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CDC-like kinase 3

CLK3, dual specificity protein kinase CLK3, phclk3
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Clk, CDC2, DYRK1A, CLK2, p58
Papers on CLK3
Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members.
New
Ketteler et al., London, United Kingdom. In Biochemistry, Feb 2016
We identified structural elements within the benzobisthiazole that determine CLK2 and CLK3 inhibition, thus providing a rationale for selectivity assays.
Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease.
Review
Trivedi et al., Bhopāl, India. In Curr Drug Targets, 2014
The CLK family consists of four isoforms namely CLK1, CLK2, CLK3 and CLK4.
Predicting kinase activity in angiotensin receptor phosphoproteomes based on sequence-motifs and interactions.
Christensen et al., Glostrup, Denmark. In Plos One, 2013
Of these, Aurora B, CLK3 and PKG1 have not previously been described in the pathway whereas others, such as PKA, PKB and PKC, are well known.
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.
Iwao et al., Nagasaki, Japan. In J Med Chem, 2013
The kinase inhibitory activities of both enantiomers were evaluated on eight protein kinases relevant to cancer and neurodegenerative diseases (CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, GSK-3α/β, PIM1, DYRK1A, CLK3, and CK1).
Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases.
Bazureau et al., Rennes, France. In Eur J Med Chem, 2012
These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3α/β, DYRK1A, CLK1 and CLK3).
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Meijer et al., France. In J Med Chem, 2012
Leucettines were cocrystallized with DYRK1A, DYRK2, CLK3, PIM1, and GSK-3β.
Knockdown of HBV surface antigen gene expression by a lentiviral microRNA-based system inhibits HBV replication and HCC growth.
Mengchao et al., Shanghai, China. In J Viral Hepat, 2011
Microarray analysis of tumour-related genes in LVshHBS-transduced HepG2.2.15 cells showed that the expressions of genes involved in cell cycle, differentiation and oncogenesis such as ACP2, BHLHB2, CLK3, CTSC, FOS, NR1D1, PIM1 and SEPT6 genes were downregulated, while that of the E2F3 gene was upregulated.
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.
Knapp et al., Oxford, United Kingdom. In Chem Biol, 2011
Cocrystal structures of KH-CB19 with CLK1 and CLK3 revealed a non-ATP mimetic binding mode, conformational changes in helix αC and the phosphate binding loop and halogen bonding to the kinase hinge region.
[Expression of cell cycle molecules in human azoospermic testes].
GeneRIF
Kang et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2009
regulated but the expression of CDK9, CDC20 and CLK3 was down- regulated in azoospermic testes.
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
GeneRIF
Rauch et al., Berlin, Germany. In Circ Res, 2009
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Knapp et al., Oxford, United Kingdom. In Structure, 2009
To understand functional differences between splicing factor targeting kinases, we determined crystal structures of CLK1 and CLK3.
Gene expression in rat lungs during early response to paraquat-induced oxidative stress.
Ishikawa et al., Kurashiki, Japan. In Int J Mol Med, 2006
Five genes related to oxidative stress, TRX, HO-1, GST-Yc, NQO-1, and RL/IF-1, and one gene, CLK3, whose function is unknown, showed a significant increase in their expression due to PQ injection.
Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism.
Shao et al., China. In Asian J Androl, 2005
Among them, eight up-regulated genes might be cell cycle-related, namely CDC10, NRAS, BTG1, Wee1, CLK3, DKFZP564A122, CDKN1A and BTG2.
Protein kinase clk/STY is differentially regulated during erythroleukemia cell differentiation: a bias toward the skipped splice variant characterizes postcommitment stages.
Krimer et al., Madrid, Spain. In Cell Res, 2005
clk2, clk3 and clk4), are up-regulated during HMBA-induced erythroleukemia cell differentiation.
Specificity determinants of substrate recognition by the protein kinase DYRK1A.
Becker et al., Aachen, Germany. In J Biol Chem, 2000
Exchange of threonine 45 for alanine abolished phosphorylation of histone H3 by DYRK1A and by the related kinases DYRK1B, DYRK2, and DYRK3 but not by CLK3.
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