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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Chemokine-like receptor 1

CMKLR1, ChemR23, chemokine-like receptor 1
Top mentioned proteins: Chemerin, CAN, ACID, Insulin, V1a
Papers on CMKLR1
Pro- and Anti-Inflammatory Role of ChemR23 Signaling in Pollutant-Induced Inflammatory Lung Responses.
Joos et al., Gent, Belgium. In J Immunol, Feb 2016
Monocytes and immature DCs express the G-protein coupled receptor chemR23, which binds the chemoattractant chemerin.
CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway.
Sinal et al., Halifax, Canada. In Mol Cell Endocrinol, Jan 2016
To date, all known chemerin functions have been attributed to activation of the G protein-coupled receptor chemokine-like receptor-1 (CMKLR1).
Inflammation activation and resolution in human tendon disease.
Carr et al., Oxford, United Kingdom. In Sci Transl Med, Nov 2015
The proresolving proteins FPR2/ALX and ChemR23 were increased in early-stage disease compared to intermediate- to advanced-stage disease.
Chemerin is a novel regulator of lactogenesis in bovine mammary epithelial cells.
Roh et al., Sendai, Japan. In Biochem Biophys Res Commun, Nov 2015
Two types of chemerin receptors, chemokine like-receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2), were detected in cultured MAC-T cells, whereas chemerin was not detected.
Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure.
Yamawaki et al., Aomori, Japan. In Am J Physiol Heart Circ Physiol, Sep 2015
Various inhibitors (ROS inhibitor: N-acetyl-l-cysteine, phosphatidylinositol 3-kinase inhibitor: LY-294002, MAPKK inhibitor: PD-98059, NADPH oxidase inhibitor: gp91 ds-tat, and xanthine oxidase inhibitor: allopurinol) as well as chemokine-like receptor 1 small interfering RNA significantly inhibited chemerin-induced SMC proliferation and migration.
Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis.
Sinal et al., Halifax, Canada. In Physiol Rep, Aug 2015
In the current study, we demonstrate that expression, secretion, and processing of chemerin, a potent chemoattractant for cells expressing chemokine-like receptor 1 (CMKLR1), increased in the cecum and colon along a gradient positively associated with the severity of inflammation in dextran sodium sulfate (DSS)-induced colitis.
Chemerin/chemR23 axis in inflammation onset and resolution.
Roncucci et al., Modena, Italy. In Inflamm Res, Feb 2015
Chemerin binds to three receptors, especially to chemR23, expressed on various cells, as dendritic cells, macrophages and natural killer cells, regulating chemotaxis towards the site of inflammation and activation status.
Microglial Aβ receptors in Alzheimer's disease.
Ye et al., Shanghai, China. In Cell Mol Neurobiol, 2015
The G protein-coupled receptors (GPCRs) are formyl peptide receptor 2 (FPR2) and chemokine-like receptor 1 (CMKLR1).
Expression of adiponectin, chemerin and visfatin in plasma and different tissues during a laying season in turkeys.
Dupont et al., France. In Reprod Biol Endocrinol, 2014
Visf receptor is still unknown whereas ADP and Chem mainly act through AdipoR1, AdipoR2 and CMKLR1 and GPR1 receptors, respectively.
Chemerin15-Ameliorated Cardiac Ischemia-Reperfusion Injury Is Associated with the Induction of Alternatively Activated Macrophages.
Zhou et al., Beijing, China. In Mediators Inflamm, 2014
Chemerin15 (C15), an endogenous anti-inflammatory component, inhibits the activity of neutrophils and macrophages through G protein-coupled receptor ChemR23; however, its role as well as functional mechanism in mouse myocardial ischemia/reperfusion (I/R) injury remains unknown.
The Adipokine Chemerin Induces Apoptosis in Cardiomyocytes.
Lago et al., Santiago de Compostela, Spain. In Cell Physiol Biochem, 2014
Finally, RT-qPCR, ELISA and western blot were performed to examine chemerin and CMKLR1 expression after insulin and TNF-α treatment in cardiac cells.
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.
Rovati et al., Stockholm, Sweden. In Br J Pharmacol, 2014
Finally, lipoxygenase metabolites derived from ω-3 essential polyunsaturated acids, the resolvins, activate the receptors GPR32 and ChemR23.
Processing, signaling, and physiological function of chemerin.
Beck-Sickinger et al., Leipzig, Germany. In Iubmb Life, 2014
Processed by a variety of proteases linked to inflammation, it activates the G-protein coupled receptor chemokine-like receptor 1 (CMKLR1) and induces chemotaxis in natural killer cells, macrophages, and immature dendritic cells.
Natural resolution of inflammation.
Van Dyke et al., In Periodontol 2000, 2013
G protein-coupled receptor 32, lipoxin A4 receptor/formyl peptide receptor2, chemokine-like receptor 1, leukotriene B4 receptor type 1 and cabannoid receptor 2) induces cessation of leukocyte infiltration; vascular permeability/edema returns to normal with polymorphonuclear neutrophil death (mostly via apoptosis), the nonphlogistic infiltration of monocyte/macrophages and the removal (by macrophages) of apoptotic polymorphonuclear neutrophils, foreign agents (bacteria) and necrotic debris from the site.
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
Harmar et al., Cambridge, United Kingdom. In Pharmacol Rev, 2013
The following recommendations are made for new receptor names based on 11 pairings for class A GPCRs: hydroxycarboxylic acid receptors [HCA₁ (GPR81) with lactate, HCA₂ (GPR109A) with 3-hydroxybutyric acid, HCA₃ (GPR109B) with 3-hydroxyoctanoic acid]; lysophosphatidic acid receptors [LPA₄ (GPR23), LPA₅ (GPR92), LPA₆ (P2Y5)]; free fatty acid receptors [FFA4 (GPR120) with omega-3 fatty acids]; chemerin receptor (CMKLR1; ChemR23) with chemerin; CXCR7 (CMKOR1) with chemokines CXCL12 (SDF-1) and CXCL11 (ITAC); succinate receptor (SUCNR1) with succinate; and oxoglutarate receptor [OXGR1 with 2-oxoglutarate].
Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis.
Goralski et al., Halifax, Canada. In Am J Physiol Cell Physiol, 2012
the results of this study reveal a novel involvement for CMKLR1 in myogenic differentiation in vitro and suggest an important role for CMKLR1 in proper muscle development in vivo.
Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.
Sinal et al., Halifax, Canada. In Endocrinology, 2012
Collectively these data provide compelling evidence that CMKLR1 influences adipose tissue development, inflammation, and glucose homeostasis and may contribute to the metabolic derangement characteristic of obesity and obesity-related diseases.
ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia.
Parmentier et al., Brussels, Belgium. In Plos Pathog, 2011
ChemR23-dependent recruitment of plasmacytoid dendritic cells contributes to adaptive immune responses and viral clearance, and also enhances the inflammatory response;the chemerin/ChemR23 system plays important roles in the physiopathology of viral pneumonia
Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins.
Cichy et al., Kraków, Poland. In J Immunol, 2011
Chemerin, a ligand for the G-protein coupled receptor chemokine-like receptor 1, requires carboxy-terminal proteolytic processing to unleash its chemoattractant activity
Expression of chemokine-like receptor 1 (CMKLR1) on J744A.1 macrophages co-cultured with fibroblast and/or tumor cells: modeling the influence of microenvironment.
Guc et al., Ankara, Turkey. In Cell Immunol, 2010
Data suggest may a potential role for chemerin and CMKLR1 in the regulation of inflammatory responses in the tumor microenvironment.
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