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Testis-specific serine kinase substrate

clone 4, TSKS
This gene is a member of a small family of testis-specific serine/threonine kinases. This gene may play a role in testicular physiology or spermiogenesis. Its expression is restricted to the testis during the last stages of spermatid maturation. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, POLYMERASE, V1a
Papers using clone 4 antibodies
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses
Supplier
Pardoll Drew M. et al., In The Journal of Experimental Medicine, 2002
... Thy1.1 background HA (clone 4) transgenic mice were the gift ...
Peripheral deletion of autoreactive CD8+ T cells in transgenic mice expressing H-2Kb in the liver
Supplier
Sherman Linda A. et al., In The Journal of Experimental Medicine, 1994
... Clone 4 TCR transgenic mice ...
Switch of CD8 T cells to noncytolytic CD8−CD4−cells that make TH2 cytokines and help B cells
Supplier
Dutton Richard W. et al., In The Journal of Experimental Medicine, 1992
... Clone 4 Vβ8.2/Vα10
Papers on clone 4
Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2.
New
Herr et al., Charlottesville, United States. In Protein Expr Purif, Feb 2016
Development of a selective inhibitor for this kinase first necessitates the production of highly purified, soluble human TSSK2 and its substrate, TSKS, with high yields and retention of biological activity for crystallography and compound screening.
PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.
Varmuza et al., Toronto, Canada. In Reproduction, 2014
Subsequent interaction experiments confirmed the capability of PPP1CC2 to form a complex with TSSK1 mediated by the direct interaction of each with the kinase substrate protein TSKS.
Karyotype variability in tropical maize sister inbred lines and hybrids compared with KYS standard line.
Aguiar-Perecin et al., Piracicaba, Brazil. In Front Plant Sci, 2013
We identified the somatic chromosomes of sister inbred lines that were derived from a tropical flint maize population (Jac Duro [JD]), and hybrids between them, using FISH probes for the 180-bp knob repeat, centromeric satellite (CentC), centromeric satellite 4 (Cent4), subtelomeric clone 4-12-1, 5S ribosomal DNA and nucleolus organizing region DNA sequences.
The attenuated nine mile phase II clone 4/RSA439 strain of Coxiella burnetii is highly virulent for severe combined immunodeficient (SCID) mice.
Graves et al., Australia. In Am J Trop Med Hyg, 2013
The Nine Mile phase II clone 4 (NMIIC4) strain of Coxiella burnetii is an attenuated phase II strain that has lost the genes for virulence determinant type 1 lipopolysaccharide.
Directed evolution of aminoglycoside phosphotransferase (3') type IIIa variants that inactivate amikacin but impose significant fitness costs.
Matsumura et al., Atlanta, United States. In Plos One, 2012
After four rounds of random mutation and selection in Escherichia coli, the minimum inhibitory concentration of amikacin rose from 18 micrograms/mL (wild-type enzyme) to over 1200 micrograms/mL (clone 4.1).
Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6.
Miyazaki et al., Suita, Japan. In Plos One, 2012
We previously isolated a subclone, MIN6 clone 4, from the parental MIN6 cells, that shows well-regulated insulin secretion in response to glucose, glybenclamide, and KCl, even after prolonged culture.
IFN-γ-independent intraocular tumor rejection is mediated by a macrophage-dependent process that leaves the eye intact.
Niederkorn et al., Dallas, United States. In J Leukoc Biol, 2012
By contrast, the second clone of Ad5E1, clone 4, undergoes rejection that also requires T cells and ocular macrophages, but leaves the eye in pristine condition (nonphthisical rejection).
Functional impairment of P-glycoprotein by sodium nitroprusside pretreatment in mouse brain capillary endothelial cells.
Chung et al., South Korea. In Arch Pharm Res, 2012
We examined whether pretreatment of mouse brain blood vessel endothelial cell clone 4 (MBEC4) cells with sodium nitroprusside (SNP), a NO(x) donor, as an in vitro model of the bloodbrain barrier could affect P-glycoprotein (P-gp) functional activity.
Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.
GeneRIF
Grootegoed et al., Rotterdam, Netherlands. In J Cell Sci, 2010
In elongating spermatids, data detected accumulation of the testis-specific TSSK1 and TSSK2, and the substrate TSKS, in a ring-shaped structure around the base of the flagellum and in a cytoplasmic satellite.
Rising atmospheric CO2 concentration partially masks the negative effects of elevated O3 in silver birch (Betula pendula Roth).
Review
Tulva et al., Finland. In Ambio, 2009
In contrast, growth in clone 4 was not enhanced by EC, and EO reduced growth with root growth being most affected.
Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.
Review
Herr et al., Charlottesville, United States. In Soc Reprod Fertil Suppl, 2006
A family of testis specific serine/threonine kinases, TSSK1-4 and SSTK, in addition to the substrate of TSSK1 & 2, TSKS, have been studied during the past several years in our laboratory.
Systemic lupus erythematosus and human endogenous retroviruses.
Hashimoto et al., Shizuoka, Japan. In Mod Rheumatol, 2003
Here we review and discuss the possible role of HERV, especially HERV clone 4-1, in the onset of SLE, based on recent findings including our own data.
Therapy of cancer metastasis by activation of the inducible nitric oxide synthase.
Review
Fidler et al., Houston, United States. In Cancer Metastasis Rev, 1998
Direct evidence for the role of iNOS in metastasis has been provided by our data on transfection of highly metastatic murine K-1735 clone 4 (C4.P) cells which express low levels of iNOS, with a functional iNOS (C4.L8), inactive mutated iNOS (C4.S2), or neomycin resistance (C4.Neo) genes in medium containing 3 mM of the specific iNOS inhibitor NG-L-methyl arginine (NMA).
Activation of nitric oxide synthase gene for inhibition of cancer metastasis.
Review
Fidler et al., Houston, United States. In J Leukoc Biol, 1996
To provide direct evidence for the inverse correlation between the production of endogenous NO and the ability of K-1735 cells to produce metastasis in syngeneic mice, highly metastatic clone 4 cells (C4.P), which express low levels of iNOS, were transfected with a functional iNOS (C4.L8), inactive mutated iNOS (C4.S2), or neomycin resistance (C4.Neo) genes in medium containing 3 mM NMA. C4.P, C4.Neo3, and C4.S2.3 cells were highly metastatic, whereas C4.L8.5 cells were not.
[Retroviral infection as a putative pathogen for sarcoidosis].
Review
Kira et al., In Nihon Rinsho, 1994
Expression of clone 4-1 env protein, one of the endogenous retroviral elements, was also observed in alveolar macrophages of sarcoidosis.
Nonallelic members of the cytochrome c multigene family of the rat may arise through different messenger RNAs.
Impact
Wu et al., In Cell, 1983
In contrast with a fourth gene (from Ch4A-RC4), which has an intron and correctly encodes rat cytochrome c, these three appear to be pseudogenes and resemble mRNA molecules in two respects: they are all missing the intron of clone 4, and sequence homology with clone 4 in their 3' noncoding regions abruptly ends at two different A-rich tracts reminiscent of poly(A) tails.
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