Robenidine analogues as Gram positive antibacterial agents.
In J Med Chem, Feb 2016
μM. 1 and 75 displayed excellent microsomal stability, intrinsic clearance and hepatic extraction ratios with T1/2 > 247 min, CLint <7 μL/min/mg protein and EH <0.22 in both human and mouse liposomes for 1, and human liposomes with 75.
Arylacetamide Deacetylase Is Responsible for Activation of Prasugrel in Human and Dog.
Kanazawa, Japan. In Drug Metab Dispos, Jan 2016
Recombinant human AADAC was shown to catalyze prasugrel hydrolysis with a CLint value of 50.0 ± 1.2 mL/min/mg protein with a similar Km value to human intestinal and liver microsomes, whereas the CLint values of human CES1 and CES2 were 4.6 ± 0.1 mL/min/mg protein and 6.6 ± 0.3 mL/min/mg protein, respectively.
Family-based association study of Epsin 4 and Schizophrenia.
Shanghai, China. In Mol Psychiatry, 2006
Results indicate the presence of a locus near the 5' end of Epsin 4 conferring susceptibility to the disease and provide further support for Epsin 4 as an important potential contributor to genetic risk in schizophrenia.
Peptide motifs: building the clathrin machinery.
Montréal, Canada. In Mol Neurobiol, 2005
Additionally, we identified several new components of the machineries for clathrin-mediated membrane budding, including enthoprotin/epsinR and NECAP 1/2.