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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Clathrin interactor 1

CLint, epsinR, enthoprotin
This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: CAN, CYP3A4, V1a, Cyp, HAD
Papers on CLint
Robenidine analogues as Gram positive antibacterial agents.
New
Trott et al., In J Med Chem, Feb 2016
μM. 1 and 75 displayed excellent microsomal stability, intrinsic clearance and hepatic extraction ratios with T1/2 > 247 min, CLint <7 μL/min/mg protein and EH <0.22 in both human and mouse liposomes for 1, and human liposomes with 75.
Stereoselective Degradation of alpha-Cypermethrin and Its Enantiomers in Rat Liver Microsomes.
New
Zhu et al., Beijing, China. In Chirality, Jan 2016
In rac-α-CP, the Vmax and CLint of (+)-(1R-cis-αS)-CP (5105.22 ± 326.26
Arylacetamide Deacetylase Is Responsible for Activation of Prasugrel in Human and Dog.
New
Nakajima et al., Kanazawa, Japan. In Drug Metab Dispos, Jan 2016
Recombinant human AADAC was shown to catalyze prasugrel hydrolysis with a CLint value of 50.0 ± 1.2 mL/min/mg protein with a similar Km value to human intestinal and liver microsomes, whereas the CLint values of human CES1 and CES2 were 4.6 ± 0.1 mL/min/mg protein and 6.6 ± 0.3 mL/min/mg protein, respectively.
The Nonspecific Binding of Tyrosine Kinase Inhibitors to Human Liver Microsomes.
New
Miners et al., Adelaide, Australia. In Drug Metab Dispos, Dec 2015
Correction for nonspecific binding (NSB) is essential for the accurate calculation of the kinetic parameters Km, Clint, and Ki.
Assessment of in vitro metabolic stability, plasma protein binding, and pharmacokinetics of E- and Z-guggulsterone in rat.
New
Bhatta et al., Lucknow, India. In Drug Test Anal, Dec 2015
In vitro intrinsic clearance (CLint ) was found to be 33.34 ± 0.51 and 39.23 ± 8.12 μL/min/mg protein in rat liver microsomes for E- and Z-isomers, respectively.
Metabolic profiling of a novel antithrombotic compounds, S002-333 and enantiomers: metabolic stability, species comparison and in-vitro in-vivo extrapolation.
New
Gayen et al., Lucknow, India. In Biopharm Drug Dispos, Nov 2015
Prediction of surrogate species and in-vitro in-vivo extrapolation were performed based upon calculated in-vitro intrinsic clearance (CLint ).
Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs.
New
Impact
Martín-Belmonte et al., Madrid, Spain. In Nat Cell Biol, Mar 2015
The protein PLLP (Pllp in fish) recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis.
Practical approaches to resolving reactive metabolite liabilities in early discovery.
Review
New
Chen et al., San Diego, United States. In Drug Metab Rev, Feb 2015
Computation of dose using in vitro intrinsic clearance (Clint), potency data (Ceff) and the fractional contribution of RM pathway (frm), can provide an initial read of the daily burden of RM.
Pharmacokinetic changes of drugs in a rat model of liver cirrhosis induced by dimethylnitrosamine, alone and in combination with diabetes mellitus induced by streptozotocin.
Review
Oh et al., Seoul, South Korea. In Biopharm Drug Dispos, 2015
This review mainly explains the changes in the CLNRs of drugs (which are mainly metabolized via hepatic microsomal cytochrome P450s, CYPs) in LC and LCD rats, in terms of the changes in in vitro hepatic intrinsic clearance (CLint; mainly due to the changes in CYPs in the disease state), free (unbound) fraction of a drug in the plasma (fp) and hepatic blood flow rate (QH) depending on the hepatic excretion ratio of the drug.
Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation.
Terelius et al., Huddinge, Sweden. In Plos One, 2014
The apparent Km for CYP2B6.1 was almost constant (3-4 mM), while the CLint values were proportional to the POR/CYP ratio (3-34 μL/min/nmol CYP).
The Identification of Two Head Smut Resistance-Related QTL in Maize by the Joint Approach of Linkage Mapping and Association Analysis.
Li et al., Beijing, China. In Plos One, 2014
Head smut, caused by the fungus Sphacelotheca reiliana (Kühn) Clint, is a devastating threat to maize production.
Association study of the GRIA1 and CLINT1 (Epsin 4) genes in a German schizophrenia sample.
GeneRIF
Jamra et al., In Psychiatr Genet, 2011
These results do not support a significant role of GRIA1 or CLINT1 in the development of schizophrenia in the German population.
The epsin 4 gene is associated with psychotic disorders in families of Latin American origin.
GeneRIF
Dassori et al., San Antonio, United States. In Schizophr Res, 2008
Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population
Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population.
GeneRIF
Kunugi et al., Kodaira, Japan. In J Neural Transm, 2008
Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese.
A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles.
Impact
GeneRIF
Owen et al., Cambridge, United Kingdom. In Nature, 2007
characterization of the molecular details governing the sorting of a SNARE into clathrin-coated vesicles, namely the direct recognition of the three-helical bundle H(abc) domain of the mouse SNARE Vti1b by the human clathrin adaptor epsinR
Family-based association study of Epsin 4 and Schizophrenia.
GeneRIF
He et al., Shanghai, China. In Mol Psychiatry, 2006
Results indicate the presence of a locus near the 5' end of Epsin 4 conferring susceptibility to the disease and provide further support for Epsin 4 as an important potential contributor to genetic risk in schizophrenia.
Peptide motifs: building the clathrin machinery.
Review
Ritter et al., Montréal, Canada. In Mol Neurobiol, 2005
Additionally, we identified several new components of the machineries for clathrin-mediated membrane budding, including enthoprotin/epsinR and NECAP 1/2.
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.
Review
Sugiyama et al., Tokyo, Japan. In Pharmacol Ther, 1996
Successful predictions were obtained for verapamil, loxtidine (lavoltidine), diazepam, lidocaine, phenacetin and some other compounds where CLint,in vitro is comparable with CLint,in vivo.
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