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Ribosomal protein S6 kinase, 90kDa, polypeptide 3

CLS, CLSI, RSK, RSK2, RSK1, calpain I
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ERK, HAD, V1a, ACID
Papers using CLS antibodies
TOR signaling in growth and metabolism
Supplier
Patel Tarun B. et al., In Oncogene, 2005
... Anti-phospho-RSK1 (Ser-380) (Epitomics, Burlingame, CA), anti-Erk1/2 (Upstate ...
Papers on CLS
Phenotypic, genotypic, and antimicrobial characteristics of Streptococcus halichoeri isolated from humans and proposal to rename Streptococcus halichoeri as Streptococcus halichoeri subsp. halichoeri and description of Streptococcus halichoeri subsp. hominis subsp. nov., a bacterium associated with human clinical infections.
New
Humrighouse et al., Atlanta, United States. In J Clin Microbiol, Feb 2016
S. halichoeri(T) and the human clinical isolates were susceptible to the antimicrobials tested based on CLSI guidelines for Streptococcus species viridans group with the exception of tetracycline and erythromycin.
Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells.
New
Servais et al., Tours, France. In Biochim Biophys Acta, Feb 2016
For this purpose, we generated a cardiolipin synthase knockdown (shCLS) in HepaRG hepatoma cells showing bioenergetics features similar to primary human hepatocytes.
Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease.
New
Kimab et al., Wŏnju, South Korea. In Peptides, Feb 2016
We show here that L-ENK induced activation of Erk, P90(RSK), and Elk-1 and promoted the disruption of hemidesmosomes and the expression of matrix metalloprotease (MMP)-2 and MMP-9, important processes for wound healing.
First description of SHV-148 mediated extended-spectrum cephalosporin resistance among clinical isolates of Escherichia coli from India.
New
Bhattacharjee et al., Silchar, India. In Indian J Med Microbiol, Jan 2016
METHODOLOGY: Phenotypic characterisation of extended-spectrum beta-lactamases (ESBLs) was carried out as per CLSI criteria.
Vertebrate Reproduction.
Review
New
Fissore et al., Durham, United States. In Cold Spring Harb Perspect Biol, Oct 2015
Protein kinase and phosphatase signaling pathways involving Mos, CDK1, RSK, and PP2A regulate meiosis during maturation of the oocyte.
DNA damage control: regulation and functions of checkpoint kinase 1.
Review
New
Gillespie et al., Santa Cruz de Tenerife, Spain. In Febs J, Oct 2015
Additional modifications catalysed by other protein kinases, such as cyclin-dependent kinase 1, Akt, and RSK, can combine with ubiquitylation to regulate Chk1 subcellular localization and protein stability.
Molecular Targeting of ERKs/RSK2 Signaling Axis in Cancer Prevention.
Review
New
Cho et al., Puch'ŏn, South Korea. In J Cancer Prev, Sep 2015
For this reason, RSK2 is a highly conserved protein among the p90RSK family members.
Kinetochore components are required for central spindle assembly.
New
Impact
Dumont et al., Paris, France. In Nat Cell Biol, May 2015
Specifically, central spindle microtubule assembly is dependent on kinetochore recruitment of the scaffold protein KNL-1, as well as downstream partners BUB-1, HCP-1/2(CENP-F) and CLS-2(CLASP); and is negatively regulated by kinetochore-associated protein phosphatase 1 activity.
RSK3: A regulator of pathological cardiac remodeling.
Review
New
Kapiloff et al., Miami, United States. In Iubmb Life, May 2015
Although RSK3 is less abundant in the cardiac myocyte than other RSK family members, RSK3 appears to serve a unique role in cardiac myocyte stress responses.
Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.
Impact
Wiest et al., Philadelphia, United States. In Immunity, 2015
While ERK phosphorylates most substrates, such as RSK, by targeting them through its D-domain, this well-studied mode of ERK action was dispensable for development of γδ T cells.
MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges.
Review
Gaestel, Hannover, Germany. In Front Cell Dev Biol, 2014
This short review will summarize recent developments including the linear motif (LM) in MKs, the ERK-independent activation of RSK, the RSK-independent effects of some RSK-inhibitors and the challenged role of MK5/PRAK in tumor suppression.
Emergence of plasmid-mediated quinolone-resistant determinants in Klebsiella pneumoniae isolates from Tehran and Qazvin provinces, Iran.
Pahlevan et al., Qazvīn, Iran. In J Prev Med Hyg, 2014
Susceptibility to quinolone compounds were examined by standard Kirby-Bauer disk diffusion method according to the CLSI guideline.
Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway.
GeneRIF
Dong et al., Austin, United States. In J Biol Chem, 2012
Epidermal growth factor (EGF) induces ribosomal S6 kinase 2 (RSK2) ubiquitination, and knocking down TRAF2 suppresses ubiquitination of RSK2 induced by EGF
Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.
GeneRIF
Gross et al., Saint Louis, United States. In J Biol Chem, 2012
transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment.
Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction.
Impact
Barrientos et al., Miami, United States. In Cell Metab, 2012
We have explored the role of mitochondrial function in aging by genetically and pharmacologically modifying yeast cellular respiration production during the exponential and/or stationary growth phases and determining how this affects chronological life span (CLS).
Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.
GeneRIF
Dunn et al., Vancouver, Canada. In Stem Cells, 2012
Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.
Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus.
GeneRIF
Fitzgerald et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia.
Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.
GeneRIF
Su et al., Beijing, China. In Acta Crystallogr D Biol Crystallogr, 2012
structure indicates that activation of RSK1 involves the removal of alpha-helix from the substrate-binding groove induced by ERK1/2 phosphorylation
Genetic basis for in vivo daptomycin resistance in enterococci.
Impact
Weinstock et al., Houston, United States. In N Engl J Med, 2011
Two genes encoded putative enzymes involved in phospholipid metabolism, GdpD (which denotes glycerophosphoryl diester phosphodiesterase) and Cls (which denotes cardiolipin synthetase), and one gene encoded a putative membrane protein, LiaF (which denotes lipid II cycle-interfering antibiotics protein but whose exact function is not known).
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.
Impact
Shadel et al., New Haven, United States. In Cell Metab, 2011
This metabolic alteration increases mitochondrial membrane potential and reactive oxygen species (ROS) production, which we propose supplies an adaptive signal during growth that extends chronological life span (CLS).
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