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CDC-like kinase 4

CLK4
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p58, CDC2, Clk, CLK3, DYRK1A
Papers on CLK4
Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.
Becker et al., Aachen, Germany. In Plos One, 2014
An optimized inhibitor, AnnH75, inhibited CLK1, CLK4, and haspin/GSG2 as the only off-targets in a panel of 300 protein kinases.
Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease.
Review
Trivedi et al., Bhopāl, India. In Curr Drug Targets, 2014
The CLK family consists of four isoforms namely CLK1, CLK2, CLK3 and CLK4.
Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts.
Potterat et al., Basel, Switzerland. In Planta Med, 2012
While the flavonoids and emodin did not show significant differences in the potency of their activities, harmine (1) was most active against DYRK1A, CLK1, and CLK4, and less potent against the other kinases, with selectivity ranging from 2- to 20-fold.
Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.
GeneRIF
Hagiwara et al., Kyoto, Japan. In J Cell Biol, 2011
Clk1/4 expression induced by stress-responsive splicing serves to maintain the phosphorylation state of SR proteins.
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.
Knapp et al., Oxford, United Kingdom. In Chem Biol, 2011
Here, we report the discovery and characterization of the dichloroindolyl enaminonitrile KH-CB19, a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
GeneRIF
Rauch et al., Berlin, Germany. In Circ Res, 2009
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress.
Yoshida et al., Tokyo, Japan. In Oncogene, 2009
Here, we identify CLK1, CLK4, MST1, MST2 and TTK (also known as Mps1) as novel Thr735 kinases in vitro by expression cloning strategy using phosphospecific antibody.
Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair.
Klein et al., New York City, United States. In Mutat Res, 2007
RT-PCR results paralleled the Affymetrix results for four selected genes (HMOX1, DDIT4, GCLM, and CLK4).
Protein kinase clk/STY is differentially regulated during erythroleukemia cell differentiation: a bias toward the skipped splice variant characterizes postcommitment stages.
Krimer et al., Madrid, Spain. In Cell Res, 2005
clk2, clk3 and clk4), are up-regulated during HMBA-induced erythroleukemia cell differentiation.
Structural analysis of UBL5, a novel ubiquitin-like modifier.
Reilly et al., United States. In Protein Sci, 2003
In addition, we have confirmed an earlier report of an interaction between UBL5 and the cyclin-like kinase, CLK4, which we have determined is specific and does not extend to other cyclin-like kinase family members.
Beacon interacts with cdc2/cdc28-like kinases.
Collier et al., Australia. In Biochem Biophys Res Commun, 2003
CLK4, an isoform of cdc2/cdc28-like kinase family of proteins, was identified as a strong interacting partner for beacon.
Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35 [correction of 4q35].
Wallasch et al., Martinsried, Germany. In Genomics, 2001
Employing nucleotide sequence comparison of human expressed sequence tag sequences to the murine counterpart, we identified, cloned, and recombinantly expressed the human orthologue to the murine CLK4 cDNA.
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