MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
Philadelphia, United States. In Cell Metab, Jan 2016
The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor.
Circadian molecular clock in lung pathophysiology.
Rochester, United States. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
At the molecular level these circadian rhythms depend on the activity of an autoregulatory feedback loop oscillator of clock gene transcription factors, including the BMAL1:CLOCK activator complex and the repressors PERIOD and CRYPTOCHROME.
Circadian Dysfunction Induces Leptin Resistance in Mice.
Houston, United States. In Cell Metab, Oct 2015
Per and Cry mutant mice show similar disruption of peripheral clock and deregulation of leptin in fat, but opposite body weight and composition phenotypes that correlate with their distinct patterns of POMC neuron deregulation in the arcuate nucleus.
Molecular components of the circadian clock in mammals.
Dallas, United States. In Diabetes Obes Metab, Sep 2015
The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH-PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to activate the transcription of the Period and Cryptochrome genes, which in turn feed back to repress their own transcription.
[Circadian markers and genes in bipolar disorder].
Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
Update of sleep alterations in depression.
Mexico. In Sleep Sci, 2014
Among the mechanisms of sleep disturbances in depression are hyperactivation of the hypothalamic-pituitary-adrenal axis, CLOCK gene polymorphism and primary sleep disorders.