MRI signatures of the frontotemporal lobar degeneration continuum.
In Hum Brain Mapp, 28 Apr 2015
METHODS: T1-weighted and DT MRI were collected from 121 subjects: 35 motor neuron disease (MND), 14 behavioral variant of frontotemporal dementia, 12 semantic and 11 nonfluent primary progressive aphasia, 21 progressive supranuclear palsy syndrome patients, and 28 healthy controls.
Unwinding the role of senataxin in neurodegeneration.
San Diego, United States. In Discov Med, Feb 2015
Senataxin also joins a group of important proteins responsible for maintaining RNA transcriptome homeostasis, including FUS, TDP-43, and SMN that can all cause familial forms of motor neuron disease (MND).
Advances in motor neurone disease.
Oxford, United Kingdom. In J R Soc Med, 2014
Motor neurone disease (MND), the commonest clinical presentation of which is amyotrophic lateral sclerosis (ALS), is regarded as the most devastating of adult-onset neurodegenerative disorders.
The neuropathology of sport.
Boston, United States. In Acta Neuropathol, 2014
CTE often occurs as a sole diagnosis, but may be associated with other neurodegenerative disorders, including motor neuron disease (CTE-MND).
RNA dysregulation in diseases of motor neurons.
Philadelphia, United States. In Annu Rev Pathol, 2011
In children, inherited spinal muscular atrophies are the predominant diseases that affect motor neurons, whereas in adults, amyotrophic lateral sclerosis, which is inherited but mostly sporadic, is the most common MND.