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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

CDC-like kinase 1

Clk, Sty, CLK1, ST6GalNAc III
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] (from NCBI)
Papers using Clk antibodies
Automated recordings of bioluminescence with special reference to the analysis of circadian rhythms
Supplier
Stemple Derek, In PLoS Biology, 1999
... Madison, Wisconsin, United States), before western blotting (BioRad, Hercules, California, United States) using an anti-mouse CLK (Santa Cruz Biotechnology, Santa Cruz, California, United ...
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing
Supplier
Spector David L. et al., In The Journal of Cell Biology, 1987
... PCR was used to generate restriction sites at the start codon of murine Clk/STY1 and Clk/STY1 (K190R) cDNAs for convenient subcloning into pEGFP-C3 (CLONTECH Laboratories, Inc.) ...
Papers on Clk
Reversal of slow growth and heartbeat through the restoration of mitochondrial function in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.
GeneRIF
Shirasawa et al., Tokyo, Japan. In Exp Gerontol, 2012
The results indicate that clk-1 regulates growth and heart rates through CoQ-mediated mitochondrial functions in mouse embryos.
Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.
GeneRIF
Hagiwara et al., Kyoto, Japan. In J Cell Biol, 2011
Clk1/4 expression induced by stress-responsive splicing serves to maintain the phosphorylation state of SR proteins.
Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy.
GeneRIF
Cochrane et al., Toronto, Canada. In Retrovirology, 2010
CLK1 Increases While CLK2 Decreases HIV-1 Gene Expression.
The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins.
GeneRIF
Lippard et al., Cambridge, United States. In Biochemistry, 2010
Analyses of the in vitro activity of MCLK1 with quinone substrates revealed that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
GeneRIF
Rauch et al., Berlin, Germany. In Circ Res, 2009
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
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