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Chloride intracellular channel 5

This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Actin, Ezrin, CLIC1, ACID, H1
Papers on CLIC5
Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors.
Carén et al., Göteborg, Sweden. In Epigenetics, Feb 2016
Altered expression in nonsurvivors was found for the genes B3GALT4 and KIAA1949, CLIC5, DLX6-AS, TERT, and PIRT, and strongest correlations were found for TRIM36, KIAA0513, and PIRT.
Molecular identity of cardiac mitochondrial chloride intracellular channel proteins.
Singh et al., Philadelphia, United States. In Mitochondrion, Feb 2016
In this study, we report the presence of unique dimorphic Chloride Intracellular Channel proteins (CLICs) namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart.
Cyclic AMP prevents decrease of phosphorylated ezrin/radixin/moesin and chloride intracellular channel 5 expressions in injured podocytes.
Gu et al., Shanghai, China. In Clin Exp Nephrol, Dec 2015
The aim of the present study was to explore the role of forskolin, an agonist for adenylate cyclase, on ezrin/radixin/moesin (ERM) phosphorylation and chloride intracellular channel 5 (CLIC5) expressions in injured podocytes.
Patients with isolated oligo/hypodontia caused by RUNX2 duplication.
Le Caignec et al., Caen, France. In Am J Med Genet A, Jun 2015
To date, two cousins with a duplication including the entire RUNX2 sequence in addition to MIR586, CLIC5 and the 5' half of SUPT3H have been reported.
Progressive hearing loss and vestibular dysfunction caused by a homozygous nonsense mutation in CLIC5.
Schraders et al., Nijmegen, Netherlands. In Eur J Hum Genet, Feb 2015
Subsequent candidate gene evaluation revealed CLIC5 as an excellent candidate gene.
Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs.
Kontula et al., In J Am Heart Assoc, 2015
Replication analyses of GENRES results provided suggestive evidence for a missense variant (rs3814995) in the NPHS1 (nephrin) gene influencing losartan response, and for 2 variants influencing hydrochlorothiazide response, located within or close to the ALDH1A3 (rs3825926) and CLIC5 (rs321329) genes.
Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A.
Ballermann et al., Edmonton, Canada. In J Cell Sci, 2015
CLIC5A (encoded by CLIC5) is a component of the ezrin-NHERF2-podocalyxin complex in renal glomerular podocyte foot processes.
Co-Expression of Ezrin-CLIC5-Podocalyxin Is Associated with Migration and Invasiveness in Hepatocellular Carcinoma.
Villa-Treviño et al., Oaxaca de Juárez, Mexico. In Plos One, 2014
Recently, it has been observed that chloride intracellular channel 5 (CLIC5) forms a complex with EZR and PODXL and that it is required for podocyte structure and function.
Pathway analysis of genome-wide association study on serum prostate-specific antigen levels.
Jia et al., Nanjing, China. In Gene, 2014
Second, CLIC5 rs3734207 and rs11752816 polymorphisms (regulatory region) to the 2 iron, 2 sulfur cluster binding pathway through regulating expression levels of CLIC5 mRNA.
Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model.
Noda et al., Tokyo, Japan. In Biochim Biophys Acta, 2014
The 10 membrane channel proteins covered in this review are aquaporin 2 (AQP2), cystic fibrosis transmembrane conductance regulator (CFTR), ClC2, short form of ClC3 (sClC3), chloride intracellular channel 1 (CLIC1), chloride intracellular channel 5 (CLIC5), epithelial sodium channel (ENaC), large-conductance calcium-activated potassium channel (Maxi-K), transient receptor potential vanilloid 4 (TRPV4), and voltage-dependent anion channel (VDAC), with particular attention to AQP2.
CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.
Berryman et al., Bethesda, United States. In Cytoskeleton (hoboken), 2014
Chloride intracellular channel 5 protein (CLIC5) was originally isolated from microvilli in complex with actin binding proteins including ezrin, a member of the Ezrin-Radixin-Moesin (ERM) family of membrane-cytoskeletal linkers.
Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: a feasibility study.
Chérel et al., Saint-Herblain, France. In World J Gastroenterol, 2013
According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1; AKAP7; CAPN5; CLIC5; CPE; CREB3L1; NEDD4L; RAB27A), ion transport (AKAP7; ATP2A3; CCL28; CLIC5; F2RL2; NEDD4L; SLC6A8), transcription (AKAP7; CREB3L1; ISX; PABPC1L; TXNIP), signal transduction (CAPN5; F2RL2; RAB27A; TNFRSF11A), cell adhesion (ADAMDEC1; PXDN; SPON1; S100A2), immune response (CCL28; PXDN; TNFRSF11A) and apoptosis (ITM2C; PDCD4; PVT1).
MiR-183 family regulates chloride intracellular channel 5 expression in inner ear hair cells.
Liu et al., Foshan, China. In Toxicol In Vitro, 2013
Although there has been no reported link between chloride intracellular channel 5 (CLIC5) and the miR-183 family to date, we here present evidence that they are co-expressed in the inner ear and have functions that are related to stereocilia.
An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk.
Benz et al., In Breast Cancer Res, 2012
From the Buck-4 and IR-7 signatures, an optimized five-gene (TNFRSF17, CLIC5, HLA-F, CXCL13, XCL2) predictor was generated, referred to as the Integrated Cytokine Score (ICS) based on its functional pathway linkage through interferon-γ and IL-10.
[Artificial selection for cattle based on high-density SNP markers].
Gao et al., Beijing, China. In Yi Chuan, 2012
Finally, we found 47104 OUTLIER SNP loci and 3064 candidate genes, for example, CLIC5, TG, CACNA2D1, and FSHR etc.
Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function.
Tsui et al., Ann Arbor, United States. In Kidney Int, 2010
Study identifies CLIC5 as a new component that is enriched in and necessary for foot process integrity and podocyte function in vivo.
CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity.
Ballermann et al., Edmonton, Canada. In Am J Physiol Renal Physiol, 2010
CLIC5A colocalizes with ezrin and podocalyxin in podocytes and is required for the development/maintenance of the proper glomerular endothelial cell and podocyte architecture.
CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor.
Shull et al., Cincinnati, United States. In Am J Physiol Regul Integr Comp Physiol, 2010
Clic5 mutant mice are resistant to diet-induced obesity.
The CLIC5 (chloride intracellular channel 5) involved in C2C12 myoblasts proliferation and differentiation.
Zhang et al., Beijing, China. In Cell Biol Int, 2010
CLIC5 disrupts proliferation of C2C12 cells and is involved in the differentiation of myoblasts by enhancing the protein expression level of MyHC, myogenin and desmin.
Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin.
Ashley et al., Edinburgh, United Kingdom. In Febs J, 2007
Data showed that CLIC1 and CLIC5, but not CLIC4, were strongly and reversibly inhibited (or inactivated) by F-actin.
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