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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cytoskeleton-associated protein 4

CLIMP-63, CKAP4, 63 kDa membrane protein, cytoskeleton-associated protein 4, cytoskeleton-associated protein 4.1B
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Top mentioned proteins: p63, CAN, fibrillin-1, SP-A, HAD
Papers on CLIMP-63
Transmembrane domain is crucial to the subcellular localization and function of Myc target 1.
New
Chu et al., Shanghai, China. In J Cell Mol Med, Jan 2016
We further identified CKAP4 interacted with MYCT1 and contributed to the function of MYCT1.
A seven-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes.
New
Chiorazzi et al., United States. In Immunol Res, Dec 2015
Therefore, we selected FMOD, CKAP4, PIK3C2B, LEF1, PFTK1, BCL-2, and GPM6a from a set of genes significantly differentially expressed in microarray analyses that compared CLL cells with normal B lymphocytes and used these to determine whether we could discriminate CLL and MBL cells from B cells of healthy controls.
How many lives does CLIMP-63 have?
Review
New
van der Goot et al., Lausanne, Switzerland. In Biochem Soc Trans, Apr 2015
In 1995, in the Biochemical Society Transactions, Mundy published the first review on CLIMP-63 (cytoskeleton-linking membrane protein 63) or CKPA4 (cytoskeleton-associated protein 4), initially just p63 [1].
Multipronged quantitative proteomic analyses indicate modulation of various signal transduction pathways in human meningiomas.
Srivastava et al., Mumbai, India. In Proteomics, 2015
Quite a few candidates, such as protein S-100A6, aldehyde dehydrogenase mitochondrial, AHNAK, cytoskeleton-associated protein 4, and caveolin, showed sequential increase in low- and high-grade MGs, whereas differential expressions of collagen alpha-1 (VI), protein S100-A9, 14 kDa phosphohistidine phosphatase, or transgelin-2 were found to be grade specific.
Valosin-containing protein-interacting membrane protein (VIMP) links the endoplasmic reticulum with microtubules in concert with cytoskeleton-linking membrane protein (CLIMP)-63.
Tagaya et al., Nagahama, Japan. In J Biol Chem, 2014
Our previous study showed that the 42-kDa ER-residing form of syntaxin 5 (Syn5L) regulates ER structure through the interactions with both CLIMP-63 and MTs.
CKAP4 inhibited growth and metastasis of hepatocellular carcinoma through regulating EGFR signaling.
Wang et al., Shanghai, China. In Tumour Biol, 2014
CKAP4, one kind of type II trans-membrane protein, plays an important role to maintain endoplasmic reticulum structure and inhibits the proliferation of bladder cancer cells by combining its ligand anti-proliferative factor (APF).
Rab18 and a Rab18 GEF complex are required for normal ER structure.
Barr et al., Suita, Japan. In J Cell Biol, 2014
Supporting the view that Rab18 activity is important for ER structure, in the absence of either Rab3GAP subunit or Rab18 function, ER tubular networks marked by reticulon 4 were disrupted, and ER sheets defined by CLIMP-63 spread out into the cell periphery.
Prognostic significance of cytoskeleton-associated membrane protein 4 and its palmitoyl acyltransferase DHHC2 in hepatocellular carcinoma.
Wang et al., Shanghai, China. In Cancer, 2014
BACKGROUND: The functions of cytoskeleton-associated membrane protein 4 (CKAP4), one kind of type II transmembrane protein, are associated with the palmitoyl acyltransferase DHHC2.
Untangling the web: mechanisms underlying ER network formation.
Review
Blackstone et al., Bethesda, United States. In Biochim Biophys Acta, 2013
Flat ER sheets possess a different complement of proteins such as p180, CLIMP-63 and kinectin implicated in shaping, cisternal stacking and cytoskeletal interactions.
Non-genomic STAT5-dependent effects at the endoplasmic reticulum and Golgi apparatus and STAT6-GFP in mitochondria.
Review
Sehgal, Valhalla, United States. In Jakstat, 2013
In cross-immunopanning assays STAT5A and B species associated with ATL3, and the ER-lumen spacer CLIMP63 (also called cytoskeleton-associated protein 4, CKAP4) but not RTN4.
Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection.
Wang et al., Shanghai, China. In Cancer Lett, 2013
The objective of the study was to investigate the clinical significance of CKAP4 in intrahepatic cholangiocellular carcinoma (ICC).
Proteomic analysis of balding and non-balding mesenchyme-derived dermal papilla cells from androgenetic alopecia patients using on-line two-dimensional reversed phase-reversed phase LC-MS/MS.
Baek et al., Taegu, South Korea. In J Proteomics, 2013
Up-regulated proteins belonging to these pathways in the balding DPCs, including argininosuccinate synthase 1 (ASS1), phosphoribosylaminoimidazole carboxylase (PAICS; ADE2), cytoskeleton-associated protein 4 (CKAP4), gelsolin (GSN), Ras GTPase-activating-like protein (IQGAP1), and S-phase kinase-associated protein 1 (SKP1), were confirmed by Western blot analysis.
Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology.
GeneRIF
McGrath et al., London, United Kingdom. In Br J Dermatol, 2012
This study identifies specific changes in skin structural biology and signalling pathways that result from mutant p63 and provides new molecular insight into the AEC syndrome phenotype
Antiproliferative factor regulates connective tissue growth factor (CTGF/CCN2) expression in T24 bladder carcinoma cells.
GeneRIF
Planey et al., Scranton, United States. In Mol Biol Cell, 2012
CCN2 regulation by antiproliferative factor involves CKAP4 nuclear translocation and binding to the CCN2 promoter.
Utility of p63 and high molecular weight cytokeratin in the distinction between urothelial carcinoma with prostatic stromal invasion and urothelial carcinoma with colonisation of prostatic ducts and acini.
GeneRIF
Osunkoya et al., Atlanta, United States. In Pathology, 2012
Tumor markers, p63 and high molecular weight cytokeratin, may be utilised in the distinction between urothelial carcinoma with prostatic stromal invasion and urothelial carcinoma with colonisation of prostatic ducts and acini.
p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.
GeneRIF
Rekhtman et al., Baltimore, United States. In Mod Pathol, 2012
These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.
The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles.
GeneRIF
Candi et al., Roma, Italy. In Biochem Pharmacol, 2011
This study found a consistent expression profile and localization analysis of p63 and GM1 in primary keratinocytes and in human epidermal biopsies.
Intracellular mechanisms of aminoglycoside-induced cytotoxicity.
Review
Steyger et al., Portland, United States. In Integr Biol (camb), 2011
In this review, we discuss intracellular binding targets of aminoglycosides, highlighting specific aminoglycoside-binding proteins (HSP73, calreticulin and CLIMP-63) and their potential for triggering caspases and Bcl-2 signalling cascades that are involved in aminoglycoside-induced cytotoxicity.
ER sheets get roughed up.
Impact
Barlowe, United States. In Cell, 2010
(2010) now report that sheet-inducing proteins, such as Climp-63, are enriched in the "rough" ER by their association with membrane-bound ribosomes, whereas curvature-inducing proteins localize at highly bent edges of membrane sheets.
P63 (CKAP4) as an SP-A receptor: implications for surfactant turnover.
Review
Bates, Philadelphia, United States. In Cell Physiol Biochem, 2009
A newly identified receptor for SP-A, P63/CKAP4, is described in detail, with elucidation of the specific structural features of this 63 kDa, nonglycosylated, highly coiled, transmembrane protein.
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