML-28 epitope sequence (Vltfaldsv) was obtained by antigen epitope prediction software; this epitope was coupled with MHC molecule and used as first signal molecule, the B7-1 molecule was used as second signal molecule; these 2 molecules simultaneously were loaded onto surface of magnetic microbeads so as to contract aAPC complex.