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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Circadian locomotor output cycles kaput

This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tic, CRY1, period 2, CAN, CCA1
Papers on CLOCK
Xu et al., Suzhou, China. In Arch Insect Biochem Physiol, Feb 2016
A 37°C, 30-min high-temperature stimulation induced transcription of the circadian clock genes Cry1, Cry2, Per, and Tim.
Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.
Xu et al., Nanjing, China. In Cell Rep, Feb 2016
UNASSIGNED: In the core mammalian circadian negative feedback loop, the BMAL1-CLOCK complex activates the transcription of the genes Period (Per) and Cryptochrome (Cry).
Toward a Valid Animal Model of Bipolar Disorder: How the Research Domain Criteria Help Bridge the Clinical-Basic Science Divide.
Suppes et al., Palo Alto, United States. In Biol Psychiatry, Feb 2016
Further, translating the biology of bipolar disorder in humans into animal models has led to greater understanding of roles for candidate biological systems such as the GRIK2 and CLOCK genes, as well as the extracellular signal-related kinase pathway involved in the pathophysiology of the illness.
Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis.
Athey et al., Ann Arbor, United States. In Neurogastroenterol Motil, Jan 2016
This review focuses on the rapidly developing observations that cortisol is responsible for driving circadian and ultradian bursts of transcriptional activity in the CLOCK (clock circadian regulator) and PER (period circadian clock 1) gene families, and this rhythm is disrupted in major depressive disorder, bipolar disorder, and stress-related gastrointestinal and immune disorders.
Chronic mild stress-induced alterations of clock gene expression in rat prefrontal cortex: Modulatory effects of prolonged lurasidone treatment.
Riva et al., Milano, Italy. In Pharmacol Res, Jan 2016
UNASSIGNED: Disruptions of biological rhythms are known to be associated with depressive disorders, suggesting that abnormalities in the molecular clock may contribute to the development of these disorders.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
Dang et al., Philadelphia, United States. In Cell Metab, Jan 2016
The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor.
Circadian Clock Genes Modulate Human Bone Marrow Mesenchymal Stem Cell Differentiation, Migration and Cell Cycle.
Larghero et al., Paris, France. In Plos One, Dec 2015
Many of the components that regulate the circadian clock have been identified in organisms and humans.
Circadian molecular clock in lung pathophysiology.
Rahman et al., Rochester, United States. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
At the molecular level these circadian rhythms depend on the activity of an autoregulatory feedback loop oscillator of clock gene transcription factors, including the BMAL1:CLOCK activator complex and the repressors PERIOD and CRYPTOCHROME.
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
Bass et al., Chicago, United States. In Science, Dec 2015
The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior and metabolism with the solar cycle.
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.
Asher et al., Israel. In Cell Metab, Dec 2015
In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1.
Circadian Dysfunction Induces Leptin Resistance in Mice.
Fu et al., Houston, United States. In Cell Metab, Oct 2015
Per and Cry mutant mice show similar disruption of peripheral clock and deregulation of leptin in fat, but opposite body weight and composition phenotypes that correlate with their distinct patterns of POMC neuron deregulation in the arcuate nucleus.
Molecular components of the circadian clock in mammals.
Takahashi, Dallas, United States. In Diabetes Obes Metab, Sep 2015
The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH-PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to activate the transcription of the Period and Cryptochrome genes, which in turn feed back to repress their own transcription.
[Circadian markers and genes in bipolar disorder].
Belliviera et al., Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
Update of sleep alterations in depression.
Moctezuma et al., Mexico. In Sleep Sci, 2014
Among the mechanisms of sleep disturbances in depression are hyperactivation of the hypothalamic-pituitary-adrenal axis, CLOCK gene polymorphism and primary sleep disorders.
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.
Sassone-Corsi et al., Irvine, United States. In Cell, 2014
Specifically, the NAD(+)-dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to clock function.
Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally.
Schibler et al., Genève, Switzerland. In Science, 2012
CIRP confers robustness to circadian oscillators through regulation of CLOCK expression.
A mutation in CLOCK leads to altered dopamine receptor function.
McClung et al., Dallas, United States. In J Neurochem, 2012
The results of this study showed that loss of function of the circadian transcription factor CLOCK results in robust changes in dopaminergic transmission and dopamine receptor function.
REV-ERBα and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge.
Takumi et al., Italy. In J Biol Regul Homeost Agents, 2012
REV-ERBalpha may participate in the entrainment of central and peripheral clocks, functioning as a synchronizing hinge of the clock gene machinery.
Clock gene expression in mouse kidney and testis: analysis of periodical and dynamical patterns.
Cai et al., San Giovanni Rotondo, Italy. In J Biol Regul Homeost Agents, 2012
in the testis the clock gene machinery shows a tissue-specific pattern of function and clock genes may play a different role in the testis with regard to other peripheral tissues.
Neuronal influence on peripheral circadian oscillators in pupal Drosophila prothoracic glands.
Ikeda et al., Toyama, Japan. In Nat Commun, 2011
In prothoracic gland cells associated with the CNS, however, per transcription is markedly amplified following 12-h light exposure, resulting in the manifestation of day-night rhythms in nuclear PER immunostaining levels and spontaneous Ca2+ spiking.
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