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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calmegin

CLN, Calmegin, Clgn
Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CLN2, CLN3, CAN, ACID
Papers on CLN
Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease.
New
Martini et al., Würzburg, Germany. In Glia, Feb 2016
UNASSIGNED: CLN diseases are mostly fatal lysosomal storage diseases that lead to neurodegeneration in the CNS.
The Presence of Sterols Favors Sticholysin I-Membrane Association and Pore Formation Regardless of Their Ability to Form Laterally Segregated Domains.
New
Alvarez et al., Havana, Cuba. In Langmuir, Oct 2015
To gain insight into the role of membrane properties on the functional activity of St I, we studied its binding to monolayers and vesicles of phosphatidylcholine (PC), sphingomyelin (SM), and sterols inducing (ergosterol -Erg and cholesterol -Chol) or not (cholestenone - Cln) membrane phase segregation in liquid ordered (Lo) and liquid disordered (Ld) domains.
Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model.
New
de Paiva et al., King of Prussia, United States. In Invest Ophthalmol Vis Sci, Sep 2015
Dendritic cell activation was measured in draining cervical lymph nodes (CLN) by flow cytometry.
Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness.
New
Yoon et al., Suwŏn, South Korea. In J Biol Chem, Sep 2015
We have reported previously that human hepatoma cells harboring mitochondrial defects have high tumor cell invasion activity via increased claudin-1 (Cln-1) expression.
Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study.
New
Impact
Shustov et al., Budapest, Hungary. In J Clin Oncol, Sep 2015
PURPOSE: Peripheral T-cell lymphomas (PTCLs) represent a diverse group of non-Hodgkin lymphomas with a poor prognosis and no accepted standard of care for patients with relapsed or refractory disease.
Jacaric acid inhibits the growth of murine macrophage-like leukemia PU5-1.8 cells by inducing cell cycle arrest and apoptosis.
Leung et al., Hong Kong, Hong Kong. In Cancer Cell Int, 2014
BACKGROUND: Conjugated linolenic acids (CLN) refer to the positional and geometric isomers of octadecatrienoic acids with three conjugated double bonds (C18:3).
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.
Impact
Loog et al., Tartu, Estonia. In Nature, 2012
In Saccharomyces cerevisiae, the initiation of S phase is thought to be governed by complexes of Cdk1 and Cln cyclins that phosphorylate six or more sites on the Clb5-Cdk1 inhibitor Sic1, directing it to SCF-mediated destruction.
Dairy constituents and neurocognitive health in ageing.
Review
Stough et al., Australia. In Br J Nutr, 2011
A literature search of current (September 2010) meta-analyses/reviews and original research regarding dairy products and cognition was conducted through SCOPUS using the following search terms for dairy consituents: dairy, milk, cheese, yoghurt, probiotics, whey protein, alpha lactalbumin, calcium, B-12, bioactive peptides and colostrinin (CLN).
Mechanisms of fertilization--a view from the study of gene-manipulated mice.
Review
Okabe et al., Suita, Japan. In J Androl, 2011
Unexpectedly, sperm from 5 different gene-disrupted mouse lines (calmegin (Clgn), Adam1a, Adam2, Adam3, and Ace) all have defective zona-binding ability and oviduct-migrating ability.
The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion.
Review
Okabe et al., Suita, Japan. In Asian J Androl, 2011
However, this is not likely, as there are already six different gene-disrupted mouse lines (Calmegin, Adam1a, Adam2, Adam3, Ace and Pgap1), all of which result in male sterility.
Cancer chemopreventive ability of conjugated linolenic acids.
Review
Miyashita et al., Gifu, Japan. In Int J Mol Sci, 2010
In contrast to other types of CFAs including CLA that are found at low concentrations (less than 1%) in natural products, conjugated linolenic acids (CLN) are the only CFAs that occur in higher quantities in natural products.
A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway.
Impact
Pryciak et al., Worcester, United States. In Cell, 2007
As cells commit to a new cycle, G1 CDK activity (Cln/CDK) inhibits signaling through the mating MAPK cascade.
Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase.
GeneRIF
Kwon et al., Seoul, South Korea. In Exp Mol Med, 2005
calmegin expression is regulated by histone deacetylase and CpG methyltransferase in a coordinative way
Selective passage through the uterotubal junction of sperm from a mixed population produced by chimeras of calmegin-knockout and wild-type male mice.
GeneRIF
Okabe et al., Ōsaka, Japan. In Biol Reprod, 2004
Calmegin-knockout sperm, even when they were combined in chimeric ejaculates with wild-type sperm, remained outside of the uterotubal junction.
Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5.
Impact
Wittenberg et al., Los Angeles, United States. In Cell, 2004
Cln/CDK phosphorylation of Whi5 in vitro promotes its dissociation from SBF complexes.
Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane.
GeneRIF
Okabe et al., Suita, Japan. In Dev Biol, 2002
The sperm defect in calmegin-null animals is not at the level of sperm-EPM binding but rather may involve either sperm-ZP binding and/or sperm transit to the oviduct.
Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating.
Impact
Peter et al., Switzerland. In Nat Cell Biol, 2000
At bud emergence, activation of the G1 cyclin-dependent kinase Cdc28-Cln triggers degradation of Far1 and, as a result, relocation of Cdc24 to the cytoplasm.
Progressive myoclonus epilepsy: Unverricht-Lundborg disease and Neuronal ceroid lipofuscinoses
Review
Gardiner et al., Bethesda, United States. In Unknown Journal, 0001
Unverricht-Lundborg disease (ULD; EPM1) and the neuronal ceroid lipofuscinoses (NCL; CLN) are clinically and genetically heterogeneous inherited neurodegenerative disorders characterized by myoclonus, epilepsy and progressive neurologic deterioration of varying degree.
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