How many lives does CLIMP-63 have?
Lausanne, Switzerland. In Biochem Soc Trans, Apr 2015
In 1995, in the Biochemical Society Transactions, Mundy published the first review on CLIMP-63 (cytoskeleton-linking membrane protein 63) or CKPA4 (cytoskeleton-associated protein 4), initially just p63 .
Multipronged quantitative proteomic analyses indicate modulation of various signal transduction pathways in human meningiomas.
Mumbai, India. In Proteomics, 2015
Quite a few candidates, such as protein S-100A6, aldehyde dehydrogenase mitochondrial, AHNAK, cytoskeleton-associated protein 4, and caveolin, showed sequential increase in low- and high-grade MGs, whereas differential expressions of collagen alpha-1 (VI), protein S100-A9, 14 kDa phosphohistidine phosphatase, or transgelin-2 were found to be grade specific.
Rab18 and a Rab18 GEF complex are required for normal ER structure.
Suita, Japan. In J Cell Biol, 2014
Supporting the view that Rab18 activity is important for ER structure, in the absence of either Rab3GAP subunit or Rab18 function, ER tubular networks marked by reticulon 4 were disrupted, and ER sheets defined by CLIMP-63 spread out into the cell periphery.
Intracellular mechanisms of aminoglycoside-induced cytotoxicity.
Portland, United States. In Integr Biol (camb), 2011
In this review, we discuss intracellular binding targets of aminoglycosides, highlighting specific aminoglycoside-binding proteins (HSP73, calreticulin and CLIMP-63) and their potential for triggering caspases and Bcl-2 signalling cascades that are involved in aminoglycoside-induced cytotoxicity.
ER sheets get roughed up.
United States. In Cell, 2010
(2010) now report that sheet-inducing proteins, such as Climp-63, are enriched in the "rough" ER by their association with membrane-bound ribosomes, whereas curvature-inducing proteins localize at highly bent edges of membrane sheets.